TY  - JOUR
TI  - Hyponatremia: More than just an electrolyte for COVID-19 patients
AB  - Aim: Hyponatremia is the most common electrolyte disturbance among infections, especially with pneumonia. Here, we aimed to analyze the presence of hyponatremia among COVID-19 patients along with its relation to the in- hospital mortality. Materials and methods: The patients were divided into two groups COVID-19 negative and positive and also with and without pneumonia. The association between hyponatremia and in-hospital mortality from any cause was evaluated with univariate and multivariate cox regression model. Results: A total of 636 patients, a mean age of 50± 18 years, 48 % of the female with a median duration of hospitalization of 5.5 (IQR, 2,11) days were included. Of those 553 (87%) were detected COVID-19 PCR positive and 298 (47%) of those with pneumonia. The median serum sodium concentration was lower in COVID-19 PCR positive patients [134 (IQR, 130,137) mEq/L] compared to negatives [139 (IQR, 136, 140) mEq/L] (p<0.001). The median serum sodium levels were significantly lower in patients with pneumonia [136 (IQR, 133.138) mEq/L] than without pneumonia [139 (IQR, 137, 145) mEq/L] (p<0.001). All deaths occurred in patients with pneumonia [(n=40 (13.4%)]. Hyponatremia was significantly associated with in-hospital mortality on unadjusted (OR, 3.85, 95%CI: 1.73, 8.53, P<0.001) and adjusted [OR, 3.58, 95% CI: 1.58, 8.1, P=0.002] Cox models. Conclusion: Hyponatremia at admission is prevalent and an independent risk factor for in-hospital mortality among COVID-19 patients particularly those with pneumonia. It might be an important laboratory clue for these patients’ diagnosis and survivals.
AU  - YAŞAR, Emre
AU  - ÖZGER, Hasan Selçuk
AU  - AYSERT YILDIZ, Pınar
AU  - BOZTEPE, Ulver
AU  - Deger, Serpil Muge
DO  - 10.18614/detip.1218114
PY  - 2023
JO  - Dokuz Eylül Üniversitesi Tıp Fakültesi Dergisi
VL  - 37
IS  - 2
SN  - 1300-6622
SP  - 97
EP  - 109
DB  - TRDizin
UR  - http://search/yayin/detay/1196466
ER  -