The Effects of Coenzyme Q10 (CoQ10) on Ionizing  Radiation- Induced Pancreatic β-Cell Injury

Mercantepe, Filiz; Tumkaya, Levent; mercantepe, tolga; Yılmaz Rakıcı, Sema

The Effects of Coenzyme Q10 (CoQ10) on Ionizing Radiation- Induced Pancreatic β-Cell Injury

Filiz MERCANTEPE, (Recep Tayyip Erdoğan Üniversitesi, Tıp Fakültesi, Endokrinoloji Anabilim Dalı ve Metabolizma Hastalığı, Rize, Türkiye)

Levent TÜMKAYA, (Recep Tayyip Erdoğan Üniversitesi, Tıp Fakültesi, Histoloji ve Embriyoloji Anabilim Dalı, Rize, Türkiye)

Tolga MERCANTEPE, (Recep Tayyip Erdoğan Üniversitesi, Tıp Fakültesi, Histoloji ve Embriyoloji Anabilim Dalı, Rize, Türkiye)

Sema RAKICI (Resepsiyon Tayyip Erdoğan Üniversitesi, Tıp Fakültesi, Radyasyon Onkolojisi Anabilim Dalı, Rize, Türkiye)

Endocrinology research and practice

1 0

Yıl: 2023 Cilt: 27 Sayı: 3 Sayfa Aralığı: 125 - 134 Metin Dili: İngilizce İndeks Tarihi: 25-07-2023

The Effects of Coenzyme Q10 (CoQ10) on Ionizing Radiation- Induced Pancreatic β-Cell Injury

Öz:

Objective: This study investigated the antioxidant effect of coenzyme Q10 on ionizing radiation induced oxidative damage in pancreatic β-cells. Methods: Twenty-four male rats were assigned to 4 groups. Group 1 constituted the control group, Group 2 only received a single i.p. dose of coenzyme Q10, Groups 3 and 4 received a total of 4 Gy external x-ray radiation to the abdomen in a single fraction. Group 4 also received a single dose of 200 mg/kg coenzyme Q10 i.p. 30 minutes prior to x-ray irradiation. Results: The x-ray radiation group showed decreased β-cell positivity in the islets of Langerhans com pared to the control group on immunohistochemical analysis. In contrast, an increase in β-cells exhib iting insulin positivity was observed in group 4 (ionizing radiation+coenzyme Q10) compared to the irradiation group. Terminal deoxynucleotidyl transferase dUTP nick end labeling assay indicated a rise in the number of apoptotic cells in the x-ray radiation group compared to the control and coenzyme Q10-only groups (Group 2). Meanwhile, we observed a decrease in the number of terminal deoxy nucleotidyl transferase dUTP nick end labeling-positive apoptotic cells in the islets of Langerhans in the ionizing radiation+coenzyme Q10 treatment group (Group 4) relative to the irradiation group. Conclusion: This study shows that coenzyme Q10 reduces apoptosis in the rat pancreas exposed to abdominal ionizing radiation.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Mercantepe F, Tumkaya L, mercantepe t, Yılmaz Rakıcı S (2023). The Effects of Coenzyme Q10 (CoQ10) on Ionizing Radiation- Induced Pancreatic β-Cell Injury. , 125 - 134.
Chicago	Mercantepe Filiz,Tumkaya Levent,mercantepe tolga,Yılmaz Rakıcı Sema The Effects of Coenzyme Q10 (CoQ10) on Ionizing Radiation- Induced Pancreatic β-Cell Injury. (2023): 125 - 134.
MLA	Mercantepe Filiz,Tumkaya Levent,mercantepe tolga,Yılmaz Rakıcı Sema The Effects of Coenzyme Q10 (CoQ10) on Ionizing Radiation- Induced Pancreatic β-Cell Injury. , 2023, ss.125 - 134.
AMA	Mercantepe F,Tumkaya L,mercantepe t,Yılmaz Rakıcı S The Effects of Coenzyme Q10 (CoQ10) on Ionizing Radiation- Induced Pancreatic β-Cell Injury. . 2023; 125 - 134.
Vancouver	Mercantepe F,Tumkaya L,mercantepe t,Yılmaz Rakıcı S The Effects of Coenzyme Q10 (CoQ10) on Ionizing Radiation- Induced Pancreatic β-Cell Injury. . 2023; 125 - 134.
IEEE	Mercantepe F,Tumkaya L,mercantepe t,Yılmaz Rakıcı S "The Effects of Coenzyme Q10 (CoQ10) on Ionizing Radiation- Induced Pancreatic β-Cell Injury." , ss.125 - 134, 2023.
ISNAD	Mercantepe, Filiz vd. "The Effects of Coenzyme Q10 (CoQ10) on Ionizing Radiation- Induced Pancreatic β-Cell Injury". (2023), 125-134.

APA	Mercantepe F, Tumkaya L, mercantepe t, Yılmaz Rakıcı S (2023). The Effects of Coenzyme Q10 (CoQ10) on Ionizing Radiation- Induced Pancreatic β-Cell Injury. Endocrinology research and practice, 27(3), 125 - 134.
Chicago	Mercantepe Filiz,Tumkaya Levent,mercantepe tolga,Yılmaz Rakıcı Sema The Effects of Coenzyme Q10 (CoQ10) on Ionizing Radiation- Induced Pancreatic β-Cell Injury. Endocrinology research and practice 27, no.3 (2023): 125 - 134.
MLA	Mercantepe Filiz,Tumkaya Levent,mercantepe tolga,Yılmaz Rakıcı Sema The Effects of Coenzyme Q10 (CoQ10) on Ionizing Radiation- Induced Pancreatic β-Cell Injury. Endocrinology research and practice, vol.27, no.3, 2023, ss.125 - 134.
AMA	Mercantepe F,Tumkaya L,mercantepe t,Yılmaz Rakıcı S The Effects of Coenzyme Q10 (CoQ10) on Ionizing Radiation- Induced Pancreatic β-Cell Injury. Endocrinology research and practice. 2023; 27(3): 125 - 134.
Vancouver	Mercantepe F,Tumkaya L,mercantepe t,Yılmaz Rakıcı S The Effects of Coenzyme Q10 (CoQ10) on Ionizing Radiation- Induced Pancreatic β-Cell Injury. Endocrinology research and practice. 2023; 27(3): 125 - 134.
IEEE	Mercantepe F,Tumkaya L,mercantepe t,Yılmaz Rakıcı S "The Effects of Coenzyme Q10 (CoQ10) on Ionizing Radiation- Induced Pancreatic β-Cell Injury." Endocrinology research and practice, 27, ss.125 - 134, 2023.
ISNAD	Mercantepe, Filiz vd. "The Effects of Coenzyme Q10 (CoQ10) on Ionizing Radiation- Induced Pancreatic β-Cell Injury". Endocrinology research and practice 27/3 (2023), 125-134.