The effect of nebulized magnesium sulfate on asthma attacks in the children
Yıl: 2023 Cilt: 28 Sayı: 3 Sayfa Aralığı: 259 - 265 Metin Dili: İngilizce DOI: 10.21673/anadoluklin.1288549 İndeks Tarihi: 05-10-2023
The effect of nebulized magnesium sulfate on asthma attacks in the children
Öz: Aim: This study aimed to determine the effect of adding nebulized magnesium sulfate to standard treatment in children with moderate to severe acute asthma attacks. Methods: Pediatric patients admitted to the emergency department with moderate to severe asthma attacks were included in the study. The patients were divided into two groups. Group S received standard treatment, while Group M received nebulized magnesium sulfate in addition to standard therapy. Results: A total of 129 patients were included in the study, 86 (66.7%) were male, and the median (minimum-maximum) age was 4 (2-8) years. When groups were compared, oxygen saturation at hour 1 was higher (p=0.024), and the PRAM (preschool respiratory assessment measure) scores at the 4th hour were lower (p=0.008) in the group that received magnesium sulfate. The groups had no differences regarding any of the other parameters at the 1st and 4th hours (p>0.05). Conclusion: Adding nebulized magnesium sulfate to standard treatment in children with asthma attacks improves oxygen saturation faster and positively affects PRAM score at hour 4.
Anahtar Kelime: Nebulize magnezyum sülfatın çocuklarda astım atakları üzerine etkisi
Öz: Amaç: Bu çalışmanın amacı orta ila şiddetli akut astım atakları olan çocuklarda standart tedaviye nebülize magnezyum sülfat eklenmesinin etkisini belirlemektir. Yöntem: Acil servise orta ve şiddetli astım atağı ile başvuran pediatrik hastalar çalışmaya dâhil edildi. Hastalar iki gruba ayrıldı. Grup S standart tedavi alırken, Grup M standart tedaviye ek olarak nebulize magnezyum sülfat aldı. Bulgular: Çalışmaya toplam 129 hasta dâhil edildi, 86’sı (%66,7) erkekti ve ortanca yaş (minimum-maksimum) 4(2-8) idi. Gruplar karşılaştırıldığında magnezyum sülfat verilen grupta 1. saat oksijen satürasyonu daha yüksek (p=0,024), 4. saat PRAM skoru (PRAM: Okul öncesi solunum değerlendirme ölçüsü) daha düşüktü (p=0,008). Diğer parametrelerde gruplar arasında 1. ve 4. saatte fark yoktu (p>0,05). Sonuç: Astım atağı olan çocuklarda standart tedaviye nebülize magnezyum sülfat eklenmesi oksijen satürasyonunu daha hızlı iyileştirmekte ve 4. saatteki PRAM skorunu olumlu yönde etkilemektedir.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
- 1. Daengsuwan T, Watanatham S. A comparative pilot study of the efficacy and safety of nebulized magnesium sulfate and intravenous magnesium sulfate in children with severe acute asthma. Asian Pac J Allergy Immunol. 2017;35(2):108-12.
- 2. Mohammed S, Goodacre S. Intravenous and nebulised magnesium sulphate for acute asthma: systematic review and meta-analysis. Emerg Med J. 2007;24(12):823-30.
- 3. Knightly R, Milan SJ, Hughes R, et al. Inhaled magne- sium sulfate in the treatment of acute asthma. Cochrane Database Syst Rev. 2017;11(11):CD003898.
- 4. GIF Asthma. Global strategy for asthma management and prevention. Global Initiative for Asthma; 2015. Ac- cess date: 08.10.2022. Available from: https://ginasthma. org/wp-content/uploads/2016/01/GINA_Report_2015_ Aug11-1.pdf.
- 5. Goodacre S, Cohen J, Bradburn M, et al. Intravenous or nebulised magnesium sulphate versus standard therapy for severe acute asthma (3Mg trial): a double- blind, randomised controlled trial. Lancet Respir Med. 2013;1(4):293-300.
