Are follistatin-like protein 1 and follistatin-like protein 3 associated with inflammatory processes in patients with familial Mediterranean fever?

CALIS, Mustafa; SENEL, ABDURRAHMAN SONER; KAPLAN, HÜSEYİN; YAZICI, Cevat; Güntürk, İnayet; Cüce, İsa

doi:10.14744/nci.2022.54189

Are follistatin-like protein 1 and follistatin-like protein 3 associated with inflammatory processes in patients with familial Mediterranean fever?

Hüseyin KAPLAN, (Erciyes Üniversitesi, Tıp Fakültesi, Fiziksel Tıp ve Rehabilitasyon Anabilim Dalı, Romatoloji Anabilim Dalı, Kayseri, Türkiye)

Mustafa CALIS, (Erciyes Üniversitesi, Tıp Fakültesi, Fiziksel Tıp ve Rehabilitasyon Anabilim Dalı, Kayseri, Türkiye)

CEVAT YAZICI, (Erciyes Üniversitesi, Tıp Fakültesi, Fiziksel Tıp ve Rehabilitasyon Anabilim Dalı, Kayseri, Türkiye)

İnayet GÜNTÜRK, (Niğde Ömer Halisdemir Üniversitesi, Sağlık Bilimleri Fakültesi, Ebelik Bölümü, Niğde, Türkiye)

İsa CÜCE, (Erciyes Üniversitesi, Tıp Fakültesi, Fiziksel Tıp ve Rehabilitasyon Anabilim Dalı, Kayseri, Türkiye)

ABDURRAHMAN SONER SENEL (Erciyes Üniversitesi, Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Romatoloji Anabilim Dalı, Kayseri, Türkiye)

İstanbul Kuzey Klinikleri

0 0

Yıl: 2023 Cilt: 10 Sayı: 3 Sayfa Aralığı: 306 - 313 Metin Dili: İngilizce DOI: 10.14744/nci.2022.54189 İndeks Tarihi: 27-07-2023

Are follistatin-like protein 1 and follistatin-like protein 3 associated with inflammatory processes in patients with familial Mediterranean fever?

Öz:

OBJECTIVE: Follistatin-like protein 1 (FSTL-1) and follistatin-like protein 3 (FSTL-3) are glycoproteins whose associations with inflammatory cytokines were reported in previous studies. However, it is not yet known whether they have an effect on the pathogenesis of familial Mediterranean fever (FMF). We aimed to detect the FSTL-1 and FSTL-3 levels and to determine their relationship to the attack status and mutation types in patients with FMF. METHODS: Fifty-six FMF patients and 22 healthy controls (HCs) were included in the study. Serum FSTL-1 and FSTL-3 levels were measured with the enzyme-linked immunosorbent assay method from collected serum samples. In addition, the MEditerranean FeVer (MEFV) gene mutation types of the patients were noted. RESULTS: Serum FSTL-1 levels were significantly higher in FMF patients than in HCs (p=0.005). However, there was no significant difference in FSTL-1 levels between patients in the attack period (n=26) and in the attack-free period (n=30). FSTL-3 levels were similar between FMF patients and HCs or patients in the attack period and in the attack-free period. Furthermore, the MEFV mutation type and attack status had no significant effect on FSTL-1 and FSTL-3 levels (p>0.05). CONCLUSION: Our results suggest that FSTL-1 may be associated with the pathogenesis of FMF, rather than FSTL-3. However, neither serum FSTL-1 nor FSTL-3 seems to be good markers to reflect inflammatory activity.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

