Coronary Artery Bypass Surgery in Patients Receiving Dual Antiplatelet Therapy and the Impact of Preoperative Vitamin D Levels During COVID-19 Pandemic: An Observational Single Center Study
Yıl: 2023 Cilt: 33 Sayı: 4 Sayfa Aralığı: 434 - 438 Metin Dili: İngilizce DOI: 10.54005/geneltip.1281015 İndeks Tarihi: 26-09-2023
Coronary Artery Bypass Surgery in Patients Receiving Dual Antiplatelet Therapy and the Impact of Preoperative Vitamin D Levels During COVID-19 Pandemic: An Observational Single Center Study
Öz: Objective: The COVID-19 pandemic has led to a surge in catheter-based interventions as elective surgeries were postponed. However, there has been a simultaneous rise in emergency CABG surgeries due to stent thrombosis or catheter-related complications. The potential impact of vitamin D on the immune system has also gained attention during the pandemic. We aimed to investigate the impact of preoperative dual anti-platelet (DAPT) usage and vitamin D levels of those patients who underwent CABG on postoperative outcomes. Materials and methods: This retrospective study was conducted between March 23, 2020, and December 30, 2021. The study included 63 patients who underwent elective and emergency CABG while on dual antiplatelet therapy. D vitamin levels were obtained from all the patients preoperatively. Results: Fifty-one of the 63 patients were males and 12 were females. The mean age was 62.69 ± 8.43 years. 15 patients (24%) were on Clopidogrel and Acetylsalicylic acid (ASA) and 48 patients (76%) were on Ticagrelor and ASA preoperatively. Off-pump CABG was performed in 21 patients (33%). One patient had a stroke (1.6 %). The amount of drainage was significantly higher in patients using Ticagrelor and (ASA) (p = 0.015). The mean vitamin D level was 13.94 ± 5.24 ng/mL ranging from 3.38 ng/mL to 24.99 ng/mL, Vitamin D levels were significantly lower in female patients compared to males (p = 0.004). Conclusion: CABG surgery in patients receiving DAPT presents unique challenges and requires careful management to minimize bleeding complications. Additionally, maintaining adequate vitamin D levels preoperatively may improve postoperative outcomes.
Anahtar Kelime: COVID-19 Pandemi Döneminde Koroner Bypass Cerrahisi Uygulanan Hastalarda Preoperatif İkili Antiplatelet Tedavi Kullanımı ve D Vitamini Düzeylerinin Postoperatif Sonuçlara Etkisi: Gözlemsel Tek Merkezli Çalışma
Öz: Amaç: COVID-19 salgını, elektif cerrahi girişimLer ertelendikçe kateter bazlı müdahalelerde artışa neden oldu. Bununla birlikte, stent trombozu veya kateter ilişkili komplikasyonlar nedeniyle acil coroner bypass ameliyatlarında da eş zamanlı bir artış olmuştur. D vitamininin bağışıklık sistemi üzerindeki potansiyel etkisi de pandemi sırasında dikkatleri üzerine çekmiştir. Coroner bypass uygulanan hastalarda preoperatif ikili antiplatelet tedavisinin (DAPT) kullanımının ve D vitamini düzeylerinin postoperatif sonuçlara etkisini araştırmayı amaçladık. Gereç ve yöntem: Bu retrospektif çalışma, 23 Mart 2020 ile 30 Aralık 2021 tarihleri arasında gerçekleştirildi. Çalışmaya elektif ve acil KABG uygulanan ve ikili antiplatelet tedavi alan 63 hasta dahil edildi, tüm hastalardan ameliyat öncesi d vitamini seviyeleri ölçüldü. Bulgular: altmış üç hastanın 51’i erkek, 12’si kadındı. Ortalama yaş 62.69 ± 8.43 idi. Ameliyat öncesi 15 hasta (%24) Klopidogrel ve Asetilsalisilik asit (ASA), 48 hasta (%76) Ticagrelor ve ASA kullanıyordu. 21 hastaya (%33) pompasız coroner bypass uygulandı. Bir hastada serebrovasküler olay gelişti (%1.6). Ticagrelor ve (ASA) kullanan hastalarda drenaj miktarı anlamLı olarak fazlaydı (p = 0,015). Ortalama D vitamini düzeyi 13,94 ± 5,24 ng/mL idi (3,38 ng/mL-24,99 ng/mL), D vitamini düzeyi kadın hastalarda erkeklere göre anlamLı olarak düşüktü (p = 0,004). Sonuç: İkili antiplatelet tedavisi alan hastalarda korroner bypass cerrahisi eşsiz zorluklar taşımaktadır ve kanama komplikasyonlarını en aza indirmek için dikkatli bir yönetim gerektirir. Ek olarak, ameliyat öncesi yeterli D vitamini düzeylerinin korunması ameliyat sonrası sonuçları iyileştirebilir.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | ALAGHA S, ekim m (2023). Coronary Artery Bypass Surgery in Patients Receiving Dual Antiplatelet Therapy and the Impact of Preoperative Vitamin D Levels During COVID-19 Pandemic: An Observational Single Center Study. , 434 - 438. 10.54005/geneltip.1281015 |