- 6. Singh AK, Gaur S, Kumar R. A randomized controlled trial of intravenous magnesium sulphate as an adjunct to standard therapy in acute severe asthma. Iran J. Allergy. Asthma Immunol. 2008;7(4):221-9.
- 7. Kew KM, Kirtchuk L, Michell CI. Intravenous magne- sium sulfate for treating adults with acute asthma in the emergency department. Cochrane Database Syst Rev. 2014;(5):CD010909.
- 8. Schulz KF, Altman DG, Moher D; CONSORT Group. CONSORT 2010 statement: updated guidelines for re- porting parallel group randomised trials. Int J Surg 2011;9:672–7.
- 9. Chalut DS, Ducharme FM, Davis GM. The Preschool Re- spiratory Assessment Measure (PRAM): a responsive in- dex of acute asthma severity. J Pediatr. 2000;137(6):762- 8.
- 10. Classen H; Jacob R; Schimatschek H. Interactions of Magnesium with Direct and Indirect Acting Sympatho- mimetic Amines. Magnesium. 1987;9:80-7.
- 11. Middleton E Jr. Antiasthmatic drug therapy and calci- um ions: review of pathogenesis and role of calcium. J Pharm Sci. 1980;69(2):243-51.
- 12. Hill J, Britton J. Dose-response relationship and time- course of the effect of inhaled magnesium sulphate on airflow in normal and asthmatic subjects. Br J Clin Phar- macol. 1995;40(6):539-44.
- 13. Iseri LT, French JH. Magnesium: nature’s physiologic cal- cium blocker. Am Heart J. 1984;108(1):188-93.
- 14. Nannini LJ Jr, Pendino JC, Corna RA, Mannarino S, Quispe R. Magnesium sulfate as a vehicle for nebulized salbutamol in acute asthma. Am J Med. 2000;108(3):193- 7.
- 15. Mahajan P, Haritos D, Rosenberg N, Thomas R. Com- parison of nebulized magnesium sulfate plus albuterol to nebulized albuterol plus saline in children with acute exacerbations of mild to moderate asthma. J Emerg Med. 2004;27(1):21-5.
- 16. Aggarwal P, Sharad S, Handa R, Dwiwedi SN, Irshad M. Comparison of nebulised magnesium sulphate and sal- butamol combined with salbutamol alone in the treat- ment of acute bronchial asthma: a randomised study. Emerg Med J. 2006;23(5):358-62.
- 17. National Institutes of Health. Global strategy for asthma management and prevention [updated 2005]. Access date: 25.10. 2022. Available from: www.ginasthma.org.
- 18. Ducharme FM, Davis GM. Measurement of respira- tory resistance in the emergency department: feasi- bility in young children with acute asthma. Chest. 1997;111(6):1519-25.
- 19. Gorelick MH, Stevens MW, Schultz TR, Scribano PV. Performance of a novel clinical score, the Pediatric Asthma Severity Score (PASS), in the evaluation of acute asthma. Acad Emerg Med. 2004;11(1):10-8.
- 20. Canny GJ, Reisman J, Healy R, et al. Acute asthma: ob- servations regarding the management of a pediatric emergency room. Pediatrics. 1989;83(4):507-12.
