THE POSSIBLE RELATIONSHIPS BETWEEN SOME GENE POLYMORPHISMS AND SJOGREN’S SYNDROME

TERZİ, ÜLKÜ; ATES, ILKER

doi:10.33483/jfpau.1328811

THE POSSIBLE RELATIONSHIPS BETWEEN SOME GENE POLYMORPHISMS AND SJOGREN’S SYNDROME

Ülkü TERZİ, (Ankara Üniversitesi, Eczacılık Fakültesi, Toksikoloji Anabilim Dalı, 06560, Ankara, Türkiye)

İlker ATEŞ (Ankara Üniversitesi, Eczacılık Fakültesi, Toksikoloji Anabilim Dalı, 06560, Ankara, Türkiye)

Ankara Üniversitesi Eczacılık Fakültesi Dergisi

12 1

Yıl: 2023 Cilt: 47 Sayı: 3 Sayfa Aralığı: 1141 - 1154 Metin Dili: İngilizce DOI: 10.33483/jfpau.1328811 İndeks Tarihi: 26-09-2023

THE POSSIBLE RELATIONSHIPS BETWEEN SOME GENE POLYMORPHISMS AND SJOGREN’S SYNDROME

Öz:

Objective: Sjögren’s syndrome is a complex and widespread autoimmune disease whose pathogenesis is not fully elucidated and environmental and genetic factors affect the development of the disease. In order to reveal the effect of genetic contribution, studies have been conducted on the genes previously shown to play a role in other autoimmune diseases such as systemic lupus erythromatosus. In addition, two GWAS studies were conducted to investigate the role of more genes in the disease by screening the entire genome and the relationship of previously unknown genes with SS was shown. Result and Discussion: Studies are being conducted with spontaneous and genetically modified animal models in order to better reveal the relationship between SS and genes and to reinforce the data obtained from humans. In this study, the relationship between the genes previously studied in other autoimmune diseases and the genes associated with SS in GWAS studies and the possible pathways that may contribute to the pathogenesis of the disease through related genes were investigated.

Anahtar Kelime: Autoiımmune disease gene polymorphisms genetic toxic effects genotoxicity Sjögren’s syndrome

SJÖGREN SENDROMU İLE BAZI GEN POLİMORFİZMLERİ ARASINDAKİ OLASI BAĞLANTILAR

Öz:

Amaç: Sjögren sendromu hala patogenezisi tam olarak aydınlatılamamış, hastalık gelişimini çevresel ve genetik faktörlerin etkilediği kompleks ve yaygın bir otoimmün hastalıktır. Genetik katkının etkisini ortaya koymak için daha önce sistemik lupus eritromatozus gibi diğer otoimmün hastalıklarda rolü gösterilen genler üzerinde bu genlerin SS ile ilişkisini ortaya koymak için çalışmalar yapılmıştır. Ayrıca iki GWAS çalışmasıyla da tüm genom taranarak daha fazla genin hastalıkta rolü incelenmiş ve daha önce SS ile ilişkisi bilinmeyen genlerin SS ile ilişkisi gösterilmiştir. Sonuç ve Tartışma: SS’in genlerle ilişkisini daha iyi ortaya koymak ve insanlardan elde edilen verilerin pekiştirilmesi için spontan ve genetiği modifiye edilmiş hayvan modelleriyle de çalışmalar yürütülmektedir. Bu çalışmada daha önce diğer otoimmün hastalıklarda incelenen genler ile GWAS çalışmalarında ilişkili bulunan genlerin SS ile ilişkisi, ilişkili bulunan genler üzerinden hastalığın patogenezisine katkısı olabilecek olası yolaklar irdelenmiştir.

