ELECTROCHEMICAL INVESTIGATION OF OTILONIUM BROMIDE USING BORON-DOPED DIAMOND AND GLASSY CARBON ELECTRODES
Yıl: 2023 Cilt: 47 Sayı: 3 Sayfa Aralığı: 1003 - 1010 Metin Dili: İngilizce DOI: 10.33483/jfpau.1344014 İndeks Tarihi: 26-09-2023
ELECTROCHEMICAL INVESTIGATION OF OTILONIUM BROMIDE USING BORON-DOPED DIAMOND AND GLASSY CARBON ELECTRODES
Öz: Objective: Using cyclic (CV) and differential pulse (DPV) voltammetric techniques, the electrochemical research of otilonium bromide (OTB) was carried out over a wide pH range (0.3–12) at glassy carbon electrodes (GCE) and boron-doped diamond electrodes (BDDE). The typical electrochemical behavior of OTB was identified as being dependent on the type of working electrode and pH. This research aims to provide a brand-new electroanalytical technique for measuring OTB in buffer solutions. Material and Method: All experiments employed the typical three-electrode cell of 10 ml capacity in conjunction with a platinum wire counter electrode, a BDDE and GCE working electrode, and an Ag/AgCl reference electrode. NOVA 1.8 software and an AUTOLAB 204 potentiostat/galvanostat were used for electrochemical measurements. Result and Discussion: The electrochemical behavior of OTB, which belongs to a class of drugs called 'antispasmodics' (spasm and cramps reliever), primarily used to treat irritable bowel syndrome (IBS), and other gastrointestinal conditions characterized by motility problems, painful bowel spasms and distension (swelling and bloating in the belly area), was examined in 0.1 M H2SO4 at BDDE and GCE. The electrooxidation mechanism was also investigated by conducting CV investigations at various pH levels throughout a broad pH range (pH 0.3-12.0). Understanding the mechanism was aided by scan rate investigations, which revealed that diffusion was controlled for both electrodes. The proposed technique was successfully used to determine OTB under optimal conditions.
Anahtar Kelime: CAMSI KARBON VE BOR KATKILI ELMAS ELEKTROTLAR KULLANARAK OTİLONYUM BROMÜRÜN ELEKTROKİMYASAL DEĞERLENDİRİLMESİ
Öz: Amaç: Döngüsel (CV) ve diferansiyel darbe (DPV) voltametrik teknikler kullanılarak, otilonyum bromürün (OTB) elektrokimyasal araştırması, bor katkılı elmas elektrotlarda (BDDE) ve camsı karbon elektrotlarda (GCE) geniş bir pH aralığında (0.3–12) gerçekleştirildi. OTB'nin tipik elektrokimyasal davranışının, çalışan elektrot tipine ve pH'a bağlı olduğu tespit edildi. Bu araştırmanın amacı, tampon çözeltilerde OTB'yi ölçmek için yepyeni bir elektroanalitik teknik sağlamaktır. Gereç ve Yöntem: 10 ml kapasiteli tipik tek bölmeli üç elektrotlu hücre, tüm çalışmalarda bir BDDE ve GCE çalışma elektrotu, bir platin tel karşıt elektrot ve bir Ag/AgCl referans elektrotu ile birlikte kullanıldı. Elektrokimyasal ölçümleri gerçekleştirmek için NOVA 1.8 yazılımı ve bir AUTOLAB 204 potansiyostat/galvanostat kullanıldı. Sonuç ve Tartışma: "Antispazmodikler" (spazm ve kramp giderici) adı verilen bir ilaç sınıfına ait olan OTB'nin elektrokimyasal davranışı, öncelikle hassas bağırsak sendromunu (IBS) ve hareketlilik sorunları, ağrılı bağırsak spazmları ve şişkinliği (şişme) ile karakterize edilen diğer gastrointestinal rahatsızlıkları tedavi etmek için kullanılır. ve göbek bölgesinde şişkinlik), GCE ve BDDE'de 0.1 M H2SO4'te incelenmiştir. Geniş bir pH aralığı (pH 0.3-12.0) boyunca çeşitli pH seviyelerinde CV araştırmaları yapılarak elektrooksidasyon mekanizması da araştırıldı. Mekanizmanın anlaşılması, difüzyonun her iki elektrot için de kontrol edildiğini ortaya koyan tarama hızı araştırmalarıyla desteklendi. Önerilen yöntem, optimal koşullar altında OTB'yi belirlemek için başarıyla kullanılmıştır.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | Karadurmus L, Bellur Atici E, OZKAN S (2023). ELECTROCHEMICAL INVESTIGATION OF OTILONIUM BROMIDE USING BORON-DOPED DIAMOND AND GLASSY CARBON ELECTRODES. , 1003 - 1010. 10.33483/jfpau.1344014 |
