Yıl: 2023 Cilt: 9 Sayı: 3 Sayfa Aralığı: 265 - 270 Metin Dili: İngilizce DOI: 10.53394/akd.1032104 İndeks Tarihi: 05-09-2023

The Value Of Ultra-Sensitive Troponin-I In Determining Mortality In Patients With Suspected Acute Coronary Syndrome

Öz:
Objective: This study investigated the role of the reference value of ultra-sensitive troponin kits used in daily practice in determining mortality. Material and Methods: This study was conducted in the emergency department (ED) of Akdeniz University Hospital between January 1 2018 and June 30 2019. All patients admitted to the emergency department within a period of eighteen months and who had the result of the ultra-sensitive troponin level in the range of 0.06-0.1 ng/mL were included in the study. The recurrent admissions of the patients to the ED were included, and only the first troponin values of the patients were taken as s reference for the study. Results: It was determined that 1029 troponin values of 591 patients with initial troponin I value in the range 0.06-0.1 ng/mL were measured. It was found that 332 of these patients were discharged from the emergency department, and the others were hospitalized. It was found that 168 (28.43%) of the patients died. Considering the gender distribution of the patients who died, it was observed that 101 (60.11%) patients were male, and 67 (39.89%) patients were female. A statistically significant difference was found between the ages of the patients who died (mean 71.38±12.25) and the age of patients alive (mean 61.78 ± 15.89) (p <0.019). In univariate analysis, in addition to the positive troponin value, DM (p<0.022) and hyperlipidemia (p<0.018) were found to be statistically significant. Conclusion: For high-sensitive troponin worked in the ED, the upper value of 0.06 ng/mL effectively determines mortality.
Anahtar Kelime: Ultra-Sensitive Troponin-I Mortality Acute coronary syndrome

Akut Koroner Sendrom Şüpheli Hastalarda Mortalitenin Belirlenmesinde Ultra-Duyarlı Troponin-I'in Değeri

Öz:
Amaç: Bu çalışmada, günlük pratikte kullanılan ultra-duyarlı troponin kitlerinin referans değerinin mortaliteyi belirlemedeki rolü araştırıldı. Gereç ve Yöntemler: Bu çalışma 1 Ocak 2018-30 Haziran 2019 tarihleri arasında Akdeniz Üniversitesi Hastanesi acil servisinde (AS) yapılmıştır. On sekiz ay içinde acil servise başvuran ve ultrasensitif troponin sonucu 0,06-0,1 ng/mL aralığında olan tüm hastalar çalışmaya dahil edildi. Hastaların acil servise tekrarlayan başvuruları dahil edildi ve hastaların sadece ilk troponin değerleri çalışma için referans olarak alındı. Bulgular: Başlangıç troponin I değeri 0,06-0,1 ng/mL aralığında olan 591 hastanın 1029 troponin değerinin ölçüldüğü belirlendi. Bu hastalardan 332'sinin acil servisten taburcu edildiği, diğerlerinin ise hastaneye kaldırıldığı öğrenildi. Hastaların 168'inin (%28,43) öldüğü belirlendi. Ölen hastaların cinsiyet dağılımına bakıldığında 101 (%60,11) hastanın erkek, 67 (%39,89) hastanın kadın olduğu görüldü. Ölen hastaların yaşları (ortalama 71,38±12,25) ile yaşayan hastaların yaşları (ortalama 61,78±15,89) arasında istatistiksel olarak anlamlı fark bulundu (p<0,019). Tek değişkenli analizde pozitif troponin değerine ek olarak DM (p<0,022) ve hiperlipidemi (p<0,018) istatistiksel olarak anlamlı bulundu. Sonuç: Acil serviste çalışılan yüksek duyarlı troponin için 0,06 ng/mL'lik üst değer etkin bir şekilde mortaliteyi belirler.
Anahtar Kelime: Ultra-Sensitive Troponin-I Mortalite Akut koroner sendrom

