INVESTIGATION OF SUBSTANTIA NIGRA HYPERECHOGENICITY BY TRANSCRANIAL SONOGRAPHY IN PATIENTS WITH ESSENTIAL TREMOR
Yıl: 2023 Cilt: 6 Sayı: 2 Sayfa Aralığı: 231 - 234 Metin Dili: İngilizce DOI: 10.53446/actamednicomedia.1219434 İndeks Tarihi: 30-07-2023
INVESTIGATION OF SUBSTANTIA NIGRA HYPERECHOGENICITY BY TRANSCRANIAL SONOGRAPHY IN PATIENTS WITH ESSENTIAL TREMOR
Öz: Objective: Essential tremor (ET) is the most common movement disorder. ET diagnosis may precede future Parkinson’s disease. Substantia nigra hyperechogenicity in transcranial sonography (TCS) is associated with Parkinson’s disease. The underlying etiology of substantia nigra hyperechogenicity remains unclear. In this study, we aimed to investigate the significance of the substantia nigra hyperechogenicity in patients with essential tremor. Methods: A total of 55 patients with ET and 60 matched controls underwent TCS. The hyperechogenic area was measured in the SN. Approximately ten years after their baseline TCS, all patients were inquired about their current condition, treatment, and medications to determine whether they had received a diagnosis of PD. Results: A total of 15 subjects were excluded due to insufficient image acquisition. The echogenic area of the SN ranged from 0.01 to 0.86 cm2 (mean 0.25±0.15) in the patient group and from 0.02 to 0.72 cm2 (mean 0.15±0.16) in the control group. Patients with ET had a significantly larger echogenic area than controls (p=0.001). 47% (26/55) of the patients have hyperechogenic SN, whereas only 15 % (9/60) of healthy controls have hyperechogenicity in the substantia nigra. None of the patients reported having a change in their diagnoses of ET. Conclusions: The results of this study show that SN hyperechogenicity is increased in patients with ET. Transcranial sonography may contribute to understanding the pathophysiology of ET.
Anahtar Kelime: ESANSİYEL TREMOR HASTALARINDA TRANSKRANİYAL SONOGRAFİ İLE SUBSTANTİA NİGRA HİPEREKOJENİTESİNİN ARAŞTIRILMASI
Öz: Amaç: Esansiyel tremor (ET) en sık görülen hareket bozukluğudur. ET ayrı bir hastalık olarak kabul edilse de, klinik takipte ET tanılı vakaların Parkinson Hastalığına (PH) ilerleyebildiği bilinmektedir. Transkraniyal sonografide (TKS) Substantia nigra (SN) hiperekojenitesi saptanması, PH ile ilişkili bulunmuştur. Ancak bu radyolojik bulgunun etiyolojisi ve klinik anlamı belirsizliğini korumaktadır. Biz de bu çalışmada esansiyel tremorlu hastalarda SN hiperekojenisitenin önemini araştırmayı amaçladık. Yöntem: Bu çalışmada ET tanısı olan toplam 55 hastaya ve yaşları benzer 60 kontrole TKS uygulandı ve SN hipekojeniteleri ölçüldü. Başlangıç TKS'lerinden yaklaşık on yıl sonra, tüm hastalara tekrar ulaşıldı ve PD teşhisi alıp almadıkları, mevcut durumları, tedavileri ve ilaçları hakkında sorular soruldu. Bulgular: Çalışmaya dahil edilen 115 hastadan 15’i yetersiz görüntü kalitesi nedeniyle çalışmadan dışlandı. SN'nin ekojenik alanı hasta grubunda 0,01 ile 0,86 cm2 (ortalama 0,25±0,15), kontrol grubunda ise 0,02 ile 0,72 cm2 (ortalama 0,15±0,16) arasında değişiyordu. ET'li hastalarda kontrollere göre anlamlı ölçüde daha büyük bir ekojenik alan ölçüldü (p=0,001). Hastaların %47'si (26/55) hiperekojenik SN'ye sahipken, sağlıklı kontrollerin sadece %15'i (9/60) substantia nigra'da hiperekojeniteye sahipti. Hastaların hiçbiri takipte ET tanılarında bir değişiklik olduğunu bildirmedi. Sonuç: Bu çalışmanın sonuçları, ET'li hastalarda SN hiperekojenitesinin arttığını göstermektedir. Transkraniyal sonografi ET patofizyolojisini anlamaya katkı sağlayabilir.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | Öztop Çakmak Ö, Candan F, Aydin Canturk I, Arı Sevingil s, Özkan A, Özkan E, ışık n (2023). INVESTIGATION OF SUBSTANTIA NIGRA HYPERECHOGENICITY BY TRANSCRANIAL SONOGRAPHY IN PATIENTS WITH ESSENTIAL TREMOR. , 231 - 234. 10.53446/actamednicomedia.1219434 |
