TY  - JOUR
TI  - Leukocyte Telomere Length and Its Association  with Serum Silent Information Regulator-1, Body  Composition, Glycemic Control, and Diabetic  Complications in Type 2 Diabetes Mellitus
AB  - Objective: The aim of this study is to investigate the length of telomere and serum silent information  regulator-1 levels in type 2 diabetic subjects as well as their associations with body composition,  glycemic control, and diabetic complications. Methods: We enrolled 84 type 2 diabetic subjects and 40 controls. The length of telomere and serum  silent information regulator-1 (Sirtuin-1) levels, body composition and diabetic complications were  examined. Results: Median T/S ratio tended to be lower in type 2 diabetic subjects compared to the controls  (1.03 (0.20-1.48) vs. 1.25 (0.80-1.69), P=.064); however, the percentage of having shorter telomere  (T/S ratio < 1) was significantly higher in type 2 diabetic subjects than in the controls (47.6% vs.  27.5%, P=.035). Serum Sirtuin-1 level was lower in type 2 diabetic subjects than in controls (95.48 ± 29.9 vs. 138.40 ± 42.66 pg/mL, P < .001). There were no differences in the length of telomere and  serum sirtuin-1 between the groups divided according to the presence of diabetic complications  (P > .05). The percentage of having shorter telomere was higher in obese patients than in non-obese  patients with DM (35.7% vs. 60%, P=.029). The T/S ratio was correlated with truncal fat in type 2  diabetic subjects (r=−0.250, P=.028). Conclusions: The length of telomere and silent information regulator-1 may have a role in cellular  aging in type 2 diabetic subjects in relation to visceral obesity.
AU  - ÜNVER, NAZMİ GÖKHAN
AU  - EROĞLU ALTINOVA, ALEV
AU  - Coşkun, Meriç
AU  - AKTURK, MUJDE
AU  - yalcin, mehmet muhittin
AU  - Törüner, Füsun
AU  - YETKİN, İLHAN
DO  - 10.5152/erp.2023.22199
PY  - 2023
JO  - Endocrinology research and practice
VL  - 27
IS  - 3
SN  - 2822-6135
SP  - 148
EP  - 153
DB  - TRDizin
UR  - http://search/yayin/detay/1189508
ER  -