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
  • 1.Bingisser R, Cairns C, Christ M, Hausfater P, Lindahl B, Mair J, Panteghini M, Price C, Venge P. Cardiac troponin: a critical review of the case for point-of-care testing in the ED. Am J Emerg Med. 2012;30(8):1639-49.
  • 2.Christ M, Popp S, Pohlmann H, Poravas M, Umarov D, Bach R, Bertsch T. Implementation of high sensitivity cardiac troponin T measurement in the emergency department. Am J Med. 2010;123(12):1134-42.
  • 3.Pope JH, Aufderheide TP, Ruthazer R, Woolard RH, Feldman JA, Beshansky JR, Griffith JL, Selker HP. Missed diagnoses of acute cardiac ischemia in the emergency department. N Engl J Med. 2000;342(16):1163-70.
  • 4.Alpert JS, Thygesen K, Antman E, Bassand JP. Myocardial infarction redefined--a consensus document of The Joint European Society of Cardiology/ American College of Cardiology Committee for the redefinition of myocardial infarction. J Am Coll Cardiol. 2000;36(3):959-69.
  • 5.Apple FS, Collinson PO; IFCC Task Force on Clinical Applications of Cardiac Biomarkers. Analytical characteristics of high-sensitivity cardiac troponin assays. Clin Chem. 2012;58(1):54-61.
  • 6.Reichlin T, Hochholzer W, Bassetti S, Steuer S, Stelzig C, Hartwiger S, Biedert S, Schaub N, Buerge C, Potocki M, Noveanu M, Breidthardt T, Twerenbold R, Winkler K, Bingisser R, Mueller C. Early diagnosis of myocardial infarction with sensitive cardiac troponin assays. N Engl J Med. 2009;361(9):858-67.
  • 7.Kavasoglu ME, Eken C, Eray O, Serinken M, Gulen B. Value of High-Sensitive Cardiac Troponin in Predicting Mortality in the Emergency Department. Clinical Laboratory. 2016;62(8):1483-9.
  • 8.Lippi G, Sanchis-Gomar F. " Ultra-sensitive " cardiac troponins: Requirements for effective implementation in clinical practice. Biochem Med ( Zagreb ) 2018; 28: 030501.
  • 9.Nowak RM, Christenson RH, Jacobsen G, McCord J, Apple FS, Singer AJ, Limkakeng A Jr, Peacock WF, Defilippi CR. Performance of Novel High-Sensitivity Cardiac Troponin I Assays for 0/1-Hour and 0/2- to 3-Hour Evaluations for Acute Myocardial Infarction: Results From the HIGH-US Study. Ann Emerg Med. 2020;76(1):1-13.
  • 10.Reaney PDW, Elliott HI, Noman A, Cooper JG. Risk stratifying chest pain patients in the emergency department using HEART, GRACE, and TIMI scores, with a single contemporary troponin result, to predict major adverse cardiac events. Emerg Med J. 2018;35(7):420-7.
  • 11.Amsterdam EA, Wenger NK, Brindis RG, Casey DE Jr, Ganiats TG, Holmes DR Jr, Jaffe AS, Jneid H, Kelly RF, Kontos MC, Levine GN, Liebson PR, Mukherjee D, Peterson ED, Sabatine MS, Smalling RW, Zieman SJ. 2014 AHA/ACC Guideline for the Management of Patients with Non-ST-Elevation Acute Coronary Syndromes: a report of the American College of Cardiology/ American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol. 2014;64(24):e139-e228.
  • 12.Poldervaart JM, Langedijk M, Backus BE, Dekker IMC, Six AJ, Doevendans PA, Hoes AW, Reitsma JB. Comparison of the GRACE, HEART and TIMI score to predict major adverse cardiac events in chest pain patients at the emergency department. Int J Cardiol. 2017;227:656-61.
  • 13.Huang D, Refaat M, Mohammedi K, Jayyousi A, Al Suwaidi J, Abi Khalil C. Macrovascular Complications in Patients with Diabetes and Prediabetes. Biomed Res Int. 2017;2017:7839101.
