Although COVID-19 has emerged as a disease affecting the respiratory system, increasing data show it is not limited to the respiratory system but also affects both the central and peripheral nervous systems. Since it affects many people and has been declared a pandemic, information about the course of the disease and the treatment plan during and/or after COVID-19 in patients with chronic neurological disease is becoming increasingly important. A 42-year-old male patient who was hospitalized in the infectious diseases service because of being COVID-19 positive was evaluated with difficulty breathing and swallowing and weakness in four extremities. On neurological examination, muscle strength was 3/5 in all four extremities according to the Medical Research Council (MRC) scale, and there was widespread hypoesthesia in all four extremities. Deep tendon reflexes were completely absent. The first complaints of our patient started six years ago, and the diagnosis of CIDP was made two years after the first complaint, with typical clinical features and electrophysiological findings. In this case report, we share a patient with COVID-19 and chronic inflammatory demyelinating polyneuropathy (CIDP), and we aim to report the clinical worsening of CIDP with COVID-19.