Evaluation of Mechanical and Mucoadhesive Properties of Polyvinyl Alcohol Nanofibers As Vaginal Drug Delivery System
Yıl: 2023 Cilt: 48 Sayı: 2 Sayfa Aralığı: 219 - 230 Metin Dili: İngilizce DOI: 10.55262/fabadeczacilik.1268029 İndeks Tarihi: 17-08-2023
Evaluation of Mechanical and Mucoadhesive Properties of Polyvinyl Alcohol Nanofibers As Vaginal Drug Delivery System
Öz: Electrospinning is a versatile and inexpensive technique to produce nanofibers. Nanofibers can be an excellent alternative to classical dosage forms in vaginal applications due to high surface area/volume ratio, high encapsulation efficiency, and mucoadhesive properties. Polyvinyl alcohol (PVA) is a biocompatible, easily degradable, and flexible polymer with mucoadhesive properties used in industrial, commercial, and medical applications. The scope of this study is to characterize electrospun nanofibers produced with different PVA types for vaginal use. PVA nanofibers were produced using the electrospinning method. Nanofiber formulations were prepared by dissolving PVA in dimethylformamide (DMF): distilled water (1:1) solvent system. Nanofibers were produced with three different types of PVA at 5%, 7.5%, and 10% concentrations. The surface tension, viscosity, and conductivity properties of the polymer mixtures were measured for the electrospinning process and these parameters were found suitable for nanofiber production. While the viscosity increased with increasing polymer concentration, the surface tension values were found to be close to each other since the solvent system was the same. The mechanical and mucoadhesive properties of nanofibers were examined and compared. Mucoadhesive and mechanical properties of nanofiber formulations differed depending on molecular weight and electrospinning process. The nanofiber formulations produced with Polyviol 13/140 were found suitable for vaginal applications in terms of their mechanical and mucoadhesive properties. PVA nanofibers can be a good alternative as a drug delivery system in vaginal applications.
Anahtar Kelime: Vajinal İlaç Taşıyıcı Sistem Olarak Polivinil Alkol Nanoliflerinin Mekanik ve Mukoadezif Özelliklerinin Değerlendirilmesi
Öz: Elektroçekim, nanoliflerin üretilmesi için çok yönlü ve ucuz bir tekniktir. Nanolifler, yüksek yüzey alanı/hacim oranı, yüksek kapsülleme etkinliği ve mukoadezif özellikleri nedeniyle vajinal uygulamalarda klasik dozaj formlarına iyi bir alternatif olabilir. Polivinil alkol (PVA), endüstriyel, ticari ve tıbbi uygulamalarda kullanılan, biyouyumlu, kolay parçalanabilen ve mukoadezif özelliklere sahip esnek bir polimerdir. Bu çalışmanın kapsamı vajinal kullanım için farklı PVA tipleri ile üretilen elektropsun nanoliflerini karakterize etmektir. PVA nanolifleri, elektroeğirme yöntemi kullanılarak üretildi. Nanolif formülasyonları, PVA’nın dimetilformamid (DMF):saf su (1:1) solvent sisteminde çözülmesiyle hazırlandı. Nanolifler, %5, %7,5 ve %10 konsantrasyonlarında üç farklı tipte PVA ile üretilmiştir. Elektroçekim işlemi için polimer karışımlarının yüzey gerilimi, viskozite ve iletkenlik özellikleri ölçülmüş ve bu parametreler nanolif üretimi için uygun bulunmuştur. Artan polimer konsantrasyonu ile viskozite artarken, solvent sistemi aynı olduğu için yüzey gerilimi değerlerinin birbirine yakın olduğu görülmüştür. Nanoliflerin mekanik ve mukoadezif özellikleri incelenmiş ve karşılaştırılmıştır. Nanolif formülasyonlarının mukoadezif ve mekanik özellikleri moleküler ağırlık ve elektroeğirme işlemine bağlı olarak farklılık göstermiştir. Polyviol 13/140 ile üretilen nanolif formülasyonları, mekanik ve mukoadezif özellikleri açısından vajinal uygulamalar için uygun bulunmuştur. PVA nanolifleri, vajinal uygulamalarda ilaç taşıyıcı sistem olarak iyi bir alternatif olabilir.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | SAAR S, Tuğcu Demiröz F (2023). Evaluation of Mechanical and Mucoadhesive Properties of Polyvinyl Alcohol Nanofibers As Vaginal Drug Delivery System. , 219 - 230. 10.55262/fabadeczacilik.1268029 |