1. Onen F. Familial mediterranean fever. Rheumatol Int 2006;26:489–96.
2. Dogan H, Akdemir F, Tasdemir S, Atis O, Diyarbakir E, Yildirim R, et al. A novel insertion mutation identified in exon 10 of the MEFV gene associated with Familial Mediterranean Fever. BMC Med Genet 2014;15:74.
3. Jarjour RA, Dodaki R. Arthritis patterns in familial Mediterranean fever patients and association with M694V mutation. Mol Biol Rep 2011;38:2033–36.
4. Petrushkin H, Stanford M, Fortune F, Jawad AS. Clinical review: familial mediterranean fever—an overview of pathogenesis, symptoms, ocular manifestations, and treatment. Ocul Immunol Inflamm 2016;24:422–30.
5. Karadeniz H, Güler AA, Atas N, Satış H, Salman RB, Babaoglu H, et al. Tofacitinib for the treatment for colchicine-resistant familial Mediterranean fever: case-based review. Rheumatol Int 2020;40:169–73.
6. Alghamdi M. Familial Mediterranean fever, review of the literature. Clin Rheumatol 2017;36:1707–13.
7. Omenetti A, Carta S, Delfino L, Martini A, Gattorno M, Rubartelli A. Increased NLRP3-dependent interleukin 1β secretion in patients with familial Mediterranean fever: correlation with MEFV genotype. Ann Rheum Dis 2014;73:462–69.
8. Tufan A, Lachmann H. Familial Mediterranean fever, from pathogenesis to treatment: a contemporary review. Turk J Med Sci 2020;50:1591– 610.
9. Mattiotti A, Prakash S, Barnett P, van den Hoff MJ. Follistatin-like 1 in development and human diseases. Cell Mol Life Sci 2018;75:2339–54.
10. Clutter SD, Wilson DC, Marinov AD, Hirsch R. Follistatin-like protein 1 promotes arthritis by up-regulating IFN-γ. J Immunol 2009;182:234–39.
11. Wilson DC, Marinov AD, Blair HC, Bushnell DS, Thompson SD, Chaly Y, et al. Follistatin-like protein 1 is a mesenchyme-derived inflammatory protein and may represent a biomarker for systemic-onset juvenile rheumatoid arthritis. Arthritis Rheum 2010;62:2510–16.
12. Chaly Y, Fu Y, Marinov A, Hostager B, Yan W, Campfield B, et al. Follistatin-like protein 1 enhances NLRP3 inflammasome-mediated IL-1β secretion from monocytes and macrophages. Eur J Immunol 2014;44:1467–79.
13. Brandt C, Pedersen M, Rinnov A, Andreasen AS, Møller K, Hojman P, et al. Obesity and low-grade inflammation increase plasma follistatin- like 3 in humans. Mediators Inflamm 2014;2014:364209.
14. Liu G, Chen S, Deng S, Ma X, Hao Y, Bu G. Association of follistatin- like 3 concentrations in serum and synovial fluid with the radiographic severity of knee osteoarthritis. Int J Clin Exp Med 2015;8:18884–88.
15. Sarı İ, Birlik M, Kasifoğlu T. Familial Mediterranean fever: an updated review. Eur J Rheumatol 2014;1:21–33.
16. Tanaka M, Ozaki S, Osakada F, Mori K, Okubo M, Nakao K. Cloning of follistatin-related protein as a novel autoantigen in systemic rheumatic diseases. Int Immunol 1998;10:1305–14.
17. Chaly Y, Hostager B, Smith S, Hirsch R. Follistatin-like protein 1 and its role in inflammation and inflammatory diseases. Immunol Res 2014;59:266–72.
18. Li D, Wang Y, Xu N, Wei Q, Wu M, Li X, et al. Follistatin-like protein 1 is elevated in systemic autoimmune diseases and correlated with disease activity in patients with rheumatoid arthritis. Arthritis Res Ther 2011;13:R17.
19. Koga T, Migita K, Sato S, Umeda M, Nonaka F, Kawashiri SY, et al. Multiple serum cytokine profiling to identify combinational diagnostic biomarkers in attacks of familial Mediterranean fever. Medicine (Baltimore) 2016;95:e3449.
20. Bozkurt Y, Demir A, Erman B, Gül A. Unified modeling of familial Mediterranean fever and cryopyrin associated periodic syndromes. Comput Math Methods Med 2015;2015:893507.
21. de Torre-Minguela C, Mesa del Castillo P, Pelegrín P. The NLRP3 and pyrin inflammasomes: Implications in the pathophysiology of autoinflammatory diseases. Front Immunol 2017;8:43.
22. Hoffman HM. Rilonacept for the treatment of cryopyrin-associated periodic syndromes (CAPS). Expert Opin Biol Ther 2009;9:519–31.
23. Miyamae T. Cryopyrin-associated periodic syndromes. Paediatr Drugs 2012;14:109–17.
24. Gorelik M, Bushnell D, Goldbach-Mansky RT, Hoffman HM, Hirsch R. Elevated serum follistatin-like protein 1 suggests an interleukin-1 independent pathway for inflammation in patients with cryopyrin associated periodic syndromes. Arthritis Rheum 2012;64:S1125–6.
25. Varan O, Kucuk H, Babaoglu H, Tecer D, Atas N, Bilici Salman R, et al. Chronic inflammation in adult familial Mediterranean fever patients: underlying causes and association with amyloidosis. Scand J Rheumatol 2019;48:315–19.
26. Wei Y, Wang S, Wang D, Liu C. Expression and clinical significance of serum amyloid A and interleukin 6 in patients with acute exacerbation of chronic obstructive pulmonary disease. Exp Ther Med 2020;19:2089–94.
27. Ben-Zvi I, Livneh A. Chronic inflammation in FMF: markers, risk factors, outcomes and therapy. Nat Rev Rheumatol 2011;7:105–12.
28. Çakan M, Karadağ Ş, Tanatar A, Sönmez HE, Ayaz NA. The value of serum amyloid A levels in familial Mediterranean fever to identify occult inflammation during asymptomatic periods. J Clin Rheumatol 2021;27:1–4.
29. Mukhin NA, Kozlovskaya LV, Bogdanova MV, Rameev VV, Moiseev SV, Simonyan AK. Predictors of AA amyloidosis in familial Mediterranean fever. Rheumatol Int 2015;35:1257–61.
30. Ebrahimi-Fakhari D, Schönland S, Hegenbart U, Lohse P, Beimler J, Wahlster L, et al. Familial Mediterranean fever in Germany: clinical presentation and amyloidosis risk. Scand J Rheumatol 2013;42:52–8.
31. Grossman C, Kassel Y, Livneh A, Ben-Zvi I. Familial Mediterranean fever (FMF) phenotype in patients homozygous to the MEFV M694V mutation. Eur J Med Genet 2019;62:103532.