  • 14.Chapman AR, Hesse K, Andrews J, Lee KK, Anand A, Shah ASV, Sandeman D, Ferry AV, Jameson J, Piya S, Stewart S, Marshall L, Strachan FE, Gray A, Newby DE, Mills NL. High-Sensitivity Cardiac Troponin I and Clinical Risk Scores in Patients With Suspected Acute Coronary Syndrome. Circulation. 2018;138(16):1654-65.
APA Aracı Ç, DUYAN M, KARTAL M, Göksu E (2023). The Value Of Ultra-Sensitive Troponin-I In Determining Mortality In Patients With Suspected Acute Coronary Syndrome. , 265 - 270. 10.53394/akd.1032104
Chicago Aracı Çeral Efe,DUYAN Murat,KARTAL MUTLU,Göksu Erkan The Value Of Ultra-Sensitive Troponin-I In Determining Mortality In Patients With Suspected Acute Coronary Syndrome. (2023): 265 - 270. 10.53394/akd.1032104
MLA Aracı Çeral Efe,DUYAN Murat,KARTAL MUTLU,Göksu Erkan The Value Of Ultra-Sensitive Troponin-I In Determining Mortality In Patients With Suspected Acute Coronary Syndrome. , 2023, ss.265 - 270. 10.53394/akd.1032104
AMA Aracı Ç,DUYAN M,KARTAL M,Göksu E The Value Of Ultra-Sensitive Troponin-I In Determining Mortality In Patients With Suspected Acute Coronary Syndrome. . 2023; 265 - 270. 10.53394/akd.1032104
Vancouver Aracı Ç,DUYAN M,KARTAL M,Göksu E The Value Of Ultra-Sensitive Troponin-I In Determining Mortality In Patients With Suspected Acute Coronary Syndrome. . 2023; 265 - 270. 10.53394/akd.1032104
IEEE Aracı Ç,DUYAN M,KARTAL M,Göksu E "The Value Of Ultra-Sensitive Troponin-I In Determining Mortality In Patients With Suspected Acute Coronary Syndrome." , ss.265 - 270, 2023. 10.53394/akd.1032104
ISNAD Aracı, Çeral Efe vd. "The Value Of Ultra-Sensitive Troponin-I In Determining Mortality In Patients With Suspected Acute Coronary Syndrome". (2023), 265-270. https://doi.org/10.53394/akd.1032104
APA Aracı Ç, DUYAN M, KARTAL M, Göksu E (2023). The Value Of Ultra-Sensitive Troponin-I In Determining Mortality In Patients With Suspected Acute Coronary Syndrome. Akdeniz Tıp Dergisi, 9(3), 265 - 270. 10.53394/akd.1032104
Chicago Aracı Çeral Efe,DUYAN Murat,KARTAL MUTLU,Göksu Erkan The Value Of Ultra-Sensitive Troponin-I In Determining Mortality In Patients With Suspected Acute Coronary Syndrome. Akdeniz Tıp Dergisi 9, no.3 (2023): 265 - 270. 10.53394/akd.1032104
MLA Aracı Çeral Efe,DUYAN Murat,KARTAL MUTLU,Göksu Erkan The Value Of Ultra-Sensitive Troponin-I In Determining Mortality In Patients With Suspected Acute Coronary Syndrome. Akdeniz Tıp Dergisi, vol.9, no.3, 2023, ss.265 - 270. 10.53394/akd.1032104
AMA Aracı Ç,DUYAN M,KARTAL M,Göksu E The Value Of Ultra-Sensitive Troponin-I In Determining Mortality In Patients With Suspected Acute Coronary Syndrome. Akdeniz Tıp Dergisi. 2023; 9(3): 265 - 270. 10.53394/akd.1032104
Vancouver Aracı Ç,DUYAN M,KARTAL M,Göksu E The Value Of Ultra-Sensitive Troponin-I In Determining Mortality In Patients With Suspected Acute Coronary Syndrome. Akdeniz Tıp Dergisi. 2023; 9(3): 265 - 270. 10.53394/akd.1032104
IEEE Aracı Ç,DUYAN M,KARTAL M,Göksu E "The Value Of Ultra-Sensitive Troponin-I In Determining Mortality In Patients With Suspected Acute Coronary Syndrome." Akdeniz Tıp Dergisi, 9, ss.265 - 270, 2023. 10.53394/akd.1032104
ISNAD Aracı, Çeral Efe vd. "The Value Of Ultra-Sensitive Troponin-I In Determining Mortality In Patients With Suspected Acute Coronary Syndrome". Akdeniz Tıp Dergisi 9/3 (2023), 265-270. https://doi.org/10.53394/akd.1032104