| Chicago | ALAGHA SAMEH,ekim meral Coronary Artery Bypass Surgery in Patients Receiving Dual Antiplatelet Therapy and the Impact of Preoperative Vitamin D Levels During COVID-19 Pandemic: An Observational Single Center Study. (2023): 434 - 438. 10.54005/geneltip.1281015 |
| MLA | ALAGHA SAMEH,ekim meral Coronary Artery Bypass Surgery in Patients Receiving Dual Antiplatelet Therapy and the Impact of Preoperative Vitamin D Levels During COVID-19 Pandemic: An Observational Single Center Study. , 2023, ss.434 - 438. 10.54005/geneltip.1281015 |
| AMA | ALAGHA S,ekim m Coronary Artery Bypass Surgery in Patients Receiving Dual Antiplatelet Therapy and the Impact of Preoperative Vitamin D Levels During COVID-19 Pandemic: An Observational Single Center Study. . 2023; 434 - 438. 10.54005/geneltip.1281015 |
| Vancouver | ALAGHA S,ekim m Coronary Artery Bypass Surgery in Patients Receiving Dual Antiplatelet Therapy and the Impact of Preoperative Vitamin D Levels During COVID-19 Pandemic: An Observational Single Center Study. . 2023; 434 - 438. 10.54005/geneltip.1281015 |
| IEEE | ALAGHA S,ekim m "Coronary Artery Bypass Surgery in Patients Receiving Dual Antiplatelet Therapy and the Impact of Preoperative Vitamin D Levels During COVID-19 Pandemic: An Observational Single Center Study." , ss.434 - 438, 2023. 10.54005/geneltip.1281015 |
| ISNAD | ALAGHA, SAMEH - ekim, meral. "Coronary Artery Bypass Surgery in Patients Receiving Dual Antiplatelet Therapy and the Impact of Preoperative Vitamin D Levels During COVID-19 Pandemic: An Observational Single Center Study". (2023), 434-438. https://doi.org/10.54005/geneltip.1281015 |
| APA | ALAGHA S, ekim m (2023). Coronary Artery Bypass Surgery in Patients Receiving Dual Antiplatelet Therapy and the Impact of Preoperative Vitamin D Levels During COVID-19 Pandemic: An Observational Single Center Study. Genel Tıp Dergisi, 33(4), 434 - 438. 10.54005/geneltip.1281015 |
| Chicago | ALAGHA SAMEH,ekim meral Coronary Artery Bypass Surgery in Patients Receiving Dual Antiplatelet Therapy and the Impact of Preoperative Vitamin D Levels During COVID-19 Pandemic: An Observational Single Center Study. Genel Tıp Dergisi 33, no.4 (2023): 434 - 438. 10.54005/geneltip.1281015 |
| MLA | ALAGHA SAMEH,ekim meral Coronary Artery Bypass Surgery in Patients Receiving Dual Antiplatelet Therapy and the Impact of Preoperative Vitamin D Levels During COVID-19 Pandemic: An Observational Single Center Study. Genel Tıp Dergisi, vol.33, no.4, 2023, ss.434 - 438. 10.54005/geneltip.1281015 |
| AMA | ALAGHA S,ekim m Coronary Artery Bypass Surgery in Patients Receiving Dual Antiplatelet Therapy and the Impact of Preoperative Vitamin D Levels During COVID-19 Pandemic: An Observational Single Center Study. Genel Tıp Dergisi. 2023; 33(4): 434 - 438. 10.54005/geneltip.1281015 |
| Vancouver | ALAGHA S,ekim m Coronary Artery Bypass Surgery in Patients Receiving Dual Antiplatelet Therapy and the Impact of Preoperative Vitamin D Levels During COVID-19 Pandemic: An Observational Single Center Study. Genel Tıp Dergisi. 2023; 33(4): 434 - 438. 10.54005/geneltip.1281015 |
| IEEE | ALAGHA S,ekim m "Coronary Artery Bypass Surgery in Patients Receiving Dual Antiplatelet Therapy and the Impact of Preoperative Vitamin D Levels During COVID-19 Pandemic: An Observational Single Center Study." Genel Tıp Dergisi, 33, ss.434 - 438, 2023. 10.54005/geneltip.1281015 |
| ISNAD | ALAGHA, SAMEH - ekim, meral. "Coronary Artery Bypass Surgery in Patients Receiving Dual Antiplatelet Therapy and the Impact of Preoperative Vitamin D Levels During COVID-19 Pandemic: An Observational Single Center Study". Genel Tıp Dergisi 33/4 (2023), 434-438. https://doi.org/10.54005/geneltip.1281015 |
