TY  - JOUR
TI  - Determination of Candidate Alternative Plant Actives for Dementia and Alzheimer’s  Disease Proteins through Docking Studies
AB  - Alzheimer's disease (AD) is a common type of dementia, which is a progressive brain disorder causing memory, thought and behavioral issues.  Effective therapeutic treatments for AD and/or Dementia have not yet been developed. In this study select transcriptomic datasets were analyzed and disease  proteins that comply with selection criteria were identified. These proteins were then docked with Donepezil, Galantamine, Memantine and Rivastigmine drugs as  well as Thymus cilicius, Melissa officinalis, Salvia sclarea, Linum usitatissimum and Curcuma longa plant actives. Resulting binding energy values for mutant proteins  are significantly different from wild type, especially in MET (MET proto-oncogene, receptor tyrosine kinase) (PDB ID: 3ZXZ). The plant actives showed notable Relative  Stability values when docked with wild type proteins in comparison to drug molecules. To conclude, Alpha-Muurolene, Alpha-Atlantone, Alpha-Cadinene, BetaBourbonene, Beta-Cubebene and Germacrene-D as candidate alternative plant actives have been suggested for these diseases.
AU  - Sevimoğlu, Tuba
AU  - enisoğlu atalay, vildan
AU  - Ozturk, Aysenur
DO  - 10.19113/sdufenbed.1213583
PY  - 2023
JO  - Süleyman Demirel Üniversitesi Fen Bilimleri Enstitüsü Dergisi
VL  - 27
IS  - 2
SN  - 1300-7688
SP  - 255
EP  - 265
DB  - TRDizin
UR  - http://search/yayin/detay/1193593
ER  -