PREPARATION AND IN VITRO CHARACTERIZATION OF LIDOCAINE LOADED ALOE VERA GEL FORMULATION FOR THE TREATMENT OF BURN WOUNDS
Yıl: 2023 Cilt: 47 Sayı: 3 Sayfa Aralığı: 1041 - 1052 Metin Dili: İngilizce DOI: 10.33483/jfpau.1319262 İndeks Tarihi: 26-09-2023
PREPARATION AND IN VITRO CHARACTERIZATION OF LIDOCAINE LOADED ALOE VERA GEL FORMULATION FOR THE TREATMENT OF BURN WOUNDS
Öz: Objective: In this study, topically applied in situ gel formulations were aimed to design for the modulation of burns, with the active ingredient lidocaine and the gel gained from the Aloe vera plant. The prepared in situ gels were in the liquid form at the room temperature and gelled at the body temperature and adhered to the wound surface, resulting in higher drug residence time. By improving the characteristic properties of the in situ gels, it is aimed to improve patient compliance by obtaining higher local lidocaine concentration. Material and Method: In situ gel formulations separated by giving different gel codes were examined with characteristic analyses. Within the scope of these examinations, measurement of gelation temperature, pH measurement, in vitro lidocaine release, viscosity and rheological properties and the texture profile of the formulations were determined. Result and Discussion: Poloxamer 407 based in situ gels designed for topical treatment containing Aloe vera gel and lidocaine have been shown to increase skin residence time. Among the formulations prepared with different content ratios of the polymers Poloxamer 407, Poloxamer 188, HPMC and CMC, the gels coded F5 and A21 showed acceptable gelation temperature for topical use and sustained lidocaine release for 24 hours. According to these findings, it can be revealed that Poloxamer 407-HPMC based in situ gel formulation may be an effective alternative for topical burn treatment.
Anahtar Kelime: YANIK TEDAVİSİNDE KULLANILMAK ÜZERE LİDOKAİN İÇEREN ALOE VERA JEL FORMÜLASYONUNUN HAZIRLANMASI VE İN VİTRO KARAKTERİZASYONU
Öz: Amaç: Bu çalışma kapsamında Aloe vera bitkisinden elde edilen jelin, lidokain etken maddesi ile birlikte yanık tedavisinde topikal olarak uygulanacak in situ jel formülasyonlarının geliştirilmesi amaçlanmıştır. Formülasyonların karakteristik özellikleri iyileştirilerek, oda sıcaklığında sıvı formda olan in situ jellerin vücut sıcaklığında jelleşerek yara yüzeyine yapışma suretiyle daha yüksek lokal ilaç konsantrasyonu elde edilerek hasta uyuncunun artırılması hedeflenmiştir. Gereç ve Yöntem: Farklı jel kodları verilerek ayrılan in situ jel formülasyonlarının karakteristik özellikleri analiz edilmiştir. Bu incelemeler kapsamında jelleşme sıcaklığının tespiti, pH ölçümü, in vitro lidokain salım çalışması gerçekleştirilmiş ve in situ jellerin viskozite ve reolojik özellikleri ile tekstür profil analizleri değerlendirilmiştir. Sonuç ve Tartışma: Aloe vera jeli ve lidokain içeren, topikal tedavi için tasarlanmış Poloxamer 407 bazlı in situ jellerin deri üzerinde kalış süresini uzattığı ve lokal lidokain konsantrasyonunu artırabileceği belirlenmiştir. Poloxamer 407, Poloxamer 188, HPMC ve CMC’nin farklı oranları ile hazırlanan in situ jel formülasyonları arasında F5 ve A21 kodlu jeller topikal kullanım için kabul edilebilir jelleşme sıcaklığı göstermiş ve 24 saat lidokain salımı gerçekleştirmiş olup, Aloe vera ve lidokain içeren Poloxamer 407-HPMC bazlı in situ jel formülasyonunun topikal yanık tedavisinde etkili bir alternatif olabileceği sonucuna varılmıştır.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | GÜVEN U, Cevikelli T, Songüloğlu S, demirci s (2023). PREPARATION AND IN VITRO CHARACTERIZATION OF LIDOCAINE LOADED ALOE VERA GEL FORMULATION FOR THE TREATMENT OF BURN WOUNDS. , 1041 - 1052. 10.33483/jfpau.1319262 |
