Yıl: 2023 Cilt: 14 Sayı: 2 Sayfa Aralığı: 274 - 279 Metin Dili: İngilizce DOI: 10.18663/tjcl.1236710 İndeks Tarihi: 22-08-2023

REAL-LIFE DATA OF PAZOPANIB USAGE IN SOFT TISSUE SARCOMA

Öz:
Abstract: Objective: Soft tissue sarcomas are heterogeneous group of malignancies consisting of more than 50 subtypes. Although it is rare, it is usually resistant to chemotherapy and has a poor prognosis. In this study, we planned to investigate the efficacy, tolerability and side-effect profile of pazopanib in metastatic soft tissue sarcomas. Method-Material: Our study was a single-center retrospective study and included metastatic patients over the age of 18 who were treated with pazopanib. Data of 37 patients were obtained in retrospective medical records. In patients using pazopanib; Tumor location, histological subtype, tumor grade, disease stage, the line at which pazopanib was used, efficacy, tolerability, and side-effect profile of pazopanib were examined. Findings: The mean age of the patients at diagnosis was 49. Pleomorphic sarcoma was the most common subtype. The progression-free survival (PFS) of patients after first-line therapy was 18 weeks. The median overall survival (OS) of the patients was 20 months. The median PFS with pazopanip was 18 weeks. Conclusion: In the study we conducted research in terms of effectiveness and side effects; the use of pazopanib in soft tissue sarcoma was found to be effective in terms of both PFS and OS. Side effects were tolerable and treatable. In our study, a PFS of 32 weeks was obtained in patients with hypothyroidism and at 16 weeks in patients who did not. In this respect, development of hypothyroidism may be a predictive parameter for response.
Anahtar Kelime: pazopanib hypothyroidism side effect sarcoma

YUMUŞAK DOKU SARKOMUNDA PAZOPANIB KULLANIMINA İLİŞKİN GERÇEK HAYAT VERİLERİ

Öz:
Özet Amaç: Yumuşak doku sarkomu 50 den fazla alt sınıftan oluşan heterojen bir malignite grubudur. Nadir görülmekle birlikte genellikle kemoterapiye dirençli olup, prognozu kötüdür. Çalışmamızda metastatik yumuşak doku sarkomlarında pazopanib kullanımının etkinliği, tolerabilitesi ve yan etki profilini araştırmayı planladık. Yöntem: Çalışmamız tek merkezli retrospektif bir çalışma olup, metastatik olan ve pazopanib alan 18 yaş üstü hastalar dahil edildi. Geriye yönelik dosya taramasında toplam 37 hastanın verisine ulaşıldı. Pazopanib kullanan hastalarda; tümörün yerleşim yeri, histolojik alt tipi, tümör derecesi, hastalığın evresi, pazopanibin hangi basamakta başlandığı, pazopanibin etkinliği, tolerabilitesi, ve yan etki profili incelendi. Bulgular: Hastaların tanı sırasında ortalama yaş 49. Pleomorfik sarkom en sık görülen alt tip idi. Birinci basamak tedavi sonrası hastaların progresyonsuz sağ kalımı (PFS) 18 hafta idi. Hastaların genel sağ kalım (OS) ortanca sağ kalım 20 ay bulundu. Pazopanib ile ortanca PFS 18 hafta olarak saptandı. Sonuç: Etkinlik ve yan etki yönünden araştırma yaptığımız çalışmada; yumuşak doku sarkomunda pazopanib kullanımı hem PFS hem OS açısından etkin bulundu. Yan etkiler tolere edilebilir ve tedavi edilebilir yan etkilerdi. Çalışmamızda hipotiroidi gelişen hastalarda 32 hafta, gelişmeyelerde ise 16 haftalık bir PFS elde edildi. Bu açıdan hipotiroidi gelişim yanıt için bir prediktif parametre olabilir.
Anahtar Kelime: pazopanib hipotiroidi yan etki sarkom