| Chicago | SAAR SINEM,Tuğcu Demiröz Fatma Nur Evaluation of Mechanical and Mucoadhesive Properties of Polyvinyl Alcohol Nanofibers As Vaginal Drug Delivery System. (2023): 219 - 230. 10.55262/fabadeczacilik.1268029 |
| MLA | SAAR SINEM,Tuğcu Demiröz Fatma Nur Evaluation of Mechanical and Mucoadhesive Properties of Polyvinyl Alcohol Nanofibers As Vaginal Drug Delivery System. , 2023, ss.219 - 230. 10.55262/fabadeczacilik.1268029 |
| AMA | SAAR S,Tuğcu Demiröz F Evaluation of Mechanical and Mucoadhesive Properties of Polyvinyl Alcohol Nanofibers As Vaginal Drug Delivery System. . 2023; 219 - 230. 10.55262/fabadeczacilik.1268029 |
| Vancouver | SAAR S,Tuğcu Demiröz F Evaluation of Mechanical and Mucoadhesive Properties of Polyvinyl Alcohol Nanofibers As Vaginal Drug Delivery System. . 2023; 219 - 230. 10.55262/fabadeczacilik.1268029 |
| IEEE | SAAR S,Tuğcu Demiröz F "Evaluation of Mechanical and Mucoadhesive Properties of Polyvinyl Alcohol Nanofibers As Vaginal Drug Delivery System." , ss.219 - 230, 2023. 10.55262/fabadeczacilik.1268029 |
| ISNAD | SAAR, SINEM - Tuğcu Demiröz, Fatma Nur. "Evaluation of Mechanical and Mucoadhesive Properties of Polyvinyl Alcohol Nanofibers As Vaginal Drug Delivery System". (2023), 219-230. https://doi.org/10.55262/fabadeczacilik.1268029 |
| APA | SAAR S, Tuğcu Demiröz F (2023). Evaluation of Mechanical and Mucoadhesive Properties of Polyvinyl Alcohol Nanofibers As Vaginal Drug Delivery System. FABAD Journal of Pharmaceutical Sciences, 48(2), 219 - 230. 10.55262/fabadeczacilik.1268029 |
| Chicago | SAAR SINEM,Tuğcu Demiröz Fatma Nur Evaluation of Mechanical and Mucoadhesive Properties of Polyvinyl Alcohol Nanofibers As Vaginal Drug Delivery System. FABAD Journal of Pharmaceutical Sciences 48, no.2 (2023): 219 - 230. 10.55262/fabadeczacilik.1268029 |
| MLA | SAAR SINEM,Tuğcu Demiröz Fatma Nur Evaluation of Mechanical and Mucoadhesive Properties of Polyvinyl Alcohol Nanofibers As Vaginal Drug Delivery System. FABAD Journal of Pharmaceutical Sciences, vol.48, no.2, 2023, ss.219 - 230. 10.55262/fabadeczacilik.1268029 |
| AMA | SAAR S,Tuğcu Demiröz F Evaluation of Mechanical and Mucoadhesive Properties of Polyvinyl Alcohol Nanofibers As Vaginal Drug Delivery System. FABAD Journal of Pharmaceutical Sciences. 2023; 48(2): 219 - 230. 10.55262/fabadeczacilik.1268029 |
| Vancouver | SAAR S,Tuğcu Demiröz F Evaluation of Mechanical and Mucoadhesive Properties of Polyvinyl Alcohol Nanofibers As Vaginal Drug Delivery System. FABAD Journal of Pharmaceutical Sciences. 2023; 48(2): 219 - 230. 10.55262/fabadeczacilik.1268029 |
| IEEE | SAAR S,Tuğcu Demiröz F "Evaluation of Mechanical and Mucoadhesive Properties of Polyvinyl Alcohol Nanofibers As Vaginal Drug Delivery System." FABAD Journal of Pharmaceutical Sciences, 48, ss.219 - 230, 2023. 10.55262/fabadeczacilik.1268029 |
| ISNAD | SAAR, SINEM - Tuğcu Demiröz, Fatma Nur. "Evaluation of Mechanical and Mucoadhesive Properties of Polyvinyl Alcohol Nanofibers As Vaginal Drug Delivery System". FABAD Journal of Pharmaceutical Sciences 48/2 (2023), 219-230. https://doi.org/10.55262/fabadeczacilik.1268029 |
