ABSTRACT Objective: Modern burn care is dependent on the effective management of burn pain. Although opioids remain the cornerstone of treatment, their adverse effects remain serious. In this study, we investigated non-opioid painkillers, including acetaminophen and dexketoprofen, which are commonly used in the clinical practice for adult burn inpatients who do not require admission to an intensive care unit. Methods: Thirteen consecutive inpatients with burns were included in this study. During the six-day period, the patients self-administered painkillers as needed. The time of medication intake was recorded, and a visual analog scale was used to assess pain. Thereafter, statistical analyses were performed. Results: No significant differences were observed between age and sex groups. As the percentage of burns increased, the number of painkillers used also increased. It was found that the patients took painkillers most frequently at 11 o'clock (when the wound dressing was changed) and least frequently at 14 o'clock. No significant difference was observed between the effects of dexketoprofen and paracetamol in reducing pain. Conclusions: The need for painkillers in patients with burns varies throughout the day. The effectiveness of acetaminophen and dexketoprofen during the day was higher than that during dressing changes. The total body surface area should be considered with regards to the amount and frequency of painkiller administered.