TY  - JOUR
TI  - Evaluation of the genotoxic effect of nonylphenol applied in different doses on the bone marrow
AB  - Nonylphenols are endocrine disrupting toxic compounds and are widely used. For this reason, our study aimed to investigate the genotoxic effect of nonylphenols applied at different doses on mouse bone marrow cells. Groups were classified as control group, the sham administered only group, low dose, medium dose and high dose nonylphenol administered group. After euthanasia, polychromatic erythrocyte/Normochromatic erythrocyte ratio and micronuclear polychromatic erythrocyte count were determined in femur bone marrow cells and analyzed to detect DNA damage. While polychromatic erythrocyte/Normochromatic erythrocyte ratio was found to be lower in the groups treated with different doses of nonylphenol, especially in the group treated with high-dose nonylphenol, this decrease was not statistically significant. When the micronucleated polychromatic erythrocyte values were examined, it was observed that there was a statistically significant increase, especially in the medium and high dose groups compared to the control. High-dose nonylphenol has a toxic effect and may have a long-term genotoxic effect such as cancer development by interacting with genotoxic agents.
AU  - YAY, ARZU HANIM
AU  - Bitgen, Nazmiye
AU  - Göktepe, Özge
AU  - BARAN, MÜNEVVER
AU  - İpek, Eren Kaan
DO  - 10.32571/ijct.1186924
PY  - 2023
JO  - International Journal of Chemistry and Technology (IJCT)
VL  - 7
IS  - 1
SN  - 2602-277X
SP  - 108
EP  - 112
DB  - TRDizin
UR  - http://search/yayin/detay/1196091
ER  -