Yıl: 2023 Cilt: 9 Sayı: 3 Sayfa Aralığı: 201 - 211 Metin Dili: İngilizce DOI: 10.3153/FH23019 İndeks Tarihi: 24-07-2023

Hazelnut-enriched diet effectively increases lipoproteins' resistance to oxidation in hypercholesterolemic subjects

Öz:
Oxidative modifications of lipoproteins are crucial in the early stages of cardiovascular diseases (CVD) like hypercholesterolemia. The major aim is to determine the effects of hazelnut consump- tion on the resistance of low- and high-density lipoproteins to oxidation in hypercholesterolemic subjects. Fifteen hypercholesterolemic subjects (13 men, 2 women) who did not require drug tre- atment according to the National Cholesterol Education Program Adult Treatment Panel III criteria and had serum levels of TC˃200 mg/dL were included in the study. This study was designed as a dual control sandwich model intervention with a single group, isoenergetic three periods. The pe- riods were; Control Diet I (30 days), Hazelnut-Enriched Diet (30 days), and Control Diet II (30 days). The susceptibility of LDL and HDL to copper-mediated oxidation was determined spect- rophotometrically by following conjugated diene formation. The resistance of lipoproteins, mainly LDL, was increased by hazelnut consumption. It can be concluded that a hazelnut-enriched diet had protective effects against lipoprotein oxidation in hypercholesterolemic subjects. These chan- ges may play important roles in reducing the development of the atherosclerotic process.
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  • Akhlaghi, M., Ghobadi, S., Zare, M., Foshati, S. (2020). Effect of nuts on energy intake, hunger, and fullness, a sys- tematic review and meta-analysis of randomized clinical tri- als. Critical Reviews in Food Science and Nutrition, 60(1), 84–93. https://doi.org/10.1080/10408398.2018.1514486
  • Balaban Yucesan, F., Orem, A., Vanizor Kural, B., Orem, C., Turan, I. (2010). Hazelnut consumption decreases the susceptibility of LDL to oxidation, plasma oxidized LDL level and increases the ratio of large/small LDL in normoli- pidemic healthy subjects. Anadolu Kardiyoloji Dergisi/The Anatolian Journal of Cardiology, 10, 28-35. https://doi.org/10.5152/akd.2010.007
  • Borén, J., Chapman, M. J., Krauss, R. M., Packard, C. J., Bentzon, J. F., Binder, C. J., et al. (2020). Low-density lip- oproteins cause atherosclerotic cardiovascular disease: path- ophysiological, genetic, and therapeutic insights: a consensus statement from the European Atherosclerosis Society Con- sensus Panel. European Heart Journal, 41(24), 2313–2330. https://doi.org/10.1093/eurheartj/ehz962
  • Brown, R., Ware, L., Tey, S. L. (2022). Effects of Hazelnut Consumption on Cardiometabolic Risk Factors and Ac- ceptance: A Systematic Review. In International Journal of Environmental Research and Public Health, 19(5), 2880. https://doi.org/10.3390/ijerph19052880
  • Deon, V., del Bo’, C., Guaraldi, F., Abello, F., Belviso, S., Porrini, M., Riso, P., Guardamagna, O. (2018). Effect of hazelnut on serum lipid profile and fatty acid composition of erythrocyte phospholipids in children and adolescents with primary hyperlipidemia: A randomized controlled trial. Clin- ical Nutrition, 37(4), 1193–1201. https://doi.org/10.1016/j.clnu.2017.05.022
