Investigation of the anticancer effects of some plant seed oils with medicinal uses

Yener KURMAN, (Düzce Üniversitesi, Tıp Fakültesi, Tıbbi Biyoloji Anabilim Dalı, Düzce, Türkiye)
Görkem DÜLGER, (Düzce Üniversitesi, Tıp Fakültesi, Tıbbi Biyoloji Anabilim Dalı, Düzce, Türkiye)
Özge PASİN (Bezmialem Üniversitesi, Biyoistatistik Anabilim Dalı, İstanbul, Türkiye)
Journal of research in pharmacy (online)
12 0
Yıl: 2023 Cilt: 27 Sayı: 4 Sayfa Aralığı: 1594 - 1604 Metin Dili: İngilizce DOI: 10.29228/jrp.444 İndeks Tarihi: 28-07-2023

Investigation of the anticancer effects of some plant seed oils with medicinal uses

Öz:
Cancer is an important health problem and responsible for a significant number of deaths worldwide. Chemotherapy resistance and related side effects prevent cancer treatment from reaching the desired level. In this study, we aimed to investigate the anti-cancer properties of Carthamus tinctorius, Salvia hispanica and Linum usitatissimum seed oils on hepatocellular (HepG2), colorectal (HCT-116) and gastric carcinoma (AGS) cell lines. Human umbilical vein endothelial cells (HUVECs) were used as control cell group. Cell viability of HepG2, HCT-116, AGS and HUVECs was determined by MTT method after treatment with various concentrations of Carthamus tinctorius, Salvia hispanica and Linum usitatissimum. Colorimetric elisa kit was used for quantitative determination of caspase-3 activation. Antimigratory effect of Carthamus tinctorius and Salvia hispanica were investigated by wound healing assay. Carthamus tinctorius, Salvia hispanica and Linum usitatissimum seed oils significantly inhibited the proliferation of cancer cells. There was an insignificant decrease in the viability of HUVEC cells after seed oils treatments. Migration of HepG2 and AGS cells significantly suppressed by treatment of Salvia hispanica and Carthamus tinctorius respectively. Salvia hispanica and Carthamus tinctorius significantly increased caspase-3 activation in cancer cells. Our results showed that Carthamus tinctorius, Salvia hispanica and Linum usitatissimum exhibited a selective cytotoxicity against HepG2, HCT-116 and AGS cells without damaging normal cells.
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APA KURMAN Y, DÜLGER G, pasin o (2023). Investigation of the anticancer effects of some plant seed oils with medicinal uses. , 1594 - 1604. 10.29228/jrp.444
Chicago KURMAN YENER,DÜLGER Görkem,pasin ozge Investigation of the anticancer effects of some plant seed oils with medicinal uses. (2023): 1594 - 1604. 10.29228/jrp.444
MLA KURMAN YENER,DÜLGER Görkem,pasin ozge Investigation of the anticancer effects of some plant seed oils with medicinal uses. , 2023, ss.1594 - 1604. 10.29228/jrp.444
AMA KURMAN Y,DÜLGER G,pasin o Investigation of the anticancer effects of some plant seed oils with medicinal uses. . 2023; 1594 - 1604. 10.29228/jrp.444
Vancouver KURMAN Y,DÜLGER G,pasin o Investigation of the anticancer effects of some plant seed oils with medicinal uses. . 2023; 1594 - 1604. 10.29228/jrp.444
IEEE KURMAN Y,DÜLGER G,pasin o "Investigation of the anticancer effects of some plant seed oils with medicinal uses." , ss.1594 - 1604, 2023. 10.29228/jrp.444
ISNAD KURMAN, YENER vd. "Investigation of the anticancer effects of some plant seed oils with medicinal uses". (2023), 1594-1604. https://doi.org/10.29228/jrp.444
APA KURMAN Y, DÜLGER G, pasin o (2023). Investigation of the anticancer effects of some plant seed oils with medicinal uses. Journal of research in pharmacy (online), 27(4), 1594 - 1604. 10.29228/jrp.444
Chicago KURMAN YENER,DÜLGER Görkem,pasin ozge Investigation of the anticancer effects of some plant seed oils with medicinal uses. Journal of research in pharmacy (online) 27, no.4 (2023): 1594 - 1604. 10.29228/jrp.444
MLA KURMAN YENER,DÜLGER Görkem,pasin ozge Investigation of the anticancer effects of some plant seed oils with medicinal uses. Journal of research in pharmacy (online), vol.27, no.4, 2023, ss.1594 - 1604. 10.29228/jrp.444
AMA KURMAN Y,DÜLGER G,pasin o Investigation of the anticancer effects of some plant seed oils with medicinal uses. Journal of research in pharmacy (online). 2023; 27(4): 1594 - 1604. 10.29228/jrp.444
Vancouver KURMAN Y,DÜLGER G,pasin o Investigation of the anticancer effects of some plant seed oils with medicinal uses. Journal of research in pharmacy (online). 2023; 27(4): 1594 - 1604. 10.29228/jrp.444
IEEE KURMAN Y,DÜLGER G,pasin o "Investigation of the anticancer effects of some plant seed oils with medicinal uses." Journal of research in pharmacy (online), 27, ss.1594 - 1604, 2023. 10.29228/jrp.444
ISNAD KURMAN, YENER vd. "Investigation of the anticancer effects of some plant seed oils with medicinal uses". Journal of research in pharmacy (online) 27/4 (2023), 1594-1604. https://doi.org/10.29228/jrp.444
Sayfa Oluşturulma Tarihi
27-11-2023 14:52

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