Yıl: 2023 Cilt: 30 Sayı: 3 Sayfa Aralığı: 344 - 352 Metin Dili: İngilizce DOI: 10.17343/sdutfd.1256800 İndeks Tarihi: 02-10-2023

INVESTIGATION OF PREDICTIVE FACTORS FOR CLINICAL REMISSION IN RESPONSE TO REPETITIVE TRANSCRANIAL MAGNETIC STIMULATION (RTMS) TREATMENT IN DEPRESSIVE DISORDER

Öz:
Objective It was aimed to examine the socio-demographic and clinical data of patients treated with Repetitive Transcranial Magnetic Stimulation (rTMS) for depressive disorder and to evaluate the relationship of these data with remission response to rTMS treatment. Material and Method The medical records of 120 patients were evaluated retrospectively. Hamilton Depression Scale (HAM-D), Beck Anxiety Scale (BAI), and Richard-Campbell Sleep Scale (RCSQ) scores were analyzed. Results 60% (72/120) of the patients were women and the mean age was 42.80±12.80 years. According to the HAM-D scores (7 and below), 41.4% (46/111) of the patients were in remission at the end of the treatment. In addition, when the pre-treatment and post-treatment scale scores were evaluated, HAM-D scores and BAI scores decreased significantly after treatment (respectively; p<0.001, p<0.001), while RCSQ scores increased significantly after treatment (p<0.001). Binary regression analysis was performed to investigate the predictive factors for remission of depressive symptoms after rTMS treatment. A high HAM-D score at the beginning of the treatment showed a negative predictive relationship with remission (p<0.001), while a decrease in HAM-D scores at the second week of treatment showed a positive predictive relationship with remission (p=0.009). Conclusion We may suggest that rTMS treatment reduces depression and anxiety symptoms and improves sleep quality. In addition, it can be said that the severe depression before the rTMS treatment reduces the likelihood of going into remission, whereas the decrease in the severity of depression observed in the second week of the treatment increases this likelihood.
Anahtar Kelime: Depression Repetitive transcranial magnetic stimulation rTMS Predictive factors Remission

DEPRESİF BOZUKLUKTA TEKRARLAYAN TRANSKRANİYAL MANYETİK STİMÜLASYON (RTMS) TEDAVİSİNE YANIT OLARAK KLİNİK REMİSYON İÇİN PREDİKTİF FAKTÖRLERİN ARAŞTIRILMASI

Öz:
Amaç Depresif bozukluk nedeniyle Tekrarlayan Transkrani- yal Manyetik Stimülasyon (rTMS) tedavisi alan has- taların sosyo-demografik ve klinik verilerinin incelen- mesi ve bu verilerin rTMS tedavisine verilen remisyon yanıtı ile ilişkisinin değerlendirilmesi amaçlandı. Gereç ve Yöntem 120 hastanın tıbbi kayıtları retrospektif olarak değer- lendirildi. Hamilton Depresyon Ölçeği (HAM-D), Beck Anksiyete Ölçeği (BAÖ), Richard-Campbell Uyku Öl- çeği (RCUÖ) puanları analiz edildi. Bulgular Hastaların %60'ı (72/120) kadındı ve yaş ortalaması 42.80±12.80 idi. HAM-D skorlarına göre (7 ve altı) hastaların %41,4'ü (46/111) tedavi sonunda remis- yondaydı. Ayrıca tedavi öncesi ve tedavi sonrası ölçek puanları değerlendirildiğinde, tedavi sonrası HAM-D puanları ve BAÖ puanları anlamlı olarak azalırken (sırasıyla; p<0.001, p<0.001), tedavi sonrası RCUÖ puanları anlamlı olarak arttı (p<0.001). rTMS tedavi- si ile remisyon yanıtını yordayan faktörleri araştırmak üzere ikili regresyon analizi yapıldı. Tedavi başlangı- cında HAM-D skorunun yüksek olması remisyon ile negatif prediktif ilişki gösterirken (p<0.001), tedavinin ikinci haftasında HAM-D skorlarında azalma remisyon ile pozitif prediktif ilişki gösterdi (p=0.009). Sonuç rTMS tedavisinin depresyon ve anksiyete belirtilerini azalttığını ve uyku kalitesini iyileştirdiğini söyleyebili- riz. Ayrıca rTMS tedavisi öncesi şiddetli depresyonun remisyona girme olasılığını azalttığı, tedavinin ikinci haftasında görülen depresyon şiddetindeki azalmanın ise bu olasılığı artırdığı söylenebilir.
Anahtar Kelime: Depresyon Tekrarlayan transkraniyal manyetik stimülasyon rTMS Prediktif faktörler Remisyon

