Investigation of relationships between serum lactate, acute phase proteins, pro/ antiinflammatory cytokine levels, and metritis formation in Holstein dairy heifers

Avcılar, Talha; Koca, Davut; Nak, Yavuz; Sahin, Mustafa Eren; ozyigit, ozgur; Nak, Deniz

doi:10.55730/1300-0128.4284

Investigation of relationships between serum lactate, acute phase proteins, pro/ antiinflammatory cytokine levels, and metritis formation in Holstein dairy heifers

Talha AVCILAR, (Bursa Uludağ Üniversitesi, Veteriner Fakültesi, Jinekoloji ve Doğum Anabilim Dalı, Bursa, Türkiye)

Davut KOCA, (Van Yüzüncü Yıl Üniversitesi, Veteriner Fakültesi Jinekoloji ve Doğum Anabilim Dalı, Van, Türkiye)

Yavuz NAK, (Bursa Uludağ Üniversitesi, Veteriner Fakültesi, Jinekoloji ve Doğum Anabilim Dalı, Bursa, Türkiye)

Mustafa Eren ŞAHİN, (Bursa Uludağ Üniversitesi, Veteriner Fakültesi, Jinekoloji ve Doğum Anabilim Dalı, Bursa, Türkiye)

Musa Özgür ÖZYİĞİT, (Bursa Uludağ Üniversitesi, Veteriner Fakültesi, Patoloji Anabilim Dalı, Bursa, Türkiye)

Deniz NAK (Bursa Uludağ Üniversitesi, Veteriner Fakültesi, Jinekoloji ve Doğum Anabilim Dalı, Bursa, Türkiye)

Turkish Journal of Veterinary and Animal Sciences

4 0

Yıl: 2023 Cilt: 47 Sayı: 3 Sayfa Aralığı: 176 - 184 Metin Dili: İngilizce DOI: 10.55730/1300-0128.4284 İndeks Tarihi: 02-08-2023

Investigation of relationships between serum lactate, acute phase proteins, pro/ antiinflammatory cytokine levels, and metritis formation in Holstein dairy heifers

Öz:

The main purpose of this investigation was to identify and suggest suitable early screening inflammatory markers for the early diagnosis of uterine infections such as acute septic metritis (ASM) in the Holstein heifers. In addition, to achieve the above -mentioned aim, the objectives of the present study were tried to determine the relationship between blood serum lactate, acute phase proteins (APPs), pro/anti inflammatory cytokine levels, and metritis formation in Holstein heifers. For this purpose, 250 Holstein heifers which were 11–13 months old, were chosen as the study material. After heifers were conceived, blood serum samples were collected at the 8th and 4th weeks before the parturition. In the postpartum period, animals with ASM (n = 15) and healthy animals (n = 15) were identified, and blood serum samples were taken. Lactate, serum amyloid-A (SAA), haptoglobin (Hp), Interleukin-1beta (IL-1 β), IL-6, IL-8, IL-10, and tumor necrosis factor-alpha (TNF - α) levels were measured from these collected blood serum samples. Acute-phase proteins, lactate, and pro and anti inflammatory cytokine levels of healthy and animals with ASM were statistically compared. Heifers with metritis had a significantly greater concentration of IL-6 and SAA versus healthy heifers in the prepartum 8th week. In addition, it was determined that IL-6, IL-1β, IL-10, TNF-α, and SAA levels were significantly higher in the 4th week before parturition in the ASM group than those of the healthy group. When all these findings are evaluated together, this study suggested that IL-6, and IL-10, can be used as early biomarkers in the prepartum preliminary diagnosis of postpartum important inflammatory processes such as ASM.

