Determination of Progesterone in Pharmaceutical Preparations by UV, First-order Derivative Spectrophotometry and Gas Chromatography

Yılmaz, Bilal; Albayrak, Mevlut; KADIOGLU, Yucel

doi:10.17776/csj.1303270

Determination of Progesterone in Pharmaceutical Preparations by UV, First-order Derivative Spectrophotometry and Gas Chromatography

Bilal YILMAZ, (Atatürk Üniversitesi, Eczacılık Fakültesi, Analitik Kimya Anabilim Dalı, Erzurum, Türkiye)

Mevlüt ALBAYRAK, (Atatürk Üniversitesi, Sağlık Hizmetleri Meslek Yüksekokulu, Tıbbi Laboratuvar Teknikleri Bölümü, Erzurum, Türkiye)

Yücel KADIOĞLU (Atatürk Üniversitesi, Eczacılık Fakültesi, Analitik Kimya Anabilim Dalı, Erzurum, Türkiye)

Cumhuriyet Science Journal

5 1

Yıl: 2023 Cilt: 44 Sayı: 3 Sayfa Aralığı: 456 - 463 Metin Dili: İngilizce DOI: 10.17776/csj.1303270 İndeks Tarihi: 05-10-2023

Determination of Progesterone in Pharmaceutical Preparations by UV, First-order Derivative Spectrophotometry and Gas Chromatography

Öz:

The determination of progesterone in pure and capsule form was accomplished in this work using new, simple and quick procedures by UV spectrophotometry, first-order derivative spectrophotometry and gas chromatography. To increase the sensitivity of the suggested methods, it was necessary to optimize the solvent system, the detection wavelength, and the chromatographic conditions. The linear regression equations for the UV spectrophotometry, first-order derivative spectrophotometry and gas chromatography were y=0.0536x+0.0002, y=0.1362x+0.0014, and y=1.8217x-1.239, respectively, as determined by the least square regression approach. Under the chosen experimental conditions, no interference was found. The suggested methods are extremely accurate and precise. When the suggested methods' findings were compared to those of two published reference methods, there was statistically no discernible difference. Therefore, the methods are applicable to the measurement of progesterone in pharmaceutical formulations.

Anahtar Kelime: Progesterone Spectrophotometry Gas chromatography Validation.

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Yılmaz B, Albayrak M, KADIOGLU Y (2023). Determination of Progesterone in Pharmaceutical Preparations by UV, First-order Derivative Spectrophotometry and Gas Chromatography. , 456 - 463. 10.17776/csj.1303270
Chicago	Yılmaz Bilal,Albayrak Mevlut,KADIOGLU Yucel Determination of Progesterone in Pharmaceutical Preparations by UV, First-order Derivative Spectrophotometry and Gas Chromatography. (2023): 456 - 463. 10.17776/csj.1303270
MLA	Yılmaz Bilal,Albayrak Mevlut,KADIOGLU Yucel Determination of Progesterone in Pharmaceutical Preparations by UV, First-order Derivative Spectrophotometry and Gas Chromatography. , 2023, ss.456 - 463. 10.17776/csj.1303270
AMA	Yılmaz B,Albayrak M,KADIOGLU Y Determination of Progesterone in Pharmaceutical Preparations by UV, First-order Derivative Spectrophotometry and Gas Chromatography. . 2023; 456 - 463. 10.17776/csj.1303270
Vancouver	Yılmaz B,Albayrak M,KADIOGLU Y Determination of Progesterone in Pharmaceutical Preparations by UV, First-order Derivative Spectrophotometry and Gas Chromatography. . 2023; 456 - 463. 10.17776/csj.1303270
IEEE	Yılmaz B,Albayrak M,KADIOGLU Y "Determination of Progesterone in Pharmaceutical Preparations by UV, First-order Derivative Spectrophotometry and Gas Chromatography." , ss.456 - 463, 2023. 10.17776/csj.1303270
ISNAD	Yılmaz, Bilal vd. "Determination of Progesterone in Pharmaceutical Preparations by UV, First-order Derivative Spectrophotometry and Gas Chromatography". (2023), 456-463. https://doi.org/10.17776/csj.1303270

APA	Yılmaz B, Albayrak M, KADIOGLU Y (2023). Determination of Progesterone in Pharmaceutical Preparations by UV, First-order Derivative Spectrophotometry and Gas Chromatography. Cumhuriyet Science Journal, 44(3), 456 - 463. 10.17776/csj.1303270
Chicago	Yılmaz Bilal,Albayrak Mevlut,KADIOGLU Yucel Determination of Progesterone in Pharmaceutical Preparations by UV, First-order Derivative Spectrophotometry and Gas Chromatography. Cumhuriyet Science Journal 44, no.3 (2023): 456 - 463. 10.17776/csj.1303270
MLA	Yılmaz Bilal,Albayrak Mevlut,KADIOGLU Yucel Determination of Progesterone in Pharmaceutical Preparations by UV, First-order Derivative Spectrophotometry and Gas Chromatography. Cumhuriyet Science Journal, vol.44, no.3, 2023, ss.456 - 463. 10.17776/csj.1303270
AMA	Yılmaz B,Albayrak M,KADIOGLU Y Determination of Progesterone in Pharmaceutical Preparations by UV, First-order Derivative Spectrophotometry and Gas Chromatography. Cumhuriyet Science Journal. 2023; 44(3): 456 - 463. 10.17776/csj.1303270
Vancouver	Yılmaz B,Albayrak M,KADIOGLU Y Determination of Progesterone in Pharmaceutical Preparations by UV, First-order Derivative Spectrophotometry and Gas Chromatography. Cumhuriyet Science Journal. 2023; 44(3): 456 - 463. 10.17776/csj.1303270
IEEE	Yılmaz B,Albayrak M,KADIOGLU Y "Determination of Progesterone in Pharmaceutical Preparations by UV, First-order Derivative Spectrophotometry and Gas Chromatography." Cumhuriyet Science Journal, 44, ss.456 - 463, 2023. 10.17776/csj.1303270
ISNAD	Yılmaz, Bilal vd. "Determination of Progesterone in Pharmaceutical Preparations by UV, First-order Derivative Spectrophotometry and Gas Chromatography". Cumhuriyet Science Journal 44/3 (2023), 456-463. https://doi.org/10.17776/csj.1303270