Anahtar Kelime: Gen polimorfizmi genetik toksik etkiler genotoksisite otoimmün hastalık Sjögren sendromu

Belge Türü: Makale Makale Türü: Derleme Erişim Türü: Erişime Açık

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APA	TERZİ Ü, ATES I (2023). THE POSSIBLE RELATIONSHIPS BETWEEN SOME GENE POLYMORPHISMS AND SJOGREN’S SYNDROME. , 1141 - 1154. 10.33483/jfpau.1328811
Chicago	TERZİ ÜLKÜ,ATES ILKER THE POSSIBLE RELATIONSHIPS BETWEEN SOME GENE POLYMORPHISMS AND SJOGREN’S SYNDROME. (2023): 1141 - 1154. 10.33483/jfpau.1328811
MLA	TERZİ ÜLKÜ,ATES ILKER THE POSSIBLE RELATIONSHIPS BETWEEN SOME GENE POLYMORPHISMS AND SJOGREN’S SYNDROME. , 2023, ss.1141 - 1154. 10.33483/jfpau.1328811
AMA	TERZİ Ü,ATES I THE POSSIBLE RELATIONSHIPS BETWEEN SOME GENE POLYMORPHISMS AND SJOGREN’S SYNDROME. . 2023; 1141 - 1154. 10.33483/jfpau.1328811
Vancouver	TERZİ Ü,ATES I THE POSSIBLE RELATIONSHIPS BETWEEN SOME GENE POLYMORPHISMS AND SJOGREN’S SYNDROME. . 2023; 1141 - 1154. 10.33483/jfpau.1328811
IEEE	TERZİ Ü,ATES I "THE POSSIBLE RELATIONSHIPS BETWEEN SOME GENE POLYMORPHISMS AND SJOGREN’S SYNDROME." , ss.1141 - 1154, 2023. 10.33483/jfpau.1328811
ISNAD	TERZİ, ÜLKÜ - ATES, ILKER. "THE POSSIBLE RELATIONSHIPS BETWEEN SOME GENE POLYMORPHISMS AND SJOGREN’S SYNDROME". (2023), 1141-1154. https://doi.org/10.33483/jfpau.1328811

APA	TERZİ Ü, ATES I (2023). THE POSSIBLE RELATIONSHIPS BETWEEN SOME GENE POLYMORPHISMS AND SJOGREN’S SYNDROME. Ankara Üniversitesi Eczacılık Fakültesi Dergisi, 47(3), 1141 - 1154. 10.33483/jfpau.1328811
Chicago	TERZİ ÜLKÜ,ATES ILKER THE POSSIBLE RELATIONSHIPS BETWEEN SOME GENE POLYMORPHISMS AND SJOGREN’S SYNDROME. Ankara Üniversitesi Eczacılık Fakültesi Dergisi 47, no.3 (2023): 1141 - 1154. 10.33483/jfpau.1328811
MLA	TERZİ ÜLKÜ,ATES ILKER THE POSSIBLE RELATIONSHIPS BETWEEN SOME GENE POLYMORPHISMS AND SJOGREN’S SYNDROME. Ankara Üniversitesi Eczacılık Fakültesi Dergisi, vol.47, no.3, 2023, ss.1141 - 1154. 10.33483/jfpau.1328811
AMA	TERZİ Ü,ATES I THE POSSIBLE RELATIONSHIPS BETWEEN SOME GENE POLYMORPHISMS AND SJOGREN’S SYNDROME. Ankara Üniversitesi Eczacılık Fakültesi Dergisi. 2023; 47(3): 1141 - 1154. 10.33483/jfpau.1328811
Vancouver	TERZİ Ü,ATES I THE POSSIBLE RELATIONSHIPS BETWEEN SOME GENE POLYMORPHISMS AND SJOGREN’S SYNDROME. Ankara Üniversitesi Eczacılık Fakültesi Dergisi. 2023; 47(3): 1141 - 1154. 10.33483/jfpau.1328811
IEEE	TERZİ Ü,ATES I "THE POSSIBLE RELATIONSHIPS BETWEEN SOME GENE POLYMORPHISMS AND SJOGREN’S SYNDROME." Ankara Üniversitesi Eczacılık Fakültesi Dergisi, 47, ss.1141 - 1154, 2023. 10.33483/jfpau.1328811
ISNAD	TERZİ, ÜLKÜ - ATES, ILKER. "THE POSSIBLE RELATIONSHIPS BETWEEN SOME GENE POLYMORPHISMS AND SJOGREN’S SYNDROME". Ankara Üniversitesi Eczacılık Fakültesi Dergisi 47/3 (2023), 1141-1154. https://doi.org/10.33483/jfpau.1328811