  • Durak, I., Koksal, I., Kacmaz, M., Buyukkocak, S., Ci- men, B.M.Y., Ozturk, H.S. (1999). Hazelnut supplementa- tion enhances plasma antioxidant potential and lowers plasma cholesterol levels. Clinica Chimica Acta, 284, 113–115. https://doi.org/10.1016/S0009-8981(99)00066-2
  • Edwards, K., Kwaw, I., Matud, J., Kurtz, I. (1999). Effect of Pistachio Nuts on Serum Lipid Levels in Patients with Moderate Hypercholesterolemia. Journal of the American College of Nutrition, 18(3), 229-232. (https://doi.org/10.1080/07315724.1999.10718856
  • Fraser, G.E. (2000). Nut consumption, lipids, and risk of a coronary event. Asia Pacific Journal of Clinical Nutrition, 111, 11-15. https://doi.org/10.1046/j.1440-6047.2000.00181.x
  • Garner, B., Waldeck, A.R., Witting, P.K., Rye, K.-A., Stocker, R. (1998). Oxidation of high-density lipoproteins. II. Evidence for direct reduction of lipid hydroperoxides by methionine residues of apolipoproteins AI and AII. Journal of Biological Chemistry, 273 (13), 6088-6095. https://doi.org/10.1074/jbc.273.11.6088
  • Gießauf, A., Steiner, E., Esterbauer, H. (1995). Early de- struction of tryptophan residues of apolipoprotein B is a vita- min E-independent process during copper-mediated oxida- tion of LDL. Biochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism, 1256(2), 221–232. https://doi.org/10.1016/0005-2760(95)00024-7
  • Grundy, S.M., Cleeman, J.I., Bairey Merz, C.N., Brewer, H.B., Clark, L. T., Hunninghake, D.B., Pasternak, R.C., Smith, S.C., Stone, N.J. (2004). Implications of recent clin- ical trials for the National Cholesterol Education Program Adult Treatment Panel III guidelines. Circulation,110, 227- 239. https://doi.org/10.1161/01.CIR.0000133317.49796.0E
  • Hargrove, R.L., Etherton, T.D., Pearson, T.A., Harrison, E.H., Kris-Etherton, P.M. (2001). Low fat and high mono- unsaturated fat diets decrease human low density lipoprotein oxidative susceptibility in vitro. The Journal of Nutrition, 131(6), 1758–1763. https://doi.org/10.1093/jn/131.6.1758
  • Hasselwander, O., McEneny, J., McMaster, D., Fogarty, D.G., Nicholls, D.P., Maxwell, A.P., Young, I.S. (1999). HDL composition and HDL antioxidant capacity in patients on regular haemodialysis. Atherosclerosis, 143(1), 125-133. https://doi.org/10.1016/S0021-9150(98)00286-X
  • Jiang, R., Jacobs, D.R., Mayer-Davis, E., Szklo, M., Her- rington, D., Jenny, N.S., Kronmal, R., Barr, R.G. (2006). Nut and seed consumption and inflammatory markers in the Multi-Ethnic Study of Atherosclerosis. American Journal of Epidemiology,163(3), 222-231. https://doi.org/10.1093/aje/kwj033
  • Kocyigit, A., Koylu, A.A., Keles, H. (2006). Effects of pis- tachio nuts consumption on plasma lipid profile and oxidative status in healthy volunteers. Nutrition, Metabolism and Car- diovascular Diseases, 16(3), 202–209. https://doi.org/10.1016/j.numecd.2005.08.004
  • Oliver H., Lowry, Nira J., Rosebrough A., Lewis Farr, Rose Randall (1951). Protein measurement with the folin phenol reagent. Journal of Biological Chemistry. 193(1), 265-275. https://doi.org/10.1021/jf1005935.
