Vitamin D, VDR, and VDBP Levels Correlate with Anti-inflammatory Cytokine Profile in FMS Patients

Ellergezen, Pinar; alp, alev; ÇAVUN, SINAN

doi:10.37990/medr.1131305

Vitamin D, VDR, and VDBP Levels Correlate with Anti-inflammatory Cytokine Profile in FMS Patients

Pınar ELLERGEZEN, (Uludağ Üniversitesi Tıp Fakültesi, Tıbbi Farmakoloji Anabilim Dalı, Bursa, Türkiye)

Alev ALP, (Uludağ Üniversitesi Tıp Fakültesi, Fiziksel Tıp ve Rehabilitasyon Anabilim Dalı, Bursa, Türkiye)

Sinan ÇAVUN (Uludağ Üniversitesi Tıp Fakültesi, Tıbbi Farmakoloji Anabilim Dalı, Bursa, Türkiye)

Medical records-international medical journal (Online)

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Yıl: 2023 Cilt: 5 Sayı: 1 Sayfa Aralığı: 24 - 28 Metin Dili: İngilizce DOI: 10.37990/medr.1131305 İndeks Tarihi: 21-09-2023

Vitamin D, VDR, and VDBP Levels Correlate with Anti-inflammatory Cytokine Profile in FMS Patients

Öz:

Aim: The major target of this research is to examine whether there is any connection between the levels of vitamin D and anti-inflammatory mediators in patients with fibromyalgia syndrome (FMS). Materials and Methods: The study contains 30 FMS diagnosed and 25 healthy female individuals and the determination of FMS was made according to the standards of 2010 American College of Rheumatology (ACR). Vitamin D, vitamin D receptor (VDR), vitamin D binding protein (VDBP) levels, and anti-inflammatory cytokine (IL-4, IL-10, TGF-β) levels in the serum of patients with FMS and healthy individuals were measured using enzyme-linked immunosorbent assay (ELISA).Results: The concentrations of vitamin D, VDR, and VDBP were determined to be higher in healthy controls than in patients with FMS (p<0.001). Correlating with this, IL-4, IL-10, and TGF-β levels were measured remarkably higher in the healthy group than in the FMS patients (p<0.001). Conclusion: Low vitamin D levels may cause a decrease in anti-inflammatory cytokine levels and their immunosuppressive effect in FMS.

Anahtar Kelime: anti-inflammatory cytokines vitamin D fibromyalgia syndrome

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Ellergezen P, alp a, ÇAVUN S (2023). Vitamin D, VDR, and VDBP Levels Correlate with Anti-inflammatory Cytokine Profile in FMS Patients. , 24 - 28. 10.37990/medr.1131305
Chicago	Ellergezen Pinar,alp alev,ÇAVUN SINAN Vitamin D, VDR, and VDBP Levels Correlate with Anti-inflammatory Cytokine Profile in FMS Patients. (2023): 24 - 28. 10.37990/medr.1131305
MLA	Ellergezen Pinar,alp alev,ÇAVUN SINAN Vitamin D, VDR, and VDBP Levels Correlate with Anti-inflammatory Cytokine Profile in FMS Patients. , 2023, ss.24 - 28. 10.37990/medr.1131305
AMA	Ellergezen P,alp a,ÇAVUN S Vitamin D, VDR, and VDBP Levels Correlate with Anti-inflammatory Cytokine Profile in FMS Patients. . 2023; 24 - 28. 10.37990/medr.1131305
Vancouver	Ellergezen P,alp a,ÇAVUN S Vitamin D, VDR, and VDBP Levels Correlate with Anti-inflammatory Cytokine Profile in FMS Patients. . 2023; 24 - 28. 10.37990/medr.1131305
IEEE	Ellergezen P,alp a,ÇAVUN S "Vitamin D, VDR, and VDBP Levels Correlate with Anti-inflammatory Cytokine Profile in FMS Patients." , ss.24 - 28, 2023. 10.37990/medr.1131305
ISNAD	Ellergezen, Pinar vd. "Vitamin D, VDR, and VDBP Levels Correlate with Anti-inflammatory Cytokine Profile in FMS Patients". (2023), 24-28. https://doi.org/10.37990/medr.1131305

APA	Ellergezen P, alp a, ÇAVUN S (2023). Vitamin D, VDR, and VDBP Levels Correlate with Anti-inflammatory Cytokine Profile in FMS Patients. Medical records-international medical journal (Online), 5(1), 24 - 28. 10.37990/medr.1131305
Chicago	Ellergezen Pinar,alp alev,ÇAVUN SINAN Vitamin D, VDR, and VDBP Levels Correlate with Anti-inflammatory Cytokine Profile in FMS Patients. Medical records-international medical journal (Online) 5, no.1 (2023): 24 - 28. 10.37990/medr.1131305
MLA	Ellergezen Pinar,alp alev,ÇAVUN SINAN Vitamin D, VDR, and VDBP Levels Correlate with Anti-inflammatory Cytokine Profile in FMS Patients. Medical records-international medical journal (Online), vol.5, no.1, 2023, ss.24 - 28. 10.37990/medr.1131305
AMA	Ellergezen P,alp a,ÇAVUN S Vitamin D, VDR, and VDBP Levels Correlate with Anti-inflammatory Cytokine Profile in FMS Patients. Medical records-international medical journal (Online). 2023; 5(1): 24 - 28. 10.37990/medr.1131305
Vancouver	Ellergezen P,alp a,ÇAVUN S Vitamin D, VDR, and VDBP Levels Correlate with Anti-inflammatory Cytokine Profile in FMS Patients. Medical records-international medical journal (Online). 2023; 5(1): 24 - 28. 10.37990/medr.1131305
IEEE	Ellergezen P,alp a,ÇAVUN S "Vitamin D, VDR, and VDBP Levels Correlate with Anti-inflammatory Cytokine Profile in FMS Patients." Medical records-international medical journal (Online), 5, ss.24 - 28, 2023. 10.37990/medr.1131305
ISNAD	Ellergezen, Pinar vd. "Vitamin D, VDR, and VDBP Levels Correlate with Anti-inflammatory Cytokine Profile in FMS Patients". Medical records-international medical journal (Online) 5/1 (2023), 24-28. https://doi.org/10.37990/medr.1131305