| Chicago | GÜVEN UMAY MERVE,Cevikelli Tilbe,Songüloğlu Sanem,demirci serpil PREPARATION AND IN VITRO CHARACTERIZATION OF LIDOCAINE LOADED ALOE VERA GEL FORMULATION FOR THE TREATMENT OF BURN WOUNDS. (2023): 1041 - 1052. 10.33483/jfpau.1319262 |
| MLA | GÜVEN UMAY MERVE,Cevikelli Tilbe,Songüloğlu Sanem,demirci serpil PREPARATION AND IN VITRO CHARACTERIZATION OF LIDOCAINE LOADED ALOE VERA GEL FORMULATION FOR THE TREATMENT OF BURN WOUNDS. , 2023, ss.1041 - 1052. 10.33483/jfpau.1319262 |
| AMA | GÜVEN U,Cevikelli T,Songüloğlu S,demirci s PREPARATION AND IN VITRO CHARACTERIZATION OF LIDOCAINE LOADED ALOE VERA GEL FORMULATION FOR THE TREATMENT OF BURN WOUNDS. . 2023; 1041 - 1052. 10.33483/jfpau.1319262 |
| Vancouver | GÜVEN U,Cevikelli T,Songüloğlu S,demirci s PREPARATION AND IN VITRO CHARACTERIZATION OF LIDOCAINE LOADED ALOE VERA GEL FORMULATION FOR THE TREATMENT OF BURN WOUNDS. . 2023; 1041 - 1052. 10.33483/jfpau.1319262 |
| IEEE | GÜVEN U,Cevikelli T,Songüloğlu S,demirci s "PREPARATION AND IN VITRO CHARACTERIZATION OF LIDOCAINE LOADED ALOE VERA GEL FORMULATION FOR THE TREATMENT OF BURN WOUNDS." , ss.1041 - 1052, 2023. 10.33483/jfpau.1319262 |
| ISNAD | GÜVEN, UMAY MERVE vd. "PREPARATION AND IN VITRO CHARACTERIZATION OF LIDOCAINE LOADED ALOE VERA GEL FORMULATION FOR THE TREATMENT OF BURN WOUNDS". (2023), 1041-1052. https://doi.org/10.33483/jfpau.1319262 |
| APA | GÜVEN U, Cevikelli T, Songüloğlu S, demirci s (2023). PREPARATION AND IN VITRO CHARACTERIZATION OF LIDOCAINE LOADED ALOE VERA GEL FORMULATION FOR THE TREATMENT OF BURN WOUNDS. Ankara Üniversitesi Eczacılık Fakültesi Dergisi, 47(3), 1041 - 1052. 10.33483/jfpau.1319262 |
| Chicago | GÜVEN UMAY MERVE,Cevikelli Tilbe,Songüloğlu Sanem,demirci serpil PREPARATION AND IN VITRO CHARACTERIZATION OF LIDOCAINE LOADED ALOE VERA GEL FORMULATION FOR THE TREATMENT OF BURN WOUNDS. Ankara Üniversitesi Eczacılık Fakültesi Dergisi 47, no.3 (2023): 1041 - 1052. 10.33483/jfpau.1319262 |
| MLA | GÜVEN UMAY MERVE,Cevikelli Tilbe,Songüloğlu Sanem,demirci serpil PREPARATION AND IN VITRO CHARACTERIZATION OF LIDOCAINE LOADED ALOE VERA GEL FORMULATION FOR THE TREATMENT OF BURN WOUNDS. Ankara Üniversitesi Eczacılık Fakültesi Dergisi, vol.47, no.3, 2023, ss.1041 - 1052. 10.33483/jfpau.1319262 |
| AMA | GÜVEN U,Cevikelli T,Songüloğlu S,demirci s PREPARATION AND IN VITRO CHARACTERIZATION OF LIDOCAINE LOADED ALOE VERA GEL FORMULATION FOR THE TREATMENT OF BURN WOUNDS. Ankara Üniversitesi Eczacılık Fakültesi Dergisi. 2023; 47(3): 1041 - 1052. 10.33483/jfpau.1319262 |
| Vancouver | GÜVEN U,Cevikelli T,Songüloğlu S,demirci s PREPARATION AND IN VITRO CHARACTERIZATION OF LIDOCAINE LOADED ALOE VERA GEL FORMULATION FOR THE TREATMENT OF BURN WOUNDS. Ankara Üniversitesi Eczacılık Fakültesi Dergisi. 2023; 47(3): 1041 - 1052. 10.33483/jfpau.1319262 |
| IEEE | GÜVEN U,Cevikelli T,Songüloğlu S,demirci s "PREPARATION AND IN VITRO CHARACTERIZATION OF LIDOCAINE LOADED ALOE VERA GEL FORMULATION FOR THE TREATMENT OF BURN WOUNDS." Ankara Üniversitesi Eczacılık Fakültesi Dergisi, 47, ss.1041 - 1052, 2023. 10.33483/jfpau.1319262 |
| ISNAD | GÜVEN, UMAY MERVE vd. "PREPARATION AND IN VITRO CHARACTERIZATION OF LIDOCAINE LOADED ALOE VERA GEL FORMULATION FOR THE TREATMENT OF BURN WOUNDS". Ankara Üniversitesi Eczacılık Fakültesi Dergisi 47/3 (2023), 1041-1052. https://doi.org/10.33483/jfpau.1319262 |
