Yıl: 2023 Cilt: 62 Sayı: 3 Sayfa Aralığı: 473 - 476 Metin Dili: İngilizce İndeks Tarihi: 21-09-2023

Acute phase reaction with zoledronic acid infusion mimicking COVID-19

Öz:
During the pandemic, symptoms of many diseases that can be confused with the symptoms of COVID-19 have been detected and reported. In this case report, we reported a patient who showed flu-like symptoms and sudden lymphopenia within two days of zoledronic acid infusion. A 40-year-old female patient with a COVID-19 history was admitted to our hospital with abdominal pain. Hypercalcemia due to parathyroid adenoma was detected. Zoledronic acid (5 mg) was given intravenously for the treatment of hypercalcemia. Following the infusion; fever, C-Reactive Protein (CRP) increase and lymphopenia were detected in the patient. There were no apparent causes to explain these symptoms. The side effects we detected in the patient were confusingly similar to the symptoms of COVID-19. Repeated PCR tests and CT results indicated that the patient did not have COVID-19. A week later, the patient’s symptoms improved and the laboratory findings along with the physical examination returned to normal. The patient's condition was considered to be due to zoledronic acid infusion. We would like to draw attention to the acute phase reaction after zoledronic acid infusion in the COVID-19 era in which the clinical situation could be confusing.
Anahtar Kelime: Zoledronic acid COVID-19 flu-like symptoms lymphopenia

Zoledronik asit infüzyonu sonrası COVİD-19’u taklit eden akut faz reaksiyonu

Öz:
Pandemi süresince, COVID-19 semptomlarıyla karıştırılan birçok hastalık tespit edilmiş ve bildirilmiştir. Bu vaka sunumunda, zoledronik asit infüzyonundan sonraki iki gün içerisinde grip benzeri semptomlar ve akut lenfopeni gösteren bir hastayı sunduk. Geçirilmiş COVID-19 öyküsü olan, 40 yaş kadın hasta, abdominal ağrıyla tarafımıza başvurdu. Paratiroid adenomuna bağlı hiperkalsemi saptandı. Hiperkalsemi tedavisi için IV Zoledronik asit (5mg) verildi. İnfüzyonu takiben hastada ateş, C Reaktif Protein yüksekliğinde artış ve lenfopeni tespit edildi. Hastada bu bulguları açıklayabilecek herhangi bir sebep bulunamamıştır. Hastada tespit ettiğimiz yan etkiler, kafa karıştırıcı bir şekilde COVID-19 semptomlarına benzemekteydi. Tekrarlanan PCR testleri ve BT sonuçları hastanın COVID-19 olmadığını göstermiştir. Bir hafta sonra ise hastanın semptomları gerilemiş ve laboratuvar bulguları, fizik muayene bulgularıyla birlikte normale dönmüştür. Hastanın bu durumunun zoledronik asit infüzyonuna bağlı olduğu düşünüldü. Klinik durumun kafa karıştırıcı olabileceği COVID-19 döneminde zoledronik asit infüzyonu sonrası akut faz reaksiyonuna dikkat çekmek istiyoruz.
Anahtar Kelime: Zoledronik asit COVID-19 grip benzeri semptomlar lenfopeni

Belge Türü: Makale Makale Türü: Olgu Sunumu Erişim Türü: Erişime Açık
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APA Koygun Ö, Kurşunoğlu N, Özışık H, saygili f, sarer yurekli b (2023). Acute phase reaction with zoledronic acid infusion mimicking COVID-19. , 473 - 476.
Chicago Koygun Öyküm Deniz,Kurşunoğlu Niyazi Emre,Özışık Hatice,saygili fusun,sarer yurekli banu Acute phase reaction with zoledronic acid infusion mimicking COVID-19. (2023): 473 - 476.
MLA Koygun Öyküm Deniz,Kurşunoğlu Niyazi Emre,Özışık Hatice,saygili fusun,sarer yurekli banu Acute phase reaction with zoledronic acid infusion mimicking COVID-19. , 2023, ss.473 - 476.
AMA Koygun Ö,Kurşunoğlu N,Özışık H,saygili f,sarer yurekli b Acute phase reaction with zoledronic acid infusion mimicking COVID-19. . 2023; 473 - 476.
Vancouver Koygun Ö,Kurşunoğlu N,Özışık H,saygili f,sarer yurekli b Acute phase reaction with zoledronic acid infusion mimicking COVID-19. . 2023; 473 - 476.
IEEE Koygun Ö,Kurşunoğlu N,Özışık H,saygili f,sarer yurekli b "Acute phase reaction with zoledronic acid infusion mimicking COVID-19." , ss.473 - 476, 2023.
ISNAD Koygun, Öyküm Deniz vd. "Acute phase reaction with zoledronic acid infusion mimicking COVID-19". (2023), 473-476.
APA Koygun Ö, Kurşunoğlu N, Özışık H, saygili f, sarer yurekli b (2023). Acute phase reaction with zoledronic acid infusion mimicking COVID-19. Ege Tıp Dergisi, 62(3), 473 - 476.
Chicago Koygun Öyküm Deniz,Kurşunoğlu Niyazi Emre,Özışık Hatice,saygili fusun,sarer yurekli banu Acute phase reaction with zoledronic acid infusion mimicking COVID-19. Ege Tıp Dergisi 62, no.3 (2023): 473 - 476.
MLA Koygun Öyküm Deniz,Kurşunoğlu Niyazi Emre,Özışık Hatice,saygili fusun,sarer yurekli banu Acute phase reaction with zoledronic acid infusion mimicking COVID-19. Ege Tıp Dergisi, vol.62, no.3, 2023, ss.473 - 476.
AMA Koygun Ö,Kurşunoğlu N,Özışık H,saygili f,sarer yurekli b Acute phase reaction with zoledronic acid infusion mimicking COVID-19. Ege Tıp Dergisi. 2023; 62(3): 473 - 476.
Vancouver Koygun Ö,Kurşunoğlu N,Özışık H,saygili f,sarer yurekli b Acute phase reaction with zoledronic acid infusion mimicking COVID-19. Ege Tıp Dergisi. 2023; 62(3): 473 - 476.
IEEE Koygun Ö,Kurşunoğlu N,Özışık H,saygili f,sarer yurekli b "Acute phase reaction with zoledronic acid infusion mimicking COVID-19." Ege Tıp Dergisi, 62, ss.473 - 476, 2023.
ISNAD Koygun, Öyküm Deniz vd. "Acute phase reaction with zoledronic acid infusion mimicking COVID-19". Ege Tıp Dergisi 62/3 (2023), 473-476.