Evaluation of the Effect of Ferula Rigidula Extract on Sperm Parameters, Antioxidant Parameters and Testicular Structure in Male Rats in Experimental Diabetic Condition

Saadet BELHAN, (Van Yüzüncü Yıl Üniversitesi, Veteriner Fakültesi, Döllenme ve Suni Tohumlama Anabilim Dalı, 65080, Van, Türkiye)
Salih ÇİBUK, (Van Yüzüncü Yıl Üniversitesi, Sağlık Hizmetleri Meslek Yüksekokulu, 65080, Van, Türkiye)
Ahmet Ufuk KÖMÜROĞLU, (Van Yüzüncü Yıl Üniversitesi, Sağlık Hizmetleri Meslek Yüksekokulu, 65080, Van, Türkiye)
Fikret ALTINDAĞ, (Van Yüzüncü Yıl Üniversitesi, Tıp Fakültesi, Histoloji ve Embriyoloji Anabilim Dalı, 65080, Van, Türkiye)
Yeter DEĞER (Van Yüzüncü Yıl Üniversitesi, Veteriner Fakültesi, Biyokimya Anabilim Dalı, 65080, Van, Türkiye)
Van Veterinary Journal
3 0
Yıl: 2023 Cilt: 34 Sayı: 2 Sayfa Aralığı: 119 - 125 Metin Dili: İngilizce DOI: 10.36483/vanvetj.1255832 İndeks Tarihi: 14-09-2023

Evaluation of the Effect of Ferula Rigidula Extract on Sperm Parameters, Antioxidant Parameters and Testicular Structure in Male Rats in Experimental Diabetic Condition

Öz:
The study was conducted to investigate how Ferula rigidula extract affected sperm profile, antioxidant parameters, and stereological profile in experimental diabetic rats. Performed on forty-nine male rats. The rats were randomly assigned to control group, diabetic group, diabetic + Ferula rigidula group 1, diabetic + Ferula rigidula group 2, diabetic + glibenclamide group, Ferula rigidula group 1, and Ferula rigidula group 2. While sperm count, motility, antioxidant parameters, testosterone hormone, germinal epithelial volume, and germinal epithelial height decreased in the diabetic group, abnormal sperm count, malondialdehyde level, and lumen volume increased. When Ferula rigidula (extract) was given to diabetic rats, it brought the stereological findings to the same level as the control group. In addition, it was determined that there were improvements in biochemical parameters, approaching the values of the control group. Specifically, when Ferula rigidula extract was administered alone, testosterone levels and stereological findings improved in group 1. In addition, it was determined that there were significant improvements in sperm parameters. However, it was determined that the positive effect of Ferula rigidula extract was very significant at low doses (250 mg/kg) and decreased at high doses (500 mg/kg). As a result, Ferula rigidula extract has an antioxidant role and can be used to alleviate the problems caused by diabetes in the male reproductive system.
Anahtar Kelime: Diabetes Ferula Rat Sperm

Deneysel Diyabetik Durumda Erkek Sıçanlarda Ferula Rigidula Ekstraktının Sperm Parametreleri, Antioksidan Parametreler ve Testis Yapısı Üzerine Etkisinin Değerlendirilmesi

Öz:
Çalışma, deneysel diyabetik sıçanlarda Ferula rigidula ekstraktının sperm profilini, antioksidan parametreleri ve stereolojik profili nasıl etkilediğini araştırmak için yapıldı. Kırk dokuz erkek sıçan üzerinde gerçekleştirildi. Sıçanlar kontrol grubu, diyabetik grup, diyabetik + Ferula rigidula grup 1, diyabetik + Ferula rigidula grup 2, Diyabetik + glibenklamid grubu, Ferula rigidula grup 1 ve Ferula rigidula grup 2 olarak rastgele ayrıldı. Diyabetik grupta sperm sayısı, motilite, antioksidan parametreler, testosteron hormonu, germinal epitel hacmi ve germinal epitel yüksekliği azalırken, anormal sperm sayısı, malondialdehit düzeyi ve lümen hacmi arttı. Diyabetik ratlara Ferula rigidula (ekstrakt) verildiğinde stereolojik bulguları kontrol grubu ile aynı düzeye getirdi. Ayrıca biyokimyasal parametrelerde kontrol grubu değerlerine yaklaşacak şekilde iyileşmelerin olduğu tespit edildi. Özellikle, Ferula rigidula ekstresi tek başına uygulandığında, 1. grupta testosteron düzeylerinde ve stereolojik bulgularda iyileşme oldu. Bunun yanı sıra sperm parametrelerinde anlamlı olarak düzelmelerin olduğu belirlendi. Ancak, Ferula rigidula ekstraktının olumlu etkisinin düşük dozda (250 mg/kg) çok belirgin olduğu, yüksek dozlarda (500 mg/kg) ise azaldığı tespit edildi. Sonuç olarak, Ferula rigidula ekstresi antioksidan role sahiptir ve erkek üreme sisteminde diyabetin neden olduğu sorunları hafifletmek için kullanılabilir.
Anahtar Kelime: Diyabet Ferula Sıçan Sperm

