INTRODUCTION: Radiation exposure during mechanical thrombectomy (MT) procedure in acute ischemic stroke patients with large vessel occlusion poses risks for both the patient and the neurointerventionalists. In this study, we evaluated the relationship between radiation dose and angiographic parameters in patients undergoing MT. METHODS: 101 patients who underwent mechanical thrombectomy between January 2022 and December 2022 were prospectively enrolled and retrospectively evaluated. Demographic data, degree of vessel recanalization, good (mRS 0-2) or poor (mRS 3-6) clinical outcome, angiographic procedure times, and radiation dose exposure during the procedure were recorded. RESULTS: The mean age was 69.9±13.4 years and the National Institutes of Health Stroke Scale (NIHSS) score at presentation was 15.2±5.1. The average time interval from groin puncture to occluded vessel recanalization was 25.1±15.2 minutes, the mean number of passes was 2.1±1.6, and the mean radiation dose was 878.6±555.6 milligrays. There was a significant, mild positive correlation between the number of passes and the radiation dose to which the patient was exposed (r: 0.196, p<0.05). There was a significant, moderate positive correlation between time to recanalization of the occluded vessel from groin puncture and the radiation dose to which the patient was exposed (r: 0.416, p<0.001). DISCUSSION AND CONCLUSION: Radiation dose exposure during stroke neurointervention is very important for both neurointerventionalists and patients. Optimum angiographic doses should be determined to obtain suffiecient image quality. First-pass effect and complete recanalization (mTICI3) should be targeted for not only to attain good clinical outcome (mRS 0-2) but also reduce patient exposure to radiation.