| Chicago | Öztop Çakmak Özgür,Candan Fatma,Aydin Canturk Ilknur,Arı Sevingil semra,Özkan Adile,Özkan Esra,ışık nihal INVESTIGATION OF SUBSTANTIA NIGRA HYPERECHOGENICITY BY TRANSCRANIAL SONOGRAPHY IN PATIENTS WITH ESSENTIAL TREMOR. (2023): 231 - 234. 10.53446/actamednicomedia.1219434 |
| MLA | Öztop Çakmak Özgür,Candan Fatma,Aydin Canturk Ilknur,Arı Sevingil semra,Özkan Adile,Özkan Esra,ışık nihal INVESTIGATION OF SUBSTANTIA NIGRA HYPERECHOGENICITY BY TRANSCRANIAL SONOGRAPHY IN PATIENTS WITH ESSENTIAL TREMOR. , 2023, ss.231 - 234. 10.53446/actamednicomedia.1219434 |
| AMA | Öztop Çakmak Ö,Candan F,Aydin Canturk I,Arı Sevingil s,Özkan A,Özkan E,ışık n INVESTIGATION OF SUBSTANTIA NIGRA HYPERECHOGENICITY BY TRANSCRANIAL SONOGRAPHY IN PATIENTS WITH ESSENTIAL TREMOR. . 2023; 231 - 234. 10.53446/actamednicomedia.1219434 |
| Vancouver | Öztop Çakmak Ö,Candan F,Aydin Canturk I,Arı Sevingil s,Özkan A,Özkan E,ışık n INVESTIGATION OF SUBSTANTIA NIGRA HYPERECHOGENICITY BY TRANSCRANIAL SONOGRAPHY IN PATIENTS WITH ESSENTIAL TREMOR. . 2023; 231 - 234. 10.53446/actamednicomedia.1219434 |
| IEEE | Öztop Çakmak Ö,Candan F,Aydin Canturk I,Arı Sevingil s,Özkan A,Özkan E,ışık n "INVESTIGATION OF SUBSTANTIA NIGRA HYPERECHOGENICITY BY TRANSCRANIAL SONOGRAPHY IN PATIENTS WITH ESSENTIAL TREMOR." , ss.231 - 234, 2023. 10.53446/actamednicomedia.1219434 |
| ISNAD | Öztop Çakmak, Özgür vd. "INVESTIGATION OF SUBSTANTIA NIGRA HYPERECHOGENICITY BY TRANSCRANIAL SONOGRAPHY IN PATIENTS WITH ESSENTIAL TREMOR". (2023), 231-234. https://doi.org/10.53446/actamednicomedia.1219434 |
| APA | Öztop Çakmak Ö, Candan F, Aydin Canturk I, Arı Sevingil s, Özkan A, Özkan E, ışık n (2023). INVESTIGATION OF SUBSTANTIA NIGRA HYPERECHOGENICITY BY TRANSCRANIAL SONOGRAPHY IN PATIENTS WITH ESSENTIAL TREMOR. Acta Medica Nicomedia, 6(2), 231 - 234. 10.53446/actamednicomedia.1219434 |
| Chicago | Öztop Çakmak Özgür,Candan Fatma,Aydin Canturk Ilknur,Arı Sevingil semra,Özkan Adile,Özkan Esra,ışık nihal INVESTIGATION OF SUBSTANTIA NIGRA HYPERECHOGENICITY BY TRANSCRANIAL SONOGRAPHY IN PATIENTS WITH ESSENTIAL TREMOR. Acta Medica Nicomedia 6, no.2 (2023): 231 - 234. 10.53446/actamednicomedia.1219434 |
| MLA | Öztop Çakmak Özgür,Candan Fatma,Aydin Canturk Ilknur,Arı Sevingil semra,Özkan Adile,Özkan Esra,ışık nihal INVESTIGATION OF SUBSTANTIA NIGRA HYPERECHOGENICITY BY TRANSCRANIAL SONOGRAPHY IN PATIENTS WITH ESSENTIAL TREMOR. Acta Medica Nicomedia, vol.6, no.2, 2023, ss.231 - 234. 10.53446/actamednicomedia.1219434 |
| AMA | Öztop Çakmak Ö,Candan F,Aydin Canturk I,Arı Sevingil s,Özkan A,Özkan E,ışık n INVESTIGATION OF SUBSTANTIA NIGRA HYPERECHOGENICITY BY TRANSCRANIAL SONOGRAPHY IN PATIENTS WITH ESSENTIAL TREMOR. Acta Medica Nicomedia. 2023; 6(2): 231 - 234. 10.53446/actamednicomedia.1219434 |
| Vancouver | Öztop Çakmak Ö,Candan F,Aydin Canturk I,Arı Sevingil s,Özkan A,Özkan E,ışık n INVESTIGATION OF SUBSTANTIA NIGRA HYPERECHOGENICITY BY TRANSCRANIAL SONOGRAPHY IN PATIENTS WITH ESSENTIAL TREMOR. Acta Medica Nicomedia. 2023; 6(2): 231 - 234. 10.53446/actamednicomedia.1219434 |
| IEEE | Öztop Çakmak Ö,Candan F,Aydin Canturk I,Arı Sevingil s,Özkan A,Özkan E,ışık n "INVESTIGATION OF SUBSTANTIA NIGRA HYPERECHOGENICITY BY TRANSCRANIAL SONOGRAPHY IN PATIENTS WITH ESSENTIAL TREMOR." Acta Medica Nicomedia, 6, ss.231 - 234, 2023. 10.53446/actamednicomedia.1219434 |
| ISNAD | Öztop Çakmak, Özgür vd. "INVESTIGATION OF SUBSTANTIA NIGRA HYPERECHOGENICITY BY TRANSCRANIAL SONOGRAPHY IN PATIENTS WITH ESSENTIAL TREMOR". Acta Medica Nicomedia 6/2 (2023), 231-234. https://doi.org/10.53446/actamednicomedia.1219434 |