Anahtar Kelime: Heifer metritis cytokines acute phase proteins lactate

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Avcılar T, Koca D, Nak Y, Sahin M, ozyigit o, Nak D (2023). Investigation of relationships between serum lactate, acute phase proteins, pro/ antiinflammatory cytokine levels, and metritis formation in Holstein dairy heifers. , 176 - 184. 10.55730/1300-0128.4284
Chicago	Avcılar Talha,Koca Davut,Nak Yavuz,Sahin Mustafa Eren,ozyigit ozgur,Nak Deniz Investigation of relationships between serum lactate, acute phase proteins, pro/ antiinflammatory cytokine levels, and metritis formation in Holstein dairy heifers. (2023): 176 - 184. 10.55730/1300-0128.4284
MLA	Avcılar Talha,Koca Davut,Nak Yavuz,Sahin Mustafa Eren,ozyigit ozgur,Nak Deniz Investigation of relationships between serum lactate, acute phase proteins, pro/ antiinflammatory cytokine levels, and metritis formation in Holstein dairy heifers. , 2023, ss.176 - 184. 10.55730/1300-0128.4284
AMA	Avcılar T,Koca D,Nak Y,Sahin M,ozyigit o,Nak D Investigation of relationships between serum lactate, acute phase proteins, pro/ antiinflammatory cytokine levels, and metritis formation in Holstein dairy heifers. . 2023; 176 - 184. 10.55730/1300-0128.4284
Vancouver	Avcılar T,Koca D,Nak Y,Sahin M,ozyigit o,Nak D Investigation of relationships between serum lactate, acute phase proteins, pro/ antiinflammatory cytokine levels, and metritis formation in Holstein dairy heifers. . 2023; 176 - 184. 10.55730/1300-0128.4284
IEEE	Avcılar T,Koca D,Nak Y,Sahin M,ozyigit o,Nak D "Investigation of relationships between serum lactate, acute phase proteins, pro/ antiinflammatory cytokine levels, and metritis formation in Holstein dairy heifers." , ss.176 - 184, 2023. 10.55730/1300-0128.4284
ISNAD	Avcılar, Talha vd. "Investigation of relationships between serum lactate, acute phase proteins, pro/ antiinflammatory cytokine levels, and metritis formation in Holstein dairy heifers". (2023), 176-184. https://doi.org/10.55730/1300-0128.4284

APA	Avcılar T, Koca D, Nak Y, Sahin M, ozyigit o, Nak D (2023). Investigation of relationships between serum lactate, acute phase proteins, pro/ antiinflammatory cytokine levels, and metritis formation in Holstein dairy heifers. Turkish Journal of Veterinary and Animal Sciences, 47(3), 176 - 184. 10.55730/1300-0128.4284
Chicago	Avcılar Talha,Koca Davut,Nak Yavuz,Sahin Mustafa Eren,ozyigit ozgur,Nak Deniz Investigation of relationships between serum lactate, acute phase proteins, pro/ antiinflammatory cytokine levels, and metritis formation in Holstein dairy heifers. Turkish Journal of Veterinary and Animal Sciences 47, no.3 (2023): 176 - 184. 10.55730/1300-0128.4284
MLA	Avcılar Talha,Koca Davut,Nak Yavuz,Sahin Mustafa Eren,ozyigit ozgur,Nak Deniz Investigation of relationships between serum lactate, acute phase proteins, pro/ antiinflammatory cytokine levels, and metritis formation in Holstein dairy heifers. Turkish Journal of Veterinary and Animal Sciences, vol.47, no.3, 2023, ss.176 - 184. 10.55730/1300-0128.4284
AMA	Avcılar T,Koca D,Nak Y,Sahin M,ozyigit o,Nak D Investigation of relationships between serum lactate, acute phase proteins, pro/ antiinflammatory cytokine levels, and metritis formation in Holstein dairy heifers. Turkish Journal of Veterinary and Animal Sciences. 2023; 47(3): 176 - 184. 10.55730/1300-0128.4284
Vancouver	Avcılar T,Koca D,Nak Y,Sahin M,ozyigit o,Nak D Investigation of relationships between serum lactate, acute phase proteins, pro/ antiinflammatory cytokine levels, and metritis formation in Holstein dairy heifers. Turkish Journal of Veterinary and Animal Sciences. 2023; 47(3): 176 - 184. 10.55730/1300-0128.4284
IEEE	Avcılar T,Koca D,Nak Y,Sahin M,ozyigit o,Nak D "Investigation of relationships between serum lactate, acute phase proteins, pro/ antiinflammatory cytokine levels, and metritis formation in Holstein dairy heifers." Turkish Journal of Veterinary and Animal Sciences, 47, ss.176 - 184, 2023. 10.55730/1300-0128.4284
ISNAD	Avcılar, Talha vd. "Investigation of relationships between serum lactate, acute phase proteins, pro/ antiinflammatory cytokine levels, and metritis formation in Holstein dairy heifers". Turkish Journal of Veterinary and Animal Sciences 47/3 (2023), 176-184. https://doi.org/10.55730/1300-0128.4284