  • MercanlIgil, S.M., Arslan, P., Alasalvar, C., Okut, E., Akgül, E., PInar, A., Geyik, P.Ö., Tokgözoǧlu, L., Sha- hidi, F. (2007). Effects of hazelnut-enriched diet on plasma cholesterol and lipoprotein profiles in hypercholesterolemic adult men. European Journal of Clinical Nutrition. 61, 212- 220. https://doi.org/10.1038/sj.ejcn.1602518
  • Mukuddem-Petersen, J., Oosthuizen, W., Jerling, J. C. (2005). A systematic review of the effects of nuts on blood lipid profiles in humans. The Journal of Nutrition, 135(9), 2082–2089. https://doi.org/10.1093/jn/135.9.2082
  • Nag, T., Ghosh, A. (2013). Cardiovascular disease risk fac- tors in Asian Indian population: A systematic review. Journal of Cardiovascular Disease Research, 4(4), 222-228. https://doi.org/10.1016/j.jcdr.2014.01.004
  • Negre-Salvayre, A., Dousset, N., Ferretti, G., Bacchetti, T., Curatola, G., Salvayre, R. (2006). Antioxidant and cy- toprotective properties of high-density lipoproteins in vascu- lar cells. Free Radical Biology and Medicine, 41(7), 1031- 1040. https://doi.org/10.1016/j.freeradbiomed.2006.07.006
  • Nicholls, S.J., Nelson, A. J. (2019). HDL and cardiovascular disease. Pathology, 51(2), 142–147. https://doi.org/10.1016/j.pathol.2018.10.017
  • Norata, G.D., Pirillo, A., Catapano, A.L. (2006). Modified HDL: Biological and physiopathological consequences. Nu- trition, Metabolism and Cardiovascular Diseases, 16(5), 371-386. https://doi.org/10.1016/j.numecd.2006.01.012
  • Öngün Yilmaz, H., Özyildirim, B. (2019). Evaluation of the effects of raisins and hazelnuts added to the diet on lipid pro- files and anthropometric measurements in women with hy- perlipidemia. Bezmialem Science, 7(4), 294–306. https://doi.org/10.14235/bas.galenos.2019.2969
  • Orem, A., Yucesan, F. B., Orem, C., Akcan, B., Kural, B. V., Alasalvar, C., Shahidi, F. (2013). Hazelnut-enriched diet improves cardiovascular risk biomarkers beyond a lipid-low- ering effect in hypercholesterolemic subjects. Journal of Clinical Lipidology, 7(2), 123-131. https://doi.org/10.1016/j.jacl.2012.10.005
  • Proudfoot, J. M., Croft, K. D., Puddey, I. B., Beilin, L. J. (1997). The role of copper reduction by α-tocopherol in low- density lipoprotein oxidation. Free Radical Biology and Med- icine, 23(5), 720-728. https://doi.org/10.1016/S0891-5849(97)00015-4
  • Puhl, H., Waeg, G., Esterbauer, H. (1994). Methods to de- termine oxidation of low-density lipoproteins. Methods in Enzymology, 233, 425-441. https://doi.org/10.1016/S0076-6879(94)33049-2
  • Renzo, L. Di, Cioccoloni, G., Bernardini, S., Abenavoli, L., Aiello, V., Marchetti, M., Cammarano, A., Alipour- fard, I., Ceravolo, I., Gratteri, S. (2019). A hazelnut-en- riched diet modulates oxidative stress and inflammation gene expression without weight gain. Oxidative Medicine and Cel- lular Longevity, 2019, 1-11 https://doi.org/10.1155/2019/4683723
  • Ros, E., Nunez, I., Perez-Heras, A., Serra, M., Gilabert, R., Casals, E., Deulofeu, R. (2004). A walnut diet improves endothelial function in hypercholesterolemic subjects: A ran- domized crossover trial. Circulation, 109(13), 1609-1614. https://doi.org/10.1161/01.CIR.0000124477.91474.FF