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA ozcelik o, Cinemre B, Erdoğan A, metin ö (2023). INVESTIGATION OF PREDICTIVE FACTORS FOR CLINICAL REMISSION IN RESPONSE TO REPETITIVE TRANSCRANIAL MAGNETIC STIMULATION (RTMS) TREATMENT IN DEPRESSIVE DISORDER. , 344 - 352. 10.17343/sdutfd.1256800
Chicago ozcelik ozgen,Cinemre Buket,Erdoğan Ali,metin özmen INVESTIGATION OF PREDICTIVE FACTORS FOR CLINICAL REMISSION IN RESPONSE TO REPETITIVE TRANSCRANIAL MAGNETIC STIMULATION (RTMS) TREATMENT IN DEPRESSIVE DISORDER. (2023): 344 - 352. 10.17343/sdutfd.1256800
MLA ozcelik ozgen,Cinemre Buket,Erdoğan Ali,metin özmen INVESTIGATION OF PREDICTIVE FACTORS FOR CLINICAL REMISSION IN RESPONSE TO REPETITIVE TRANSCRANIAL MAGNETIC STIMULATION (RTMS) TREATMENT IN DEPRESSIVE DISORDER. , 2023, ss.344 - 352. 10.17343/sdutfd.1256800
AMA ozcelik o,Cinemre B,Erdoğan A,metin ö INVESTIGATION OF PREDICTIVE FACTORS FOR CLINICAL REMISSION IN RESPONSE TO REPETITIVE TRANSCRANIAL MAGNETIC STIMULATION (RTMS) TREATMENT IN DEPRESSIVE DISORDER. . 2023; 344 - 352. 10.17343/sdutfd.1256800
Vancouver ozcelik o,Cinemre B,Erdoğan A,metin ö INVESTIGATION OF PREDICTIVE FACTORS FOR CLINICAL REMISSION IN RESPONSE TO REPETITIVE TRANSCRANIAL MAGNETIC STIMULATION (RTMS) TREATMENT IN DEPRESSIVE DISORDER. . 2023; 344 - 352. 10.17343/sdutfd.1256800
IEEE ozcelik o,Cinemre B,Erdoğan A,metin ö "INVESTIGATION OF PREDICTIVE FACTORS FOR CLINICAL REMISSION IN RESPONSE TO REPETITIVE TRANSCRANIAL MAGNETIC STIMULATION (RTMS) TREATMENT IN DEPRESSIVE DISORDER." , ss.344 - 352, 2023. 10.17343/sdutfd.1256800
ISNAD ozcelik, ozgen vd. "INVESTIGATION OF PREDICTIVE FACTORS FOR CLINICAL REMISSION IN RESPONSE TO REPETITIVE TRANSCRANIAL MAGNETIC STIMULATION (RTMS) TREATMENT IN DEPRESSIVE DISORDER". (2023), 344-352. https://doi.org/10.17343/sdutfd.1256800
APA ozcelik o, Cinemre B, Erdoğan A, metin ö (2023). INVESTIGATION OF PREDICTIVE FACTORS FOR CLINICAL REMISSION IN RESPONSE TO REPETITIVE TRANSCRANIAL MAGNETIC STIMULATION (RTMS) TREATMENT IN DEPRESSIVE DISORDER. Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi, 30(3), 344 - 352. 10.17343/sdutfd.1256800
Chicago ozcelik ozgen,Cinemre Buket,Erdoğan Ali,metin özmen INVESTIGATION OF PREDICTIVE FACTORS FOR CLINICAL REMISSION IN RESPONSE TO REPETITIVE TRANSCRANIAL MAGNETIC STIMULATION (RTMS) TREATMENT IN DEPRESSIVE DISORDER. Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi 30, no.3 (2023): 344 - 352. 10.17343/sdutfd.1256800
MLA ozcelik ozgen,Cinemre Buket,Erdoğan Ali,metin özmen INVESTIGATION OF PREDICTIVE FACTORS FOR CLINICAL REMISSION IN RESPONSE TO REPETITIVE TRANSCRANIAL MAGNETIC STIMULATION (RTMS) TREATMENT IN DEPRESSIVE DISORDER. Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi, vol.30, no.3, 2023, ss.344 - 352. 10.17343/sdutfd.1256800
AMA ozcelik o,Cinemre B,Erdoğan A,metin ö INVESTIGATION OF PREDICTIVE FACTORS FOR CLINICAL REMISSION IN RESPONSE TO REPETITIVE TRANSCRANIAL MAGNETIC STIMULATION (RTMS) TREATMENT IN DEPRESSIVE DISORDER. Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi. 2023; 30(3): 344 - 352. 10.17343/sdutfd.1256800
Vancouver ozcelik o,Cinemre B,Erdoğan A,metin ö INVESTIGATION OF PREDICTIVE FACTORS FOR CLINICAL REMISSION IN RESPONSE TO REPETITIVE TRANSCRANIAL MAGNETIC STIMULATION (RTMS) TREATMENT IN DEPRESSIVE DISORDER. Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi. 2023; 30(3): 344 - 352. 10.17343/sdutfd.1256800
IEEE ozcelik o,Cinemre B,Erdoğan A,metin ö "INVESTIGATION OF PREDICTIVE FACTORS FOR CLINICAL REMISSION IN RESPONSE TO REPETITIVE TRANSCRANIAL MAGNETIC STIMULATION (RTMS) TREATMENT IN DEPRESSIVE DISORDER." Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi, 30, ss.344 - 352, 2023. 10.17343/sdutfd.1256800
ISNAD ozcelik, ozgen vd. "INVESTIGATION OF PREDICTIVE FACTORS FOR CLINICAL REMISSION IN RESPONSE TO REPETITIVE TRANSCRANIAL MAGNETIC STIMULATION (RTMS) TREATMENT IN DEPRESSIVE DISORDER". Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi 30/3 (2023), 344-352. https://doi.org/10.17343/sdutfd.1256800