Parkinson modelinde borik asit ve kuersetin kombinasyonunun oksidatif stres/bilişsel fonksiyon üzerine etkisi

Elif YAVUZ, (Üsküdar Üniversitesi, Mühendislik ve Doğa Bilimleri Fakültesi, Moleküler Biyoloji ve Genetik Bölümü, İstanbul, 34662, Türkiye)
Güven ÇEVİK, (Üsküdar Üniversitesi, Mühendislik ve Doğa Bilimleri Fakültesi, Moleküler Biyoloji ve Genetik Bölümü, İstanbul, 34662, Türkiye)
Burcu ÇEVRELİ, (Üsküdar Üniversitesi, Nöropsikofarmokoloji Uygulama ve Araştırma Merkezi, İstanbul, 34662, Türkiye)
Emel SERDAROĞLU KAŞIKÇI (Üsküdar Üniversitesi, Mühendislik ve Doğa Bilimleri Fakültesi, Moleküler Biyoloji ve Genetik Bölümü, İstanbul, 34662, Türkiye)
BOR DERGİSİ
8 2
Yıl: 2023 Cilt: 8 Sayı: 3 Sayfa Aralığı: 85 - 91 Metin Dili: Türkçe DOI: 10.30728/boron.1215949 İndeks Tarihi: 06-10-2023

Parkinson modelinde borik asit ve kuersetin kombinasyonunun oksidatif stres/bilişsel fonksiyon üzerine etkisi

Öz:
Parkinson hastalığı, beyinde dopaminerjik nöronlara etki eden önemli bir nörodejeneratif bozukluktur. Kuersetin, doğrudan radikal temizleme aktiviteleri ve antioksidatif enzimlerin indüksiyonu ile tüm flavonoidler arasında en güçlü antioksidanlardan biridir. Yapılan çalışmalarda Borik asidin kalsiyum, vitamin D ve magnezyum ile etkileşime girerek organlar için yararlı etkilere sahip olduğu gösterilmiştir. Bu çalışmada 3 aylık Wistar-albino erkek sıçandan oluşan deney grupları 8 gruba (n=7) ayrılmış ve beyin doku örneklerinde glutatyon ve malondialdehit seviyeleri manuel olarak belirlenmiştir. Aynı zamanda total antioksidan durumu (TAS), ticari kit kullanılarak tayin edilmiştir. Sıçanların bilişsel işlevlerini değerlendirmek için lokomotor aktivite ve nesne tanıma testleri uygulanmıştır. İstatistiksel analizlerde GraphPad Prism 9 versiyonu kullanılmıştır. Değerler, tek yönlü ANOVA ile istatistiksel olarak analiz edilmiş, gruplar arasındaki farklılıklar Uncorrected Fisher's LSD testleri kullanılarak belirlenmiştir. p<0,05 istatistiksel olarak anlamlı kabul edilmiştir. Buna göre bu çalışmanın sonucunda Kuersetin ve Borik asidin antioksidan kapasite üzerine olumlu etkiler yaparak TAS seviyelerinde etkili olduğu gösterilmiştir. Elde edilen veriler, borik asidin Parkinson hastalığı patogenezini önleyerek oksidan-antioksidan dengeyi olumlu yönde etkilediğini göstermiştir.
Anahtar Kelime: Borik asit Kuersetin Oksidatif stres Parkinson Rotenon

Effect of boric acid and quercetin combination on oxidative stress/cognitive function in parkinson model

Öz:
Parkinson's disease is an important neurodegenerative disorder that affects dopaminergic neurons in the brain. Quercetin is one of the most potent antioxidants among all flavonoids, with direct radical scavenging activities and induction of antioxidative enzymes. Studies have shown that boric acid interacts with calcium, vitamin D and magnesium to have beneficial effects for organs. In this study, experimental groups consisting of 3-month-old Wistar- albino male rats were divided into 8 groups (n=7) and glutathione and malondialdehyde levels were determined manually in brain tissue samples. Also, total antioxidant status (TAS) was determined using a commercial kit. Locomotor activity and object recognition tests were applied to evaluate the cognitive functions of the rats. GraphPad Prism 9 version was used for statistical analysis. Values were statistically analyzed with one-way ANOVA, and differences between groups were determined using Uncorrected Fisher's LSD tests. p<0.05 was considered statistically significant. Accordingly, as a result of this study, it has been shown that Quercetin and Boric acid have positive effects on antioxidant capacity and are effective in TAS levels. Obtained data has shown that boric acid would positively effect the oxidant-antioxidant balance by preventing the pathogenesis of Parkinson's disease.
Anahtar Kelime: Boric acid Quercetin Oxidative stress Parkinson Rotenone

