Investigation of the value of hematological biomarkers in the clinical differential diagnosis of IgG4-RD

KARADENİZ, HAZAN; Avanoglu Guler, Aslihan; Kardaş, Rıza Can; KARADENİZ, MUZAFFER; Paşaoğlu, Hatice; Kucuk, Hamit; Goker, Berna; TUFAN, ABDURRAHMAN; öztürk, mehmet akif

doi:10.55730/1300-0144.5629

Investigation of the value of hematological biomarkers in the clinical differential diagnosis of IgG4-RD

Hazan KARADENİZ, (Gazi Üniversitesi, Tıp Fakültesi, İç Hastalıkları Bölümü, Romatoloji Anabilim Dalı, Ankara, Türkiye)

Aslıhan AVANOĞLU GÜLER, (Gazi Üniversitesi, Tıp Fakültesi, İç Hastalıkları Bölümü, Romatoloji Anabilim Dalı, Ankara, Türkiye)

Rıza Can KARDAŞ, (Gazi Üniversitesi, Tıp Fakültesi, İç Hastalıkları Bölümü, Romatoloji Anabilim Dalı, Ankara, Türkiye)

Muzaffer KARADENİZ, (Kızılcahamam Devlet Hastanesi, Kardiyoloji Bölümü, Ankara, Türkiye)

Hatice PAŞAOĞLU, (Gazi Üniversitesi, Tıp Fakültesi, Biyokimya Anabilim Dalı, Ankara, Türkiye)

Hamit KÜÇÜK, (Gazi Üniversitesi, Tıp Fakültesi, İç Hastalıkları Bölümü, Romatoloji Anabilim Dalı, Ankara, Türkiye)

Berna GÖKER, (Gazi Üniversitesi, Tıp Fakültesi, İç Hastalıkları Bölümü, Romatoloji Anabilim Dalı, Ankara, Türkiye)

Abdurrahman TUFAN, (Gazi Üniversitesi, Tıp Fakültesi, İç Hastalıkları Bölümü, Romatoloji Anabilim Dalı, Ankara, Türkiye)

Mehmet Akif ÖZTÜRK (Gazi Üniversitesi, Tıp Fakültesi, İç Hastalıkları Bölümü, Romatoloji Anabilim Dalı, Ankara, Türkiye)

Turkish Journal of Medical Sciences

4 1

Yıl: 2023 Cilt: 53 Sayı: 3 Sayfa Aralığı: 666 - 674 Metin Dili: İngilizce DOI: 10.55730/1300-0144.5629 İndeks Tarihi: 01-08-2023

Investigation of the value of hematological biomarkers in the clinical differential diagnosis of IgG4-RD

Öz:

Background/aim: IgG4- related disease (IgG4- RD) is a systemic fibroinflammatory disease whose pathogenesis has not been completely elucidated. Due to the novelty and complexity of the diagnostic criteria, it is difficult to distinguish from the diseases included in the differential diagnosis without tissue biopsy. This study aimed to discover new biomarkers that can help for disease diagnosis and its differential diagnosis by reviewing the relationships between neutrophil-lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR), systemic immune-inflammation index (SII), and systemic inflammation response index (SIRI). Materials and methods: Thirty IgG4- RD, 38 granulomatous polyangiitis (GPA), and 46 sarcoidosis patients presenting to the Rheumatology Clinic meeting the criteria of 2019 American College of Rheumatology, 2012 International Chapel Hill and 1999 American Thoracic Society meeting, respectively, and 27 healthy control subjects were included. We collected data on complete blood count with automated differential values including NLR, PLR, SII, and SIRI. Results: The SII and PLR values were significantly higher in patients with IgG4-RD compared to healthy controls, (SII median (min- max) 572 (102–5583) vs. 434 (172–897), PLR median (min-max) 130 (56.8–546) vs. 104 (57.5- 253) p < 0.001). SII value was found to have a significant positive correlation with CRP in IgG4-RD disease (r = 0.371; p = 0.043). While SII, SIRI, NLR, PLR parameters were not significant between the IgG4-RD and sarcoidosis groups, SII, SIRI, NLR, PLR were significantly higher in patients with GPA than in IgG4-RD patients (p < 0.001). Conclusion: This is the first study to review the SII, SIRI, NLR, and PLR in IgG4-RD. The obtained results suggest that the SII could be used as a new tool, for differential diagnosis and activity of the IgG4-RD.

Anahtar Kelime: Systemic immune-inflammation index systemic inflammation response index neutrophil-lymphocyte ratio platelet lymphocyte ratio IgG4-related disease

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	KARADENİZ H, Avanoglu Guler A, Kardaş R, KARADENİZ M, Paşaoğlu H, Kucuk H, Goker B, TUFAN A, öztürk m (2023). Investigation of the value of hematological biomarkers in the clinical differential diagnosis of IgG4-RD. , 666 - 674. 10.55730/1300-0144.5629
Chicago	KARADENİZ HAZAN,Avanoglu Guler Aslihan,Kardaş Rıza Can,KARADENİZ MUZAFFER,Paşaoğlu Hatice,Kucuk Hamit,Goker Berna,TUFAN ABDURRAHMAN,öztürk mehmet akif Investigation of the value of hematological biomarkers in the clinical differential diagnosis of IgG4-RD. (2023): 666 - 674. 10.55730/1300-0144.5629
MLA	KARADENİZ HAZAN,Avanoglu Guler Aslihan,Kardaş Rıza Can,KARADENİZ MUZAFFER,Paşaoğlu Hatice,Kucuk Hamit,Goker Berna,TUFAN ABDURRAHMAN,öztürk mehmet akif Investigation of the value of hematological biomarkers in the clinical differential diagnosis of IgG4-RD. , 2023, ss.666 - 674. 10.55730/1300-0144.5629
AMA	KARADENİZ H,Avanoglu Guler A,Kardaş R,KARADENİZ M,Paşaoğlu H,Kucuk H,Goker B,TUFAN A,öztürk m Investigation of the value of hematological biomarkers in the clinical differential diagnosis of IgG4-RD. . 2023; 666 - 674. 10.55730/1300-0144.5629
Vancouver	KARADENİZ H,Avanoglu Guler A,Kardaş R,KARADENİZ M,Paşaoğlu H,Kucuk H,Goker B,TUFAN A,öztürk m Investigation of the value of hematological biomarkers in the clinical differential diagnosis of IgG4-RD. . 2023; 666 - 674. 10.55730/1300-0144.5629
IEEE	KARADENİZ H,Avanoglu Guler A,Kardaş R,KARADENİZ M,Paşaoğlu H,Kucuk H,Goker B,TUFAN A,öztürk m "Investigation of the value of hematological biomarkers in the clinical differential diagnosis of IgG4-RD." , ss.666 - 674, 2023. 10.55730/1300-0144.5629
ISNAD	KARADENİZ, HAZAN vd. "Investigation of the value of hematological biomarkers in the clinical differential diagnosis of IgG4-RD". (2023), 666-674. https://doi.org/10.55730/1300-0144.5629

APA	KARADENİZ H, Avanoglu Guler A, Kardaş R, KARADENİZ M, Paşaoğlu H, Kucuk H, Goker B, TUFAN A, öztürk m (2023). Investigation of the value of hematological biomarkers in the clinical differential diagnosis of IgG4-RD. Turkish Journal of Medical Sciences, 53(3), 666 - 674. 10.55730/1300-0144.5629
Chicago	KARADENİZ HAZAN,Avanoglu Guler Aslihan,Kardaş Rıza Can,KARADENİZ MUZAFFER,Paşaoğlu Hatice,Kucuk Hamit,Goker Berna,TUFAN ABDURRAHMAN,öztürk mehmet akif Investigation of the value of hematological biomarkers in the clinical differential diagnosis of IgG4-RD. Turkish Journal of Medical Sciences 53, no.3 (2023): 666 - 674. 10.55730/1300-0144.5629
MLA	KARADENİZ HAZAN,Avanoglu Guler Aslihan,Kardaş Rıza Can,KARADENİZ MUZAFFER,Paşaoğlu Hatice,Kucuk Hamit,Goker Berna,TUFAN ABDURRAHMAN,öztürk mehmet akif Investigation of the value of hematological biomarkers in the clinical differential diagnosis of IgG4-RD. Turkish Journal of Medical Sciences, vol.53, no.3, 2023, ss.666 - 674. 10.55730/1300-0144.5629
AMA	KARADENİZ H,Avanoglu Guler A,Kardaş R,KARADENİZ M,Paşaoğlu H,Kucuk H,Goker B,TUFAN A,öztürk m Investigation of the value of hematological biomarkers in the clinical differential diagnosis of IgG4-RD. Turkish Journal of Medical Sciences. 2023; 53(3): 666 - 674. 10.55730/1300-0144.5629
Vancouver	KARADENİZ H,Avanoglu Guler A,Kardaş R,KARADENİZ M,Paşaoğlu H,Kucuk H,Goker B,TUFAN A,öztürk m Investigation of the value of hematological biomarkers in the clinical differential diagnosis of IgG4-RD. Turkish Journal of Medical Sciences. 2023; 53(3): 666 - 674. 10.55730/1300-0144.5629
IEEE	KARADENİZ H,Avanoglu Guler A,Kardaş R,KARADENİZ M,Paşaoğlu H,Kucuk H,Goker B,TUFAN A,öztürk m "Investigation of the value of hematological biomarkers in the clinical differential diagnosis of IgG4-RD." Turkish Journal of Medical Sciences, 53, ss.666 - 674, 2023. 10.55730/1300-0144.5629
ISNAD	KARADENİZ, HAZAN vd. "Investigation of the value of hematological biomarkers in the clinical differential diagnosis of IgG4-RD". Turkish Journal of Medical Sciences 53/3 (2023), 666-674. https://doi.org/10.55730/1300-0144.5629