Does apocynin increase liver regeneration in the partial hepatectomy model?

Background/aim: Hepayocyte loss may develop secondary to liver surgery and at this point liver regeneration plays a significant act in terms of liver reserve. The purpose of this research was to investigate the efficacy of apocynin on liver regeneration and preservation after partial hepatectomy in rats. Materials and methods: A total of 32 rats, have been divided into 4 groups (n: 8) for hepatectomy model. Inflammatory and antiinflammatory parameters were measured from blood and liver tissue samples. In addition, the effects of apocynin were examined immunohistochemically and histopathologically from liver tissue. Results: In liver tissue samples, a significant difference has been found in glutathione peroxidase, total nitrite, catalase, oxidative stress index, total antioxidant and total oxidant status between sham and hepatectomy groups. A significant difference has been achieved between hepatectomy and posthepatectomy-Apocynin in terms of glutathione peroxidase and oxidative stress index. Total antioxidant status, oxidative stress index, and total oxidant status were significantly different only between the sham and the hepatectomy groups. Statistical differences were found between sham and hepatectomy groups and between hepatectomy and pre+post-hepatectomy-Apocynin groups in terms of serum glutathione, malondialdehyde, total nitrite, and L-Arginine. There were significant differences between the sham and hepatectomy groups, between hepatectomy and posthepatectomy-apocynin groups, between posthepatctomy-apocynin and pre+posthepatectomy-apocynin groups in terms of sinusoidal dilatation, intracytoplasmic vacuolization and glycogen loss (p < 0.001), in all histopathologic parameters except sinusoidal dilatation (p < 0.05). However, significant Ki–67 increases have been elaborated in hepatectomy, posthepatectomy-apocynin, and pre+posthepatectomy-apocynin groups compared to sham group (p < 0.001), in pre+posthepatectomy apocynin group compared to hepatectomy and posthepatectomy-apocynin groups (p < 0.001). Conclusion: Histopathology, immunohistochemistry, and biochemistry results of this study revealed that apocynin has a protective effect on enhancing liver regeneration in partial hepatectomy cases in rats.

Anahtar Kelime: Antioxidant apocynin hepatectomy liver regeneration oxidative stress rats

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	bilgic y, kanat b, Ozhan O, Yıldız A, AKSUNGUR Z, erdemli m, Vardi N, Turkoz Y, Akbulut S, Köse A, Parlakpinar H (2023). Does apocynin increase liver regeneration in the partial hepatectomy model?. , 647 - 658. 10.55730/1300-0144.5627
Chicago	bilgic yılmaz,kanat burhan hakan,Ozhan Onural,Yıldız Azibe,AKSUNGUR ZEYNEP,erdemli mehmet erman,Vardi Nigar,Turkoz Yusuf,Akbulut Sami,Köse Adem,Parlakpinar Hakan Does apocynin increase liver regeneration in the partial hepatectomy model?. (2023): 647 - 658. 10.55730/1300-0144.5627
MLA	bilgic yılmaz,kanat burhan hakan,Ozhan Onural,Yıldız Azibe,AKSUNGUR ZEYNEP,erdemli mehmet erman,Vardi Nigar,Turkoz Yusuf,Akbulut Sami,Köse Adem,Parlakpinar Hakan Does apocynin increase liver regeneration in the partial hepatectomy model?. , 2023, ss.647 - 658. 10.55730/1300-0144.5627
AMA	bilgic y,kanat b,Ozhan O,Yıldız A,AKSUNGUR Z,erdemli m,Vardi N,Turkoz Y,Akbulut S,Köse A,Parlakpinar H Does apocynin increase liver regeneration in the partial hepatectomy model?. . 2023; 647 - 658. 10.55730/1300-0144.5627
Vancouver	bilgic y,kanat b,Ozhan O,Yıldız A,AKSUNGUR Z,erdemli m,Vardi N,Turkoz Y,Akbulut S,Köse A,Parlakpinar H Does apocynin increase liver regeneration in the partial hepatectomy model?. . 2023; 647 - 658. 10.55730/1300-0144.5627
IEEE	bilgic y,kanat b,Ozhan O,Yıldız A,AKSUNGUR Z,erdemli m,Vardi N,Turkoz Y,Akbulut S,Köse A,Parlakpinar H "Does apocynin increase liver regeneration in the partial hepatectomy model?." , ss.647 - 658, 2023. 10.55730/1300-0144.5627
ISNAD	bilgic, yılmaz vd. "Does apocynin increase liver regeneration in the partial hepatectomy model?". (2023), 647-658. https://doi.org/10.55730/1300-0144.5627

APA	bilgic y, kanat b, Ozhan O, Yıldız A, AKSUNGUR Z, erdemli m, Vardi N, Turkoz Y, Akbulut S, Köse A, Parlakpinar H (2023). Does apocynin increase liver regeneration in the partial hepatectomy model?. Turkish Journal of Medical Sciences, 53(3), 647 - 658. 10.55730/1300-0144.5627
Chicago	bilgic yılmaz,kanat burhan hakan,Ozhan Onural,Yıldız Azibe,AKSUNGUR ZEYNEP,erdemli mehmet erman,Vardi Nigar,Turkoz Yusuf,Akbulut Sami,Köse Adem,Parlakpinar Hakan Does apocynin increase liver regeneration in the partial hepatectomy model?. Turkish Journal of Medical Sciences 53, no.3 (2023): 647 - 658. 10.55730/1300-0144.5627
MLA	bilgic yılmaz,kanat burhan hakan,Ozhan Onural,Yıldız Azibe,AKSUNGUR ZEYNEP,erdemli mehmet erman,Vardi Nigar,Turkoz Yusuf,Akbulut Sami,Köse Adem,Parlakpinar Hakan Does apocynin increase liver regeneration in the partial hepatectomy model?. Turkish Journal of Medical Sciences, vol.53, no.3, 2023, ss.647 - 658. 10.55730/1300-0144.5627
AMA	bilgic y,kanat b,Ozhan O,Yıldız A,AKSUNGUR Z,erdemli m,Vardi N,Turkoz Y,Akbulut S,Köse A,Parlakpinar H Does apocynin increase liver regeneration in the partial hepatectomy model?. Turkish Journal of Medical Sciences. 2023; 53(3): 647 - 658. 10.55730/1300-0144.5627
Vancouver	bilgic y,kanat b,Ozhan O,Yıldız A,AKSUNGUR Z,erdemli m,Vardi N,Turkoz Y,Akbulut S,Köse A,Parlakpinar H Does apocynin increase liver regeneration in the partial hepatectomy model?. Turkish Journal of Medical Sciences. 2023; 53(3): 647 - 658. 10.55730/1300-0144.5627
IEEE	bilgic y,kanat b,Ozhan O,Yıldız A,AKSUNGUR Z,erdemli m,Vardi N,Turkoz Y,Akbulut S,Köse A,Parlakpinar H "Does apocynin increase liver regeneration in the partial hepatectomy model?." Turkish Journal of Medical Sciences, 53, ss.647 - 658, 2023. 10.55730/1300-0144.5627
ISNAD	bilgic, yılmaz vd. "Does apocynin increase liver regeneration in the partial hepatectomy model?". Turkish Journal of Medical Sciences 53/3 (2023), 647-658. https://doi.org/10.55730/1300-0144.5627