Evaluation of the genotoxic effect of nonylphenol applied in different doses on the bone marrow

YAY, ARZU HANIM; Bitgen, Nazmiye; Göktepe, Özge; BARAN, MÜNEVVER; İpek, Eren Kaan

doi:10.32571/ijct.1186924

Evaluation of the genotoxic effect of nonylphenol applied in different doses on the bone marrow

Nazmiye BITGEN, (Erciyes Üniversitesi, Tıp Fakültesi, Tıbbi Biyoloji Anabilim Dalı, Kayseri, Türkiye)

Ozge GOKTEPE, (Erciyes Üniversitesi, Tıp Fakültesi, Histoloji ve Embriyoloji Anabilim Dalı, 38039, Kayseri, Türkiye)

Munevver BARAN, (Erciyes Üniversitesi, Eczacılık Fakültesi, Farmasötik Temel Bilimler Anabilim Dalı, Kayseri, Türkiye)

Eren Kaan IPEK, (Erciyes Üniversitesi, Tıp Fakültesi, Tıbbi Biyoloji Anabilim Dalı, Kayseri, Türkiye)

Arzu YAY (Erciyes Üniversitesi, Tıp Fakültesi, Histoloji ve Embriyoloji Anabilim Dalı, 38039, Kayseri, Türkiye)

International Journal of Chemistry and Technology (IJCT)

2 0

Yıl: 2023 Cilt: 7 Sayı: 1 Sayfa Aralığı: 108 - 112 Metin Dili: İngilizce DOI: 10.32571/ijct.1186924 İndeks Tarihi: 25-09-2023

Evaluation of the genotoxic effect of nonylphenol applied in different doses on the bone marrow

Öz:

Nonylphenols are endocrine disrupting toxic compounds and are widely used. For this reason, our study aimed to investigate the genotoxic effect of nonylphenols applied at different doses on mouse bone marrow cells. Groups were classified as control group, the sham administered only group, low dose, medium dose and high dose nonylphenol administered group. After euthanasia, polychromatic erythrocyte/Normochromatic erythrocyte ratio and micronuclear polychromatic erythrocyte count were determined in femur bone marrow cells and analyzed to detect DNA damage. While polychromatic erythrocyte/Normochromatic erythrocyte ratio was found to be lower in the groups treated with different doses of nonylphenol, especially in the group treated with high-dose nonylphenol, this decrease was not statistically significant. When the micronucleated polychromatic erythrocyte values were examined, it was observed that there was a statistically significant increase, especially in the medium and high dose groups compared to the control. High-dose nonylphenol has a toxic effect and may have a long-term genotoxic effect such as cancer development by interacting with genotoxic agents.

Anahtar Kelime: Nonylphenol genotoxicity micronucleus.

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Bitgen N, Göktepe Ö, BARAN M, İpek E, YAY A (2023). Evaluation of the genotoxic effect of nonylphenol applied in different doses on the bone marrow. , 108 - 112. 10.32571/ijct.1186924
Chicago	Bitgen Nazmiye,Göktepe Özge,BARAN MÜNEVVER,İpek Eren Kaan,YAY ARZU HANIM Evaluation of the genotoxic effect of nonylphenol applied in different doses on the bone marrow. (2023): 108 - 112. 10.32571/ijct.1186924
MLA	Bitgen Nazmiye,Göktepe Özge,BARAN MÜNEVVER,İpek Eren Kaan,YAY ARZU HANIM Evaluation of the genotoxic effect of nonylphenol applied in different doses on the bone marrow. , 2023, ss.108 - 112. 10.32571/ijct.1186924
AMA	Bitgen N,Göktepe Ö,BARAN M,İpek E,YAY A Evaluation of the genotoxic effect of nonylphenol applied in different doses on the bone marrow. . 2023; 108 - 112. 10.32571/ijct.1186924
Vancouver	Bitgen N,Göktepe Ö,BARAN M,İpek E,YAY A Evaluation of the genotoxic effect of nonylphenol applied in different doses on the bone marrow. . 2023; 108 - 112. 10.32571/ijct.1186924
IEEE	Bitgen N,Göktepe Ö,BARAN M,İpek E,YAY A "Evaluation of the genotoxic effect of nonylphenol applied in different doses on the bone marrow." , ss.108 - 112, 2023. 10.32571/ijct.1186924
ISNAD	Bitgen, Nazmiye vd. "Evaluation of the genotoxic effect of nonylphenol applied in different doses on the bone marrow". (2023), 108-112. https://doi.org/10.32571/ijct.1186924

APA	Bitgen N, Göktepe Ö, BARAN M, İpek E, YAY A (2023). Evaluation of the genotoxic effect of nonylphenol applied in different doses on the bone marrow. International Journal of Chemistry and Technology (IJCT), 7(1), 108 - 112. 10.32571/ijct.1186924
Chicago	Bitgen Nazmiye,Göktepe Özge,BARAN MÜNEVVER,İpek Eren Kaan,YAY ARZU HANIM Evaluation of the genotoxic effect of nonylphenol applied in different doses on the bone marrow. International Journal of Chemistry and Technology (IJCT) 7, no.1 (2023): 108 - 112. 10.32571/ijct.1186924
MLA	Bitgen Nazmiye,Göktepe Özge,BARAN MÜNEVVER,İpek Eren Kaan,YAY ARZU HANIM Evaluation of the genotoxic effect of nonylphenol applied in different doses on the bone marrow. International Journal of Chemistry and Technology (IJCT), vol.7, no.1, 2023, ss.108 - 112. 10.32571/ijct.1186924
AMA	Bitgen N,Göktepe Ö,BARAN M,İpek E,YAY A Evaluation of the genotoxic effect of nonylphenol applied in different doses on the bone marrow. International Journal of Chemistry and Technology (IJCT). 2023; 7(1): 108 - 112. 10.32571/ijct.1186924
Vancouver	Bitgen N,Göktepe Ö,BARAN M,İpek E,YAY A Evaluation of the genotoxic effect of nonylphenol applied in different doses on the bone marrow. International Journal of Chemistry and Technology (IJCT). 2023; 7(1): 108 - 112. 10.32571/ijct.1186924
IEEE	Bitgen N,Göktepe Ö,BARAN M,İpek E,YAY A "Evaluation of the genotoxic effect of nonylphenol applied in different doses on the bone marrow." International Journal of Chemistry and Technology (IJCT), 7, ss.108 - 112, 2023. 10.32571/ijct.1186924
ISNAD	Bitgen, Nazmiye vd. "Evaluation of the genotoxic effect of nonylphenol applied in different doses on the bone marrow". International Journal of Chemistry and Technology (IJCT) 7/1 (2023), 108-112. https://doi.org/10.32571/ijct.1186924