The Synthesis of a Controlled Release System Based on MMT Added IPN Type Hydrogels
Yıl: 2023 Cilt: 11 Sayı: 3 Sayfa Aralığı: 837 - 849 Metin Dili: İngilizce DOI: 10.29109/gujsc.1342653 İndeks Tarihi: 04-10-2023
The Synthesis of a Controlled Release System Based on MMT Added IPN Type Hydrogels
Öz: The purpose of our study is to develop a controlled Naproxen releasing system for anti-inflammatory, analgesic treatments. Interpenetrating polymer network (IPN) type of hydrogels were obtained by using natural polymers alginate and gelatin. The hydrogels were prepared by combining Alginate and Gelatin in the presence of Glutaraldehyde as crosslinker of gelatin. Montmorillonite (MMT) clay was used as a nano-dimensioned and layered dopant. The prepared hydrogels were characterized via hydrogel formation, swelling/degradation measurements, Fourier Transform Infrared Spectroscopy (FT-IR), and Scanning Electron Microscopy (SEM) analysis. Swelling tests presented that the presence of MMT in the polymer network decreases the swelling. From the SEM micrographs, it can be seen that MMT added hydrogel has smaller and more pore than the other. The release studies of Naproxen were maintained in Britton-Robinson Buffer (BRB) solution (pH=7.4) and at 37°C. It is observed that the swelling profiles of the hydrogels were compatible with the releasing behaviors. The release kinetics of Naproxen are match the Fickian diffusion.
Anahtar Kelime: MMT Katkılı IPN Tipi Hidrojel Temelli Kontrollü Salım Sisteminin Sentezi
Öz: Çalışmamızın amacı antiinflamatuar, analjezik tedaviler için kontrollü bir Naproksen salınım sistemi geliştirmektir. İç içe geçmiş polimer ağı (IPN) tipi hidrojeller, doğal polimerler aljinat ve jelatin kullanılarak elde edildi. Hidrojeller, aljinat ve jelatinin, jelatinin çapraz bağlayıcısı olarak glutaraldehit varlığında birleştirilmesiyle hazırlandı. Nano boyutlu ve katmanlı katkı maddesi olarak Montmorillonit (MMT) kili kullanıldı. Hazırlanan hidrojeller, hidrojel oluşumu, şişme/bozulma ölçümleri, Fourier Dönüşümü Kızılötesi Spektroskopisi (FT-IR) ve Taramalı Elektron Mikroskobu (SEM) analizi ile karakterize edildi. Şişme testleri, polimer ağındaki MMT varlığının şişmeyi azalttığını ortaya koydu. SEM mikrograflarından MMT katkılı hidrojelin diğerine göre daha küçük ve daha fazla gözeneklere sahip olduğu görülmektedir. Naproksen'in salım çalışmaları Britton-Robinson Tampon (BRB) çözeltisinde (pH=7,4) ve 37°C'de sürdürüldü. Hidrojellerin şişme profillerinin salım davranışlarıyla uyumlu olduğu gözlendi. Naproksen'in salım kinetiği Fickian difüzyonuyla eşleşmektedir.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | SEVER E, pulat m (2023). The Synthesis of a Controlled Release System Based on MMT Added IPN Type Hydrogels. , 837 - 849. 10.29109/gujsc.1342653 |
| Chicago | SEVER Evrim,pulat mehlika The Synthesis of a Controlled Release System Based on MMT Added IPN Type Hydrogels. (2023): 837 - 849. 10.29109/gujsc.1342653 |
| MLA | SEVER Evrim,pulat mehlika The Synthesis of a Controlled Release System Based on MMT Added IPN Type Hydrogels. , 2023, ss.837 - 849. 10.29109/gujsc.1342653 |
| AMA | SEVER E,pulat m The Synthesis of a Controlled Release System Based on MMT Added IPN Type Hydrogels. . 2023; 837 - 849. 10.29109/gujsc.1342653 |
| Vancouver | SEVER E,pulat m The Synthesis of a Controlled Release System Based on MMT Added IPN Type Hydrogels. . 2023; 837 - 849. 10.29109/gujsc.1342653 |
| IEEE | SEVER E,pulat m "The Synthesis of a Controlled Release System Based on MMT Added IPN Type Hydrogels." , ss.837 - 849, 2023. 10.29109/gujsc.1342653 |
| ISNAD | SEVER, Evrim - pulat, mehlika. "The Synthesis of a Controlled Release System Based on MMT Added IPN Type Hydrogels". (2023), 837-849. https://doi.org/10.29109/gujsc.1342653 |
| APA | SEVER E, pulat m (2023). The Synthesis of a Controlled Release System Based on MMT Added IPN Type Hydrogels. Gazi Üniversitesi Fen Bilimleri Dergisi Part C: Tasarım ve Teknoloji, 11(3), 837 - 849. 10.29109/gujsc.1342653 |
| Chicago | SEVER Evrim,pulat mehlika The Synthesis of a Controlled Release System Based on MMT Added IPN Type Hydrogels. Gazi Üniversitesi Fen Bilimleri Dergisi Part C: Tasarım ve Teknoloji 11, no.3 (2023): 837 - 849. 10.29109/gujsc.1342653 |
| MLA | SEVER Evrim,pulat mehlika The Synthesis of a Controlled Release System Based on MMT Added IPN Type Hydrogels. Gazi Üniversitesi Fen Bilimleri Dergisi Part C: Tasarım ve Teknoloji, vol.11, no.3, 2023, ss.837 - 849. 10.29109/gujsc.1342653 |
| AMA | SEVER E,pulat m The Synthesis of a Controlled Release System Based on MMT Added IPN Type Hydrogels. Gazi Üniversitesi Fen Bilimleri Dergisi Part C: Tasarım ve Teknoloji. 2023; 11(3): 837 - 849. 10.29109/gujsc.1342653 |
| Vancouver | SEVER E,pulat m The Synthesis of a Controlled Release System Based on MMT Added IPN Type Hydrogels. Gazi Üniversitesi Fen Bilimleri Dergisi Part C: Tasarım ve Teknoloji. 2023; 11(3): 837 - 849. 10.29109/gujsc.1342653 |
| IEEE | SEVER E,pulat m "The Synthesis of a Controlled Release System Based on MMT Added IPN Type Hydrogels." Gazi Üniversitesi Fen Bilimleri Dergisi Part C: Tasarım ve Teknoloji, 11, ss.837 - 849, 2023. 10.29109/gujsc.1342653 |
| ISNAD | SEVER, Evrim - pulat, mehlika. "The Synthesis of a Controlled Release System Based on MMT Added IPN Type Hydrogels". Gazi Üniversitesi Fen Bilimleri Dergisi Part C: Tasarım ve Teknoloji 11/3 (2023), 837-849. https://doi.org/10.29109/gujsc.1342653 |