| Chicago | Karadurmus Leyla,Bellur Atici Esen,OZKAN Sibel ELECTROCHEMICAL INVESTIGATION OF OTILONIUM BROMIDE USING BORON-DOPED DIAMOND AND GLASSY CARBON ELECTRODES. (2023): 1003 - 1010. 10.33483/jfpau.1344014 |
| MLA | Karadurmus Leyla,Bellur Atici Esen,OZKAN Sibel ELECTROCHEMICAL INVESTIGATION OF OTILONIUM BROMIDE USING BORON-DOPED DIAMOND AND GLASSY CARBON ELECTRODES. , 2023, ss.1003 - 1010. 10.33483/jfpau.1344014 |
| AMA | Karadurmus L,Bellur Atici E,OZKAN S ELECTROCHEMICAL INVESTIGATION OF OTILONIUM BROMIDE USING BORON-DOPED DIAMOND AND GLASSY CARBON ELECTRODES. . 2023; 1003 - 1010. 10.33483/jfpau.1344014 |
| Vancouver | Karadurmus L,Bellur Atici E,OZKAN S ELECTROCHEMICAL INVESTIGATION OF OTILONIUM BROMIDE USING BORON-DOPED DIAMOND AND GLASSY CARBON ELECTRODES. . 2023; 1003 - 1010. 10.33483/jfpau.1344014 |
| IEEE | Karadurmus L,Bellur Atici E,OZKAN S "ELECTROCHEMICAL INVESTIGATION OF OTILONIUM BROMIDE USING BORON-DOPED DIAMOND AND GLASSY CARBON ELECTRODES." , ss.1003 - 1010, 2023. 10.33483/jfpau.1344014 |
| ISNAD | Karadurmus, Leyla vd. "ELECTROCHEMICAL INVESTIGATION OF OTILONIUM BROMIDE USING BORON-DOPED DIAMOND AND GLASSY CARBON ELECTRODES". (2023), 1003-1010. https://doi.org/10.33483/jfpau.1344014 |
| APA | Karadurmus L, Bellur Atici E, OZKAN S (2023). ELECTROCHEMICAL INVESTIGATION OF OTILONIUM BROMIDE USING BORON-DOPED DIAMOND AND GLASSY CARBON ELECTRODES. Ankara Üniversitesi Eczacılık Fakültesi Dergisi, 47(3), 1003 - 1010. 10.33483/jfpau.1344014 |
| Chicago | Karadurmus Leyla,Bellur Atici Esen,OZKAN Sibel ELECTROCHEMICAL INVESTIGATION OF OTILONIUM BROMIDE USING BORON-DOPED DIAMOND AND GLASSY CARBON ELECTRODES. Ankara Üniversitesi Eczacılık Fakültesi Dergisi 47, no.3 (2023): 1003 - 1010. 10.33483/jfpau.1344014 |
| MLA | Karadurmus Leyla,Bellur Atici Esen,OZKAN Sibel ELECTROCHEMICAL INVESTIGATION OF OTILONIUM BROMIDE USING BORON-DOPED DIAMOND AND GLASSY CARBON ELECTRODES. Ankara Üniversitesi Eczacılık Fakültesi Dergisi, vol.47, no.3, 2023, ss.1003 - 1010. 10.33483/jfpau.1344014 |
| AMA | Karadurmus L,Bellur Atici E,OZKAN S ELECTROCHEMICAL INVESTIGATION OF OTILONIUM BROMIDE USING BORON-DOPED DIAMOND AND GLASSY CARBON ELECTRODES. Ankara Üniversitesi Eczacılık Fakültesi Dergisi. 2023; 47(3): 1003 - 1010. 10.33483/jfpau.1344014 |
| Vancouver | Karadurmus L,Bellur Atici E,OZKAN S ELECTROCHEMICAL INVESTIGATION OF OTILONIUM BROMIDE USING BORON-DOPED DIAMOND AND GLASSY CARBON ELECTRODES. Ankara Üniversitesi Eczacılık Fakültesi Dergisi. 2023; 47(3): 1003 - 1010. 10.33483/jfpau.1344014 |
| IEEE | Karadurmus L,Bellur Atici E,OZKAN S "ELECTROCHEMICAL INVESTIGATION OF OTILONIUM BROMIDE USING BORON-DOPED DIAMOND AND GLASSY CARBON ELECTRODES." Ankara Üniversitesi Eczacılık Fakültesi Dergisi, 47, ss.1003 - 1010, 2023. 10.33483/jfpau.1344014 |
| ISNAD | Karadurmus, Leyla vd. "ELECTROCHEMICAL INVESTIGATION OF OTILONIUM BROMIDE USING BORON-DOPED DIAMOND AND GLASSY CARBON ELECTRODES". Ankara Üniversitesi Eczacılık Fakültesi Dergisi 47/3 (2023), 1003-1010. https://doi.org/10.33483/jfpau.1344014 |
