TY  - JOUR
TI  - Fatal thrombotic microangiopathy in an infant with COVID-19: a case report
AB  - Background. While macrovascular thrombosis is common in adult COVID-19 patients, thrombotic microangiopathy as a part of endothelitis might play an important role in severe organ dysfunction. Thrombocytopenia-associated multiple organ failure (TAMOF) is a thrombotic microangiopathy syndrome that is associated with endothelial damage. Herein, we aim to report a pediatric TAMOF case related to SARS-CoV-2 infection which has been scarcely reported to date. Case. A 7-month-old boy who became severely ill after being infected with SARS-CoV-2 required advanced critical care treatments such as continuous renal replacement therapy, therapeutic plasma exchange, and extracorporeal membrane oxygenation. A heart and lung biopsy obtained during sternotomy showed thrombotic microangiopathy. Despite early plasma exchange, mortality was inevitable because of severe liver failure. Conclusions. This case report implies that SARS-CoV-2 infection could cause TAMOF in children. To the best of our knowledge, this is the second SARS-CoV-2-induced pediatric TAMOF case. More studies are needed to determine alternative treatments for patients with TAMOF who are resistant to conventional therapies.
AU  - Sarıtaş Nakip, Özlem
AU  - Kesici, Selman
AU  - Terzi, Kıvanç
AU  - Orhan, Diclehan
AU  - BAYRAKCI, BENAN
DO  - 10.24953/turkjped.2022.1150
PY  - 2023
JO  - Turkish Journal of Pediatrics
VL  - 65
IS  - 4
SN  - 0041-4301
SP  - 667
EP  - 671
DB  - TRDizin
UR  - http://search/yayin/detay/1196183
ER  -