APA AKCAN B, Orem A, VANİZOR KURAL B, altinkaynak y, BALABAN YUCESAN F, örem C (2023). Hazelnut-enriched diet effectively increases lipoproteins' resistance to oxidation in hypercholesterolemic subjects. , 201 - 211. 10.3153/FH23019
Chicago AKCAN Buket,Orem Asım,VANİZOR KURAL Birgül,altinkaynak yahya,BALABAN YUCESAN Fulya,örem Cihan Hazelnut-enriched diet effectively increases lipoproteins' resistance to oxidation in hypercholesterolemic subjects. (2023): 201 - 211. 10.3153/FH23019
MLA AKCAN Buket,Orem Asım,VANİZOR KURAL Birgül,altinkaynak yahya,BALABAN YUCESAN Fulya,örem Cihan Hazelnut-enriched diet effectively increases lipoproteins' resistance to oxidation in hypercholesterolemic subjects. , 2023, ss.201 - 211. 10.3153/FH23019
AMA AKCAN B,Orem A,VANİZOR KURAL B,altinkaynak y,BALABAN YUCESAN F,örem C Hazelnut-enriched diet effectively increases lipoproteins' resistance to oxidation in hypercholesterolemic subjects. . 2023; 201 - 211. 10.3153/FH23019
Vancouver AKCAN B,Orem A,VANİZOR KURAL B,altinkaynak y,BALABAN YUCESAN F,örem C Hazelnut-enriched diet effectively increases lipoproteins' resistance to oxidation in hypercholesterolemic subjects. . 2023; 201 - 211. 10.3153/FH23019
IEEE AKCAN B,Orem A,VANİZOR KURAL B,altinkaynak y,BALABAN YUCESAN F,örem C "Hazelnut-enriched diet effectively increases lipoproteins' resistance to oxidation in hypercholesterolemic subjects." , ss.201 - 211, 2023. 10.3153/FH23019
ISNAD AKCAN, Buket vd. "Hazelnut-enriched diet effectively increases lipoproteins' resistance to oxidation in hypercholesterolemic subjects". (2023), 201-211. https://doi.org/10.3153/FH23019
APA AKCAN B, Orem A, VANİZOR KURAL B, altinkaynak y, BALABAN YUCESAN F, örem C (2023). Hazelnut-enriched diet effectively increases lipoproteins' resistance to oxidation in hypercholesterolemic subjects. Food and Health, 9(3), 201 - 211. 10.3153/FH23019
Chicago AKCAN Buket,Orem Asım,VANİZOR KURAL Birgül,altinkaynak yahya,BALABAN YUCESAN Fulya,örem Cihan Hazelnut-enriched diet effectively increases lipoproteins' resistance to oxidation in hypercholesterolemic subjects. Food and Health 9, no.3 (2023): 201 - 211. 10.3153/FH23019
MLA AKCAN Buket,Orem Asım,VANİZOR KURAL Birgül,altinkaynak yahya,BALABAN YUCESAN Fulya,örem Cihan Hazelnut-enriched diet effectively increases lipoproteins' resistance to oxidation in hypercholesterolemic subjects. Food and Health, vol.9, no.3, 2023, ss.201 - 211. 10.3153/FH23019
AMA AKCAN B,Orem A,VANİZOR KURAL B,altinkaynak y,BALABAN YUCESAN F,örem C Hazelnut-enriched diet effectively increases lipoproteins' resistance to oxidation in hypercholesterolemic subjects. Food and Health. 2023; 9(3): 201 - 211. 10.3153/FH23019
Vancouver AKCAN B,Orem A,VANİZOR KURAL B,altinkaynak y,BALABAN YUCESAN F,örem C Hazelnut-enriched diet effectively increases lipoproteins' resistance to oxidation in hypercholesterolemic subjects. Food and Health. 2023; 9(3): 201 - 211. 10.3153/FH23019
IEEE AKCAN B,Orem A,VANİZOR KURAL B,altinkaynak y,BALABAN YUCESAN F,örem C "Hazelnut-enriched diet effectively increases lipoproteins' resistance to oxidation in hypercholesterolemic subjects." Food and Health, 9, ss.201 - 211, 2023. 10.3153/FH23019
ISNAD AKCAN, Buket vd. "Hazelnut-enriched diet effectively increases lipoproteins' resistance to oxidation in hypercholesterolemic subjects". Food and Health 9/3 (2023), 201-211. https://doi.org/10.3153/FH23019