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA KARHAN O, İLERİ S, YERLİKAYA H, ÜRÜN M, SEZGİN Y (2023). REAL-LIFE DATA OF PAZOPANIB USAGE IN SOFT TISSUE SARCOMA. , 274 - 279. 10.18663/tjcl.1236710
Chicago KARHAN OĞUR,İLERİ Serdar,YERLİKAYA Halis,ÜRÜN Muslih,SEZGİN Yasin REAL-LIFE DATA OF PAZOPANIB USAGE IN SOFT TISSUE SARCOMA. (2023): 274 - 279. 10.18663/tjcl.1236710
MLA KARHAN OĞUR,İLERİ Serdar,YERLİKAYA Halis,ÜRÜN Muslih,SEZGİN Yasin REAL-LIFE DATA OF PAZOPANIB USAGE IN SOFT TISSUE SARCOMA. , 2023, ss.274 - 279. 10.18663/tjcl.1236710
AMA KARHAN O,İLERİ S,YERLİKAYA H,ÜRÜN M,SEZGİN Y REAL-LIFE DATA OF PAZOPANIB USAGE IN SOFT TISSUE SARCOMA. . 2023; 274 - 279. 10.18663/tjcl.1236710
Vancouver KARHAN O,İLERİ S,YERLİKAYA H,ÜRÜN M,SEZGİN Y REAL-LIFE DATA OF PAZOPANIB USAGE IN SOFT TISSUE SARCOMA. . 2023; 274 - 279. 10.18663/tjcl.1236710
IEEE KARHAN O,İLERİ S,YERLİKAYA H,ÜRÜN M,SEZGİN Y "REAL-LIFE DATA OF PAZOPANIB USAGE IN SOFT TISSUE SARCOMA." , ss.274 - 279, 2023. 10.18663/tjcl.1236710
ISNAD KARHAN, OĞUR vd. "REAL-LIFE DATA OF PAZOPANIB USAGE IN SOFT TISSUE SARCOMA". (2023), 274-279. https://doi.org/10.18663/tjcl.1236710
APA KARHAN O, İLERİ S, YERLİKAYA H, ÜRÜN M, SEZGİN Y (2023). REAL-LIFE DATA OF PAZOPANIB USAGE IN SOFT TISSUE SARCOMA. Turkish Journal of Clinics and Laboratory, 14(2), 274 - 279. 10.18663/tjcl.1236710
Chicago KARHAN OĞUR,İLERİ Serdar,YERLİKAYA Halis,ÜRÜN Muslih,SEZGİN Yasin REAL-LIFE DATA OF PAZOPANIB USAGE IN SOFT TISSUE SARCOMA. Turkish Journal of Clinics and Laboratory 14, no.2 (2023): 274 - 279. 10.18663/tjcl.1236710
MLA KARHAN OĞUR,İLERİ Serdar,YERLİKAYA Halis,ÜRÜN Muslih,SEZGİN Yasin REAL-LIFE DATA OF PAZOPANIB USAGE IN SOFT TISSUE SARCOMA. Turkish Journal of Clinics and Laboratory, vol.14, no.2, 2023, ss.274 - 279. 10.18663/tjcl.1236710
AMA KARHAN O,İLERİ S,YERLİKAYA H,ÜRÜN M,SEZGİN Y REAL-LIFE DATA OF PAZOPANIB USAGE IN SOFT TISSUE SARCOMA. Turkish Journal of Clinics and Laboratory. 2023; 14(2): 274 - 279. 10.18663/tjcl.1236710
Vancouver KARHAN O,İLERİ S,YERLİKAYA H,ÜRÜN M,SEZGİN Y REAL-LIFE DATA OF PAZOPANIB USAGE IN SOFT TISSUE SARCOMA. Turkish Journal of Clinics and Laboratory. 2023; 14(2): 274 - 279. 10.18663/tjcl.1236710
IEEE KARHAN O,İLERİ S,YERLİKAYA H,ÜRÜN M,SEZGİN Y "REAL-LIFE DATA OF PAZOPANIB USAGE IN SOFT TISSUE SARCOMA." Turkish Journal of Clinics and Laboratory, 14, ss.274 - 279, 2023. 10.18663/tjcl.1236710
ISNAD KARHAN, OĞUR vd. "REAL-LIFE DATA OF PAZOPANIB USAGE IN SOFT TISSUE SARCOMA". Turkish Journal of Clinics and Laboratory 14/2 (2023), 274-279. https://doi.org/10.18663/tjcl.1236710