- 21. Birken CS, Parkin PC, Macarthur C. Asthma sever- ity scores for preschoolers displayed weaknesses in re- liability, validity, and responsiveness. J Clin Epidemiol. 2004;57(11):1177-81.
| APA | aslan m, KARABAĞ H, topal e, Gozukara Bag H, kaplan f (2023). The effect of nebulized magnesium sulfate on asthma attacks in the children. , 259 - 265. 10.21673/anadoluklin.1288549 |
| Chicago | aslan mehmet,KARABAĞ HİLAL,topal erdem,Gozukara Bag Harika Gozde,kaplan fatih The effect of nebulized magnesium sulfate on asthma attacks in the children. (2023): 259 - 265. 10.21673/anadoluklin.1288549 |
| MLA | aslan mehmet,KARABAĞ HİLAL,topal erdem,Gozukara Bag Harika Gozde,kaplan fatih The effect of nebulized magnesium sulfate on asthma attacks in the children. , 2023, ss.259 - 265. 10.21673/anadoluklin.1288549 |
| AMA | aslan m,KARABAĞ H,topal e,Gozukara Bag H,kaplan f The effect of nebulized magnesium sulfate on asthma attacks in the children. . 2023; 259 - 265. 10.21673/anadoluklin.1288549 |
| Vancouver | aslan m,KARABAĞ H,topal e,Gozukara Bag H,kaplan f The effect of nebulized magnesium sulfate on asthma attacks in the children. . 2023; 259 - 265. 10.21673/anadoluklin.1288549 |
| IEEE | aslan m,KARABAĞ H,topal e,Gozukara Bag H,kaplan f "The effect of nebulized magnesium sulfate on asthma attacks in the children." , ss.259 - 265, 2023. 10.21673/anadoluklin.1288549 |
| ISNAD | aslan, mehmet vd. "The effect of nebulized magnesium sulfate on asthma attacks in the children". (2023), 259-265. https://doi.org/10.21673/anadoluklin.1288549 |
| APA | aslan m, KARABAĞ H, topal e, Gozukara Bag H, kaplan f (2023). The effect of nebulized magnesium sulfate on asthma attacks in the children. ANADOLU KLİNİĞİ TIP BİLİMLERİ DERGİSİ, 28(3), 259 - 265. 10.21673/anadoluklin.1288549 |
| Chicago | aslan mehmet,KARABAĞ HİLAL,topal erdem,Gozukara Bag Harika Gozde,kaplan fatih The effect of nebulized magnesium sulfate on asthma attacks in the children. ANADOLU KLİNİĞİ TIP BİLİMLERİ DERGİSİ 28, no.3 (2023): 259 - 265. 10.21673/anadoluklin.1288549 |
| MLA | aslan mehmet,KARABAĞ HİLAL,topal erdem,Gozukara Bag Harika Gozde,kaplan fatih The effect of nebulized magnesium sulfate on asthma attacks in the children. ANADOLU KLİNİĞİ TIP BİLİMLERİ DERGİSİ, vol.28, no.3, 2023, ss.259 - 265. 10.21673/anadoluklin.1288549 |
| AMA | aslan m,KARABAĞ H,topal e,Gozukara Bag H,kaplan f The effect of nebulized magnesium sulfate on asthma attacks in the children. ANADOLU KLİNİĞİ TIP BİLİMLERİ DERGİSİ. 2023; 28(3): 259 - 265. 10.21673/anadoluklin.1288549 |
| Vancouver | aslan m,KARABAĞ H,topal e,Gozukara Bag H,kaplan f The effect of nebulized magnesium sulfate on asthma attacks in the children. ANADOLU KLİNİĞİ TIP BİLİMLERİ DERGİSİ. 2023; 28(3): 259 - 265. 10.21673/anadoluklin.1288549 |
| IEEE | aslan m,KARABAĞ H,topal e,Gozukara Bag H,kaplan f "The effect of nebulized magnesium sulfate on asthma attacks in the children." ANADOLU KLİNİĞİ TIP BİLİMLERİ DERGİSİ, 28, ss.259 - 265, 2023. 10.21673/anadoluklin.1288549 |
| ISNAD | aslan, mehmet vd. "The effect of nebulized magnesium sulfate on asthma attacks in the children". ANADOLU KLİNİĞİ TIP BİLİMLERİ DERGİSİ 28/3 (2023), 259-265. https://doi.org/10.21673/anadoluklin.1288549 |