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA Yavuz E, Çevik G, Cevreli B, Serdaroğlu Kaşıkçı E (2023). Parkinson modelinde borik asit ve kuersetin kombinasyonunun oksidatif stres/bilişsel fonksiyon üzerine etkisi. , 85 - 91. 10.30728/boron.1215949
Chicago Yavuz Elif,Çevik Güven,Cevreli Burcu,Serdaroğlu Kaşıkçı Emel Parkinson modelinde borik asit ve kuersetin kombinasyonunun oksidatif stres/bilişsel fonksiyon üzerine etkisi. (2023): 85 - 91. 10.30728/boron.1215949
MLA Yavuz Elif,Çevik Güven,Cevreli Burcu,Serdaroğlu Kaşıkçı Emel Parkinson modelinde borik asit ve kuersetin kombinasyonunun oksidatif stres/bilişsel fonksiyon üzerine etkisi. , 2023, ss.85 - 91. 10.30728/boron.1215949
AMA Yavuz E,Çevik G,Cevreli B,Serdaroğlu Kaşıkçı E Parkinson modelinde borik asit ve kuersetin kombinasyonunun oksidatif stres/bilişsel fonksiyon üzerine etkisi. . 2023; 85 - 91. 10.30728/boron.1215949
Vancouver Yavuz E,Çevik G,Cevreli B,Serdaroğlu Kaşıkçı E Parkinson modelinde borik asit ve kuersetin kombinasyonunun oksidatif stres/bilişsel fonksiyon üzerine etkisi. . 2023; 85 - 91. 10.30728/boron.1215949
IEEE Yavuz E,Çevik G,Cevreli B,Serdaroğlu Kaşıkçı E "Parkinson modelinde borik asit ve kuersetin kombinasyonunun oksidatif stres/bilişsel fonksiyon üzerine etkisi." , ss.85 - 91, 2023. 10.30728/boron.1215949
ISNAD Yavuz, Elif vd. "Parkinson modelinde borik asit ve kuersetin kombinasyonunun oksidatif stres/bilişsel fonksiyon üzerine etkisi". (2023), 85-91. https://doi.org/10.30728/boron.1215949
APA Yavuz E, Çevik G, Cevreli B, Serdaroğlu Kaşıkçı E (2023). Parkinson modelinde borik asit ve kuersetin kombinasyonunun oksidatif stres/bilişsel fonksiyon üzerine etkisi. BOR DERGİSİ, 8(3), 85 - 91. 10.30728/boron.1215949
Chicago Yavuz Elif,Çevik Güven,Cevreli Burcu,Serdaroğlu Kaşıkçı Emel Parkinson modelinde borik asit ve kuersetin kombinasyonunun oksidatif stres/bilişsel fonksiyon üzerine etkisi. BOR DERGİSİ 8, no.3 (2023): 85 - 91. 10.30728/boron.1215949
MLA Yavuz Elif,Çevik Güven,Cevreli Burcu,Serdaroğlu Kaşıkçı Emel Parkinson modelinde borik asit ve kuersetin kombinasyonunun oksidatif stres/bilişsel fonksiyon üzerine etkisi. BOR DERGİSİ, vol.8, no.3, 2023, ss.85 - 91. 10.30728/boron.1215949
AMA Yavuz E,Çevik G,Cevreli B,Serdaroğlu Kaşıkçı E Parkinson modelinde borik asit ve kuersetin kombinasyonunun oksidatif stres/bilişsel fonksiyon üzerine etkisi. BOR DERGİSİ. 2023; 8(3): 85 - 91. 10.30728/boron.1215949
Vancouver Yavuz E,Çevik G,Cevreli B,Serdaroğlu Kaşıkçı E Parkinson modelinde borik asit ve kuersetin kombinasyonunun oksidatif stres/bilişsel fonksiyon üzerine etkisi. BOR DERGİSİ. 2023; 8(3): 85 - 91. 10.30728/boron.1215949
IEEE Yavuz E,Çevik G,Cevreli B,Serdaroğlu Kaşıkçı E "Parkinson modelