Mannose-binding lectin (MBL) levels in children with Hashimoto’s thyroiditis
Yıl: 2023 Cilt: 10 Sayı: 3 Sayfa Aralığı: 353 - 358 Metin Dili: İngilizce DOI: 10.14744/nci.2022.22058 İndeks Tarihi: 27-07-2023
Mannose-binding lectin (MBL) levels in children with Hashimoto’s thyroiditis
Öz: OBJECTIVE: Hashimoto’s thyroiditis (HT) was described many years ago, but the etiopathogenesis remains unclear. Mannose- binding lectin (MBL) initiates complement activation in the lectin pathway. We determined MBL levels in children with HT and the associations thereof with thyroid hormone and thyroid autoantibody levels. METHODS: Thirty-nine patients with HT and 41 controls were enrolled from the pediatric outpatient clinics. Subjects were grouped according to their thyroid functions: Euthyroid, marked hypothyroidism and clinical/subclinical hyperthyroidism. MBL levels were compared among these groups. Serum MBL levels of the subjects were determined using MBL Human ELISA kit. RESULTS: Serum MBL levels were studied in serum samples from the 80 subjects (48 (60.0%) females). MBL levels in HT and control groups were 50.787±34.718 and 50.593±44.28 ng/ml (p=0,983), respectively. In HT group, there was no significant difference in MBL levels between thyroid function groups (p=0.869). In addition, gender was not detected as a factor for serum MBL levels. Also we found negative correlation between WBC and serum MBL levels (r=-0.532; p=0.050). Otherwise there was no correlation between TSH, anti-TPO and anti-TG with serum MBL levels. CONCLUSION: MBL levels did not decrease in HT patients. Further research is needed to elucidate more fully any role for MBL in the development of autoimmune thyroid disease.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | Gul A, Hatipoglu N, YILMAZ R, ATES H (2023). Mannose-binding lectin (MBL) levels in children with Hashimoto’s thyroiditis. , 353 - 358. 10.14744/nci.2022.22058 |
| Chicago | Gul Ali,Hatipoglu Nihal,YILMAZ RESUL,ATES HACI OMER Mannose-binding lectin (MBL) levels in children with Hashimoto’s thyroiditis. (2023): 353 - 358. 10.14744/nci.2022.22058 |
| MLA | Gul Ali,Hatipoglu Nihal,YILMAZ RESUL,ATES HACI OMER Mannose-binding lectin (MBL) levels in children with Hashimoto’s thyroiditis. , 2023, ss.353 - 358. 10.14744/nci.2022.22058 |
| AMA | Gul A,Hatipoglu N,YILMAZ R,ATES H Mannose-binding lectin (MBL) levels in children with Hashimoto’s thyroiditis. . 2023; 353 - 358. 10.14744/nci.2022.22058 |
| Vancouver | Gul A,Hatipoglu N,YILMAZ R,ATES H Mannose-binding lectin (MBL) levels in children with Hashimoto’s thyroiditis. . 2023; 353 - 358. 10.14744/nci.2022.22058 |
| IEEE | Gul A,Hatipoglu N,YILMAZ R,ATES H "Mannose-binding lectin (MBL) levels in children with Hashimoto’s thyroiditis." , ss.353 - 358, 2023. 10.14744/nci.2022.22058 |
| ISNAD | Gul, Ali vd. "Mannose-binding lectin (MBL) levels in children with Hashimoto’s thyroiditis". (2023), 353-358. https://doi.org/10.14744/nci.2022.22058 |
| APA | Gul A, Hatipoglu N, YILMAZ R, ATES H (2023). Mannose-binding lectin (MBL) levels in children with Hashimoto’s thyroiditis. İstanbul Kuzey Klinikleri, 10(3), 353 - 358. 10.14744/nci.2022.22058 |
| Chicago | Gul Ali,Hatipoglu Nihal,YILMAZ RESUL,ATES HACI OMER Mannose-binding lectin (MBL) levels in children with Hashimoto’s thyroiditis. İstanbul Kuzey Klinikleri 10, no.3 (2023): 353 - 358. 10.14744/nci.2022.22058 |
| MLA | Gul Ali,Hatipoglu Nihal,YILMAZ RESUL,ATES HACI OMER Mannose-binding lectin (MBL) levels in children with Hashimoto’s thyroiditis. İstanbul Kuzey Klinikleri, vol.10, no.3, 2023, ss.353 - 358. 10.14744/nci.2022.22058 |
| AMA | Gul A,Hatipoglu N,YILMAZ R,ATES H Mannose-binding lectin (MBL) levels in children with Hashimoto’s thyroiditis. İstanbul Kuzey Klinikleri. 2023; 10(3): 353 - 358. 10.14744/nci.2022.22058 |
| Vancouver | Gul A,Hatipoglu N,YILMAZ R,ATES H Mannose-binding lectin (MBL) levels in children with Hashimoto’s thyroiditis. İstanbul Kuzey Klinikleri. 2023; 10(3): 353 - 358. 10.14744/nci.2022.22058 |
| IEEE | Gul A,Hatipoglu N,YILMAZ R,ATES H "Mannose-binding lectin (MBL) levels in children with Hashimoto’s thyroiditis." İstanbul Kuzey Klinikleri, 10, ss.353 - 358, 2023. 10.14744/nci.2022.22058 |
| ISNAD | Gul, Ali vd. "Mannose-binding lectin (MBL) levels in children with Hashimoto’s thyroiditis". İstanbul Kuzey Klinikleri 10/3 (2023), 353-358. https://doi.org/10.14744/nci.2022.22058 |
