Investigation of Igf-1, Igf-Bp3 and Igf-Bp5 levels in umbilical cord blood of infants with developmental dysplasia of the hip

Demirel, Esra; Şenocak, Eyüp; Şahin, Ali; Kadıoğlu, Berrin Göktuğ; gündüz, özlem; Cimilli senocak, Gamze nur

doi:10.55730/1300-0144.5628

Investigation of Igf-1, Igf-Bp3 and Igf-Bp5 levels in umbilical cord blood of infants with developmental dysplasia of the hip

Esra DEMİREL, (Erzurum Eğitim ve Araştırma Hastanesi, Ortopedi ve Travmatoloji Bölümü, Erzurum, Türkiye)

Eyüp ŞENOCAK, (Erzurum Eğitim ve Araştırma Hastanesi, Ortopedi ve Travmatoloji Bölümü, Erzurum, Türkiye)

Gamze nur Cimilli senocak, (Atatürk Üniversitesi, Tıp Fakültesi, Kadın Hastalıkları ve Doğum Anabilim Dalı, Erzurum, Türkiye)

Ali ŞAHİN, (Ankara Şehir Hastanesi, Ortopedi ve Travmatoloji Bölümü, Ankara, Türkiye)

Berrin GÖKTUĞ KADIOĞLU, (Erzurum Eğitim ve Araştırma Hastanesi, Kadın Hastalıkları ve Doğum Bölümü, Erzurum, Türkiye)

Özlem GÜNDÜZ (Erzurum Eğitim ve Araştırma Hastanesi, Kadın Hastalıkları ve Doğum Bölümü, Erzurum, Türkiye)

Turkish Journal of Medical Sciences

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Yıl: 2023 Cilt: 53 Sayı: 3 Sayfa Aralığı: 659 - 665 Metin Dili: İngilizce DOI: 10.55730/1300-0144.5628 İndeks Tarihi: 01-08-2023

Investigation of Igf-1, Igf-Bp3 and Igf-Bp5 levels in umbilical cord blood of infants with developmental dysplasia of the hip

Öz:

Background/aim: IGF-1 (insulin-like growth factor-1) is an important regulator of bone formation. Its deficiency has been associated with fetal growth disorders and hip dysplasia. The aim of this study was to evaluate whether IGF-1, IGF-BP3 (insulin like growth factor- binding protein 3), and IGF-BP5 levels in the umbilical cord blood can be predictive for early diagnosis of DDH. Materials and methods: Umbilical cord blood samples were collected from 860 mothers with pregnancies at high risk for DDH between October 2020 and January 2021. Mothers at 37–42 weeks of gestation, with risk factors for DDH, who delivered healthy infants were included. Blood samples were collected during delivery. Each eligible infant was medically followed up and underwent a hip ultrasound in the postnatal 2nd or 3rd month. Infants diagnosed with DDH were matched with a healthy cohort in terms of sex, birth weight, maternal age, and gestational week, and the IGF-1, IGF-BP3 and IGF-BP5 levels were studied and compared. Results: Evaluation was made of 20 infants diagnosed with DDH and 60 healthy infants. Of the total 80 infants, 72.5% were female. The umbilical cord blood levels of IGF-1 and IGF-BP3 were similar in both groups. The IGF-BP5 values were significantly lower in the DDH patient group. Except for DDH diagnosis, the other categorical variables of the study did not appear to influence the levels of any of the IGFs. Conclusion: Umbilical blood samples could potentially help diagnose DDH. The levels of IGF-BP5 were shown to be significantly lower in infants with DDH.

Anahtar Kelime: IGF-1 IGF-BP3 IGF-BP5 developmental hip dysplasia umbilical cord blood

