EZH2 expression in the skin of developing human fetuses and adults: a comparative study
Yıl: 2023 Cilt: 48 Sayı: 3 Sayfa Aralığı: 1081 - 1089 Metin Dili: İngilizce DOI: 10.17826/cumj.1321745 İndeks Tarihi: 04-10-2023
EZH2 expression in the skin of developing human fetuses and adults: a comparative study
Öz: Purpose: In animals, the appropriate levels of Enhancer of zeste homolog 2 (EZH2), a well-established epigenetic regulator, are essential for the embryonic development of skin and appendages. We aimed to explore the EZH2 expression patterns in the skin of human fetuses and compare them with adults. Materials and Methods: We performed EZH2 immunohistochemical staining in skin samples from the scalp region of 67 fetuses and from the farthest surgical margin of the lip wedge resection, where no lesions were found, of 23 adults. EZH2 scores were evaluated according to the literature. Results: Epidermal (r = − 0.528), dermal (rs = − 0.509), and hair follicle (r = − 0.576) EZH2 scores were inversely correlated with gestational age. Epidermal and hair follicle EZH2 scores were significantly higher in adults compared to fetuses. There were significant and positive correlations between epidermal, dermal, and hair follicle EZH2 scores among fetuses and adults. Conclusion: Lower levels of EZH2 may be necessary for final cutaneous differentiation and maturation before birth. Our findings may have a therapeutic impact on cutaneous disorders with differentiation defects, chronic wounds, and alopecias.
Anahtar Kelime: Gelişmekte olan insan fetüslerinin ve yetişkinlerin derisinde EZH2 ekspresyonu: karşılaştırmalı bir çalışma
Öz: Amaç: Epigenetic düzenleyici olan Enhancer of zeste homolog 2 (EZH2), hayvanlarda deri ve eklerinin embriyonik gelişimi için gereklidir. Bu çalışmada, insan fetüslerinin deri örneklerinde EZH2 ekspresyon paternlerini, erişkinler ile karşılaştırmalı olarak araştırmayı amaçladık. Gereç ve Yöntem: Altmış yedi fetüsün skalp bölgesinden ve 23 yetişkinin dudak wedge rezeksiyonunun en uzak cerrahi sınırından alınan, herhangi bir lezyon bulunmayan, deri örneklerinde EZH2 ile immünohistokimyasal boyama uygulandı. EZH2 skorları literatüre göre değerlendirildi. Bulgular: Epidermal (r = - 0,528), dermal (rs = - 0,509) ve kıl folikülü (r = - 0,576) EZH2 skorları gebelik yaşı ile ters orantılıydı. Epidermal ve kıl folikülü EZH2 skorları erişkinlerde fetüslere göre anlamlı olarak daha yüksekti. Hem fetüs hem de erişkin dokularda epidermal, dermal ve kıl folikülü EZH2 skorları arasında anlamlı ve pozitif korelasyonlar saptandı. Sonuç: Doğumdan önce nihai kutanöz farklılaşma ve olgunlaşma için daha düşük EZH2 seviyeleri gerekli olabilir. Bulgularımız, farklılaşma kusurları izlenen deri hastalıkları, kronik yaralar ve alopesiler üzerinde terapötik bir etkiye sahip olabilir.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | zorlu o, karabağ s, Erdogan K, Kuşsever E, Özer Aslan İ (2023). EZH2 expression in the skin of developing human fetuses and adults: a comparative study. , 1081 - 1089. 10.17826/cumj.1321745 |
| Chicago | zorlu ozge,karabağ sevil,Erdogan Kivilcim,Kuşsever Evin,Özer Aslan İlke EZH2 expression in the skin of developing human fetuses and adults: a comparative study. (2023): 1081 - 1089. 10.17826/cumj.1321745 |
| MLA | zorlu ozge,karabağ sevil,Erdogan Kivilcim,Kuşsever Evin,Özer Aslan İlke EZH2 expression in the skin of developing human fetuses and adults: a comparative study. , 2023, ss.1081 - 1089. 10.17826/cumj.1321745 |
| AMA | zorlu o,karabağ s,Erdogan K,Kuşsever E,Özer Aslan İ EZH2 expression in the skin of developing human fetuses and adults: a comparative study. . 2023; 1081 - 1089. 10.17826/cumj.1321745 |
| Vancouver | zorlu o,karabağ s,Erdogan K,Kuşsever E,Özer Aslan İ EZH2 expression in the skin of developing human fetuses and adults: a comparative study. . 2023; 1081 - 1089. 10.17826/cumj.1321745 |
| IEEE | zorlu o,karabağ s,Erdogan K,Kuşsever E,Özer Aslan İ "EZH2 expression in the skin of developing human fetuses and adults: a comparative study." , ss.1081 - 1089, 2023. 10.17826/cumj.1321745 |
| ISNAD | zorlu, ozge vd. "EZH2 expression in the skin of developing human fetuses and adults: a comparative study". (2023), 1081-1089. https://doi.org/10.17826/cumj.1321745 |
| APA | zorlu o, karabağ s, Erdogan K, Kuşsever E, Özer Aslan İ (2023). EZH2 expression in the skin of developing human fetuses and adults: a comparative study. Cukurova Medical Journal, 48(3), 1081 - 1089. 10.17826/cumj.1321745 |
| Chicago | zorlu ozge,karabağ sevil,Erdogan Kivilcim,Kuşsever Evin,Özer Aslan İlke EZH2 expression in the skin of developing human fetuses and adults: a comparative study. Cukurova Medical Journal 48, no.3 (2023): 1081 - 1089. 10.17826/cumj.1321745 |
| MLA | zorlu ozge,karabağ sevil,Erdogan Kivilcim,Kuşsever Evin,Özer Aslan İlke EZH2 expression in the skin of developing human fetuses and adults: a comparative study. Cukurova Medical Journal, vol.48, no.3, 2023, ss.1081 - 1089. 10.17826/cumj.1321745 |
| AMA | zorlu o,karabağ s,Erdogan K,Kuşsever E,Özer Aslan İ EZH2 expression in the skin of developing human fetuses and adults: a comparative study. Cukurova Medical Journal. 2023; 48(3): 1081 - 1089. 10.17826/cumj.1321745 |
| Vancouver | zorlu o,karabağ s,Erdogan K,Kuşsever E,Özer Aslan İ EZH2 expression in the skin of developing human fetuses and adults: a comparative study. Cukurova Medical Journal. 2023; 48(3): 1081 - 1089. 10.17826/cumj.1321745 |
| IEEE | zorlu o,karabağ s,Erdogan K,Kuşsever E,Özer Aslan İ "EZH2 expression in the skin of developing human fetuses and adults: a comparative study." Cukurova Medical Journal, 48, ss.1081 - 1089, 2023. 10.17826/cumj.1321745 |
| ISNAD | zorlu, ozge vd. "EZH2 expression in the skin of developing human fetuses and adults: a comparative study". Cukurova Medical Journal 48/3 (2023), 1081-1089. https://doi.org/10.17826/cumj.1321745 |