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA Belhan S, ÇIBUK S, kömüroğlu a, altındağ f, DEĞER Y (2023). Evaluation of the Effect of Ferula Rigidula Extract on Sperm Parameters, Antioxidant Parameters and Testicular Structure in Male Rats in Experimental Diabetic Condition. , 119 - 125. 10.36483/vanvetj.1255832
Chicago Belhan Saadet,ÇIBUK SALIH,kömüroğlu ahmet ufuk,altındağ fikret,DEĞER YETER Evaluation of the Effect of Ferula Rigidula Extract on Sperm Parameters, Antioxidant Parameters and Testicular Structure in Male Rats in Experimental Diabetic Condition. (2023): 119 - 125. 10.36483/vanvetj.1255832
MLA Belhan Saadet,ÇIBUK SALIH,kömüroğlu ahmet ufuk,altındağ fikret,DEĞER YETER Evaluation of the Effect of Ferula Rigidula Extract on Sperm Parameters, Antioxidant Parameters and Testicular Structure in Male Rats in Experimental Diabetic Condition. , 2023, ss.119 - 125. 10.36483/vanvetj.1255832
AMA Belhan S,ÇIBUK S,kömüroğlu a,altındağ f,DEĞER Y Evaluation of the Effect of Ferula Rigidula Extract on Sperm Parameters, Antioxidant Parameters and Testicular Structure in Male Rats in Experimental Diabetic Condition. . 2023; 119 - 125. 10.36483/vanvetj.1255832
Vancouver Belhan S,ÇIBUK S,kömüroğlu a,altındağ f,DEĞER Y Evaluation of the Effect of Ferula Rigidula Extract on Sperm Parameters, Antioxidant Parameters and Testicular Structure in Male Rats in Experimental Diabetic Condition. . 2023; 119 - 125. 10.36483/vanvetj.1255832
IEEE Belhan S,ÇIBUK S,kömüroğlu a,altındağ f,DEĞER Y "Evaluation of the Effect of Ferula Rigidula Extract on Sperm Parameters, Antioxidant Parameters and Testicular Structure in Male Rats in Experimental Diabetic Condition." , ss.119 - 125, 2023. 10.36483/vanvetj.1255832
ISNAD Belhan, Saadet vd. "Evaluation of the Effect of Ferula Rigidula Extract on Sperm Parameters, Antioxidant Parameters and Testicular Structure in Male Rats in Experimental Diabetic Condition". (2023), 119-125. https://doi.org/10.36483/vanvetj.1255832
APA Belhan S, ÇIBUK S, kömüroğlu a, altındağ f, DEĞER Y (2023). Evaluation of the Effect of Ferula Rigidula Extract on Sperm Parameters, Antioxidant Parameters and Testicular Structure in Male Rats in Experimental Diabetic Condition. Van Veterinary Journal, 34(2), 119 - 125. 10.36483/vanvetj.1255832
Chicago Belhan Saadet,ÇIBUK SALIH,kömüroğlu ahmet ufuk,altındağ fikret,DEĞER YETER Evaluation of the Effect of Ferula Rigidula Extract on Sperm Parameters, Antioxidant Parameters and Testicular Structure in Male Rats in Experimental Diabetic Condition. Van Veterinary Journal 34, no.2 (2023): 119 - 125. 10.36483/vanvetj.1255832
MLA Belhan Saadet,ÇIBUK SALIH,kömüroğlu ahmet ufuk,altındağ fikret,DEĞER YETER Evaluation of the Effect of Ferula Rigidula Extract on Sperm Parameters, Antioxidant Parameters and Testicular Structure in Male Rats in Experimental Diabetic Condition. Van Veterinary Journal, vol.34, no.2, 2023, ss.119 - 125. 10.36483/vanvetj.1255832
AMA Belhan S,ÇIBUK S,kömüroğlu a,altındağ f,DEĞER Y Evaluation of the Effect of Ferula Rigidula Extract on Sperm Parameters, Antioxidant Parameters and Testicular Structure in Male Rats in Experimental Diabetic Condition. Van Veterinary Journal. 2023; 34(2): 119 - 125. 10.36483/vanvetj.1255832
Vancouver Belhan S,ÇIBUK S,kömüroğlu a,altındağ f,DEĞER Y Evaluation of the Effect of Ferula Rigidula Extract on Sperm Parameters, Antioxidant Parameters and Testicular Structure in Male Rats in Experimental Diabetic Condition. Van Veterinary Journal. 2023; 34(2): 119 - 125. 10.36483/vanvetj.1255832
IEEE Belhan S,ÇIBUK S,kömüroğlu a,altındağ f,DEĞER Y "Evaluation of the Effect of Ferula Rigidula Extract on Sperm Parameters, Antioxidant Parameters and Testicular Structure in Male Rats in Experimental Diabetic Condition." Van Veterinary Journal, 34, ss.119 - 125, 2023. 10.36483/vanvetj.1255832
ISNAD Belhan, Saadet vd. "Evaluation of the Effect of Ferula Rigidula Extract on Sperm Parameters, Antioxidant Parameters and Testicular Structure in Male Rats in Experimental Diabetic Condition". Van Veterinary Journal 34/2 (2023), 119-125. https://doi.org/10.36483/vanvetj.1255832
Sayfa Oluşturulma Tarihi
24-04-2024 9:6

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