APA	KAPLAN H, CALIS M, YAZICI C, Güntürk İ, Cüce İ, SENEL A (2023). Are follistatin-like protein 1 and follistatin-like protein 3 associated with inflammatory processes in patients with familial Mediterranean fever?. , 306 - 313. 10.14744/nci.2022.54189
Chicago	KAPLAN HÜSEYİN,CALIS Mustafa,YAZICI Cevat,Güntürk İnayet,Cüce İsa,SENEL ABDURRAHMAN SONER Are follistatin-like protein 1 and follistatin-like protein 3 associated with inflammatory processes in patients with familial Mediterranean fever?. (2023): 306 - 313. 10.14744/nci.2022.54189
MLA	KAPLAN HÜSEYİN,CALIS Mustafa,YAZICI Cevat,Güntürk İnayet,Cüce İsa,SENEL ABDURRAHMAN SONER Are follistatin-like protein 1 and follistatin-like protein 3 associated with inflammatory processes in patients with familial Mediterranean fever?. , 2023, ss.306 - 313. 10.14744/nci.2022.54189
AMA	KAPLAN H,CALIS M,YAZICI C,Güntürk İ,Cüce İ,SENEL A Are follistatin-like protein 1 and follistatin-like protein 3 associated with inflammatory processes in patients with familial Mediterranean fever?. . 2023; 306 - 313. 10.14744/nci.2022.54189
Vancouver	KAPLAN H,CALIS M,YAZICI C,Güntürk İ,Cüce İ,SENEL A Are follistatin-like protein 1 and follistatin-like protein 3 associated with inflammatory processes in patients with familial Mediterranean fever?. . 2023; 306 - 313. 10.14744/nci.2022.54189
IEEE	KAPLAN H,CALIS M,YAZICI C,Güntürk İ,Cüce İ,SENEL A "Are follistatin-like protein 1 and follistatin-like protein 3 associated with inflammatory processes in patients with familial Mediterranean fever?." , ss.306 - 313, 2023. 10.14744/nci.2022.54189
ISNAD	KAPLAN, HÜSEYİN vd. "Are follistatin-like protein 1 and follistatin-like protein 3 associated with inflammatory processes in patients with familial Mediterranean fever?". (2023), 306-313. https://doi.org/10.14744/nci.2022.54189

APA	KAPLAN H, CALIS M, YAZICI C, Güntürk İ, Cüce İ, SENEL A (2023). Are follistatin-like protein 1 and follistatin-like protein 3 associated with inflammatory processes in patients with familial Mediterranean fever?. İstanbul Kuzey Klinikleri, 10(3), 306 - 313. 10.14744/nci.2022.54189
Chicago	KAPLAN HÜSEYİN,CALIS Mustafa,YAZICI Cevat,Güntürk İnayet,Cüce İsa,SENEL ABDURRAHMAN SONER Are follistatin-like protein 1 and follistatin-like protein 3 associated with inflammatory processes in patients with familial Mediterranean fever?. İstanbul Kuzey Klinikleri 10, no.3 (2023): 306 - 313. 10.14744/nci.2022.54189
MLA	KAPLAN HÜSEYİN,CALIS Mustafa,YAZICI Cevat,Güntürk İnayet,Cüce İsa,SENEL ABDURRAHMAN SONER Are follistatin-like protein 1 and follistatin-like protein 3 associated with inflammatory processes in patients with familial Mediterranean fever?. İstanbul Kuzey Klinikleri, vol.10, no.3, 2023, ss.306 - 313. 10.14744/nci.2022.54189
AMA	KAPLAN H,CALIS M,YAZICI C,Güntürk İ,Cüce İ,SENEL A Are follistatin-like protein 1 and follistatin-like protein 3 associated with inflammatory processes in patients with familial Mediterranean fever?. İstanbul Kuzey Klinikleri. 2023; 10(3): 306 - 313. 10.14744/nci.2022.54189
Vancouver	KAPLAN H,CALIS M,YAZICI C,Güntürk İ,Cüce İ,SENEL A Are follistatin-like protein 1 and follistatin-like protein 3 associated with inflammatory processes in patients with familial Mediterranean fever?. İstanbul Kuzey Klinikleri. 2023; 10(3): 306 - 313. 10.14744/nci.2022.54189
IEEE	KAPLAN H,CALIS M,YAZICI C,Güntürk İ,Cüce İ,SENEL A "Are follistatin-like protein 1 and follistatin-like protein 3 associated with inflammatory processes in patients with familial Mediterranean fever?." İstanbul Kuzey Klinikleri, 10, ss.306 - 313, 2023. 10.14744/nci.2022.54189
ISNAD	KAPLAN, HÜSEYİN vd. "Are follistatin-like protein 1 and follistatin-like protein 3 associated with inflammatory processes in patients with familial Mediterranean fever?". İstanbul Kuzey Klinikleri 10/3 (2023), 306-313. https://doi.org/10.14744/nci.2022.54189