Investigation of Chloride Anion Binding Properties of Glipizide Drug
Yıl: 2023 Cilt: 10 Sayı: 3 Sayfa Aralığı: 262 - 277 Metin Dili: İngilizce DOI: 10.54287/gujsa.1281246 İndeks Tarihi: 05-10-2023
Investigation of Chloride Anion Binding Properties of Glipizide Drug
Öz: This study addresses the anion binding property of Glipizide (GLP), an oral antidiabetic a second-generation drug member of the sulphonylurea (SU) family. GLP effectively interacts with Cl- anion according to 1H-NMR spectroscopic titrations of successive tetrabutylammonium chloride (TBACl) in deuterated chloroform (CDCl3) and dimethyl sulfoxide (d6-DMSO). Upon the addition of TBACl, the change in chemical shift was observed for both N-H protons of SU in CDCl3, whereas it causes a difference in the shift of only one of N-H proton in SU in d6-DMSO. In addition, the data obtained from 1H-NMR spectroscopic titrations was analyzed by DynaFit program to calculate the binding constant (Ka) value between GLP and Cl- anion. It was found that GLP binds Cl- anion in CDCl3 with higher affinity (Ka=77.37 M-1, Fitplot for N-Hh proton at δ=6.47 ppm) than in d6-DMSO (Ka=38.53 M-1, Fitplot for N-Hh proton at δ=6.32 ppm).
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | Mert S (2023). Investigation of Chloride Anion Binding Properties of Glipizide Drug. , 262 - 277. 10.54287/gujsa.1281246 |
| Chicago | Mert Serap Investigation of Chloride Anion Binding Properties of Glipizide Drug. (2023): 262 - 277. 10.54287/gujsa.1281246 |
| MLA | Mert Serap Investigation of Chloride Anion Binding Properties of Glipizide Drug. , 2023, ss.262 - 277. 10.54287/gujsa.1281246 |
| AMA | Mert S Investigation of Chloride Anion Binding Properties of Glipizide Drug. . 2023; 262 - 277. 10.54287/gujsa.1281246 |
| Vancouver | Mert S Investigation of Chloride Anion Binding Properties of Glipizide Drug. . 2023; 262 - 277. 10.54287/gujsa.1281246 |
| IEEE | Mert S "Investigation of Chloride Anion Binding Properties of Glipizide Drug." , ss.262 - 277, 2023. 10.54287/gujsa.1281246 |
| ISNAD | Mert, Serap. "Investigation of Chloride Anion Binding Properties of Glipizide Drug". (2023), 262-277. https://doi.org/10.54287/gujsa.1281246 |
| APA | Mert S (2023). Investigation of Chloride Anion Binding Properties of Glipizide Drug. Gazi University Journal of Science Part A: Engineering and Innovation, 10(3), 262 - 277. 10.54287/gujsa.1281246 |
| Chicago | Mert Serap Investigation of Chloride Anion Binding Properties of Glipizide Drug. Gazi University Journal of Science Part A: Engineering and Innovation 10, no.3 (2023): 262 - 277. 10.54287/gujsa.1281246 |
| MLA | Mert Serap Investigation of Chloride Anion Binding Properties of Glipizide Drug. Gazi University Journal of Science Part A: Engineering and Innovation, vol.10, no.3, 2023, ss.262 - 277. 10.54287/gujsa.1281246 |
| AMA | Mert S Investigation of Chloride Anion Binding Properties of Glipizide Drug. Gazi University Journal of Science Part A: Engineering and Innovation. 2023; 10(3): 262 - 277. 10.54287/gujsa.1281246 |
| Vancouver | Mert S Investigation of Chloride Anion Binding Properties of Glipizide Drug. Gazi University Journal of Science Part A: Engineering and Innovation. 2023; 10(3): 262 - 277. 10.54287/gujsa.1281246 |
| IEEE | Mert S "Investigation of Chloride Anion Binding Properties of Glipizide Drug." Gazi University Journal of Science Part A: Engineering and Innovation, 10, ss.262 - 277, 2023. 10.54287/gujsa.1281246 |
| ISNAD | Mert, Serap. "Investigation of Chloride Anion Binding Properties of Glipizide Drug". Gazi University Journal of Science Part A: Engineering and Innovation 10/3 (2023), 262-277. https://doi.org/10.54287/gujsa.1281246 |