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Demirel E, Şenocak E, Cimilli senocak G, Şahin A, Kadıoğlu B, gündüz ö (2023). Investigation of Igf-1, Igf-Bp3 and Igf-Bp5 levels in umbilical cord blood of infants with developmental dysplasia of the hip. , 659 - 665. 10.55730/1300-0144.5628
Chicago	Demirel Esra,Şenocak Eyüp,Cimilli senocak Gamze nur,Şahin Ali,Kadıoğlu Berrin Göktuğ,gündüz özlem Investigation of Igf-1, Igf-Bp3 and Igf-Bp5 levels in umbilical cord blood of infants with developmental dysplasia of the hip. (2023): 659 - 665. 10.55730/1300-0144.5628
MLA	Demirel Esra,Şenocak Eyüp,Cimilli senocak Gamze nur,Şahin Ali,Kadıoğlu Berrin Göktuğ,gündüz özlem Investigation of Igf-1, Igf-Bp3 and Igf-Bp5 levels in umbilical cord blood of infants with developmental dysplasia of the hip. , 2023, ss.659 - 665. 10.55730/1300-0144.5628
AMA	Demirel E,Şenocak E,Cimilli senocak G,Şahin A,Kadıoğlu B,gündüz ö Investigation of Igf-1, Igf-Bp3 and Igf-Bp5 levels in umbilical cord blood of infants with developmental dysplasia of the hip. . 2023; 659 - 665. 10.55730/1300-0144.5628
Vancouver	Demirel E,Şenocak E,Cimilli senocak G,Şahin A,Kadıoğlu B,gündüz ö Investigation of Igf-1, Igf-Bp3 and Igf-Bp5 levels in umbilical cord blood of infants with developmental dysplasia of the hip. . 2023; 659 - 665. 10.55730/1300-0144.5628
IEEE	Demirel E,Şenocak E,Cimilli senocak G,Şahin A,Kadıoğlu B,gündüz ö "Investigation of Igf-1, Igf-Bp3 and Igf-Bp5 levels in umbilical cord blood of infants with developmental dysplasia of the hip." , ss.659 - 665, 2023. 10.55730/1300-0144.5628
ISNAD	Demirel, Esra vd. "Investigation of Igf-1, Igf-Bp3 and Igf-Bp5 levels in umbilical cord blood of infants with developmental dysplasia of the hip". (2023), 659-665. https://doi.org/10.55730/1300-0144.5628

APA	Demirel E, Şenocak E, Cimilli senocak G, Şahin A, Kadıoğlu B, gündüz ö (2023). Investigation of Igf-1, Igf-Bp3 and Igf-Bp5 levels in umbilical cord blood of infants with developmental dysplasia of the hip. Turkish Journal of Medical Sciences, 53(3), 659 - 665. 10.55730/1300-0144.5628
Chicago	Demirel Esra,Şenocak Eyüp,Cimilli senocak Gamze nur,Şahin Ali,Kadıoğlu Berrin Göktuğ,gündüz özlem Investigation of Igf-1, Igf-Bp3 and Igf-Bp5 levels in umbilical cord blood of infants with developmental dysplasia of the hip. Turkish Journal of Medical Sciences 53, no.3 (2023): 659 - 665. 10.55730/1300-0144.5628
MLA	Demirel Esra,Şenocak Eyüp,Cimilli senocak Gamze nur,Şahin Ali,Kadıoğlu Berrin Göktuğ,gündüz özlem Investigation of Igf-1, Igf-Bp3 and Igf-Bp5 levels in umbilical cord blood of infants with developmental dysplasia of the hip. Turkish Journal of Medical Sciences, vol.53, no.3, 2023, ss.659 - 665. 10.55730/1300-0144.5628
AMA	Demirel E,Şenocak E,Cimilli senocak G,Şahin A,Kadıoğlu B,gündüz ö Investigation of Igf-1, Igf-Bp3 and Igf-Bp5 levels in umbilical cord blood of infants with developmental dysplasia of the hip. Turkish Journal of Medical Sciences. 2023; 53(3): 659 - 665. 10.55730/1300-0144.5628
Vancouver	Demirel E,Şenocak E,Cimilli senocak G,Şahin A,Kadıoğlu B,gündüz ö Investigation of Igf-1, Igf-Bp3 and Igf-Bp5 levels in umbilical cord blood of infants with developmental dysplasia of the hip. Turkish Journal of Medical Sciences. 2023; 53(3): 659 - 665. 10.55730/1300-0144.5628
IEEE	Demirel E,Şenocak E,Cimilli senocak G,Şahin A,Kadıoğlu B,gündüz ö "Investigation of Igf-1, Igf-Bp3 and Igf-Bp5 levels in umbilical cord blood of infants with developmental dysplasia of the hip." Turkish Journal of Medical Sciences, 53, ss.659 - 665, 2023. 10.55730/1300-0144.5628
ISNAD	Demirel, Esra vd. "Investigation of Igf-1, Igf-Bp3 and Igf-Bp5 levels in umbilical cord blood of infants with developmental dysplasia of the hip". Turkish Journal of Medical Sciences 53/3 (2023), 659-665. https://doi.org/10.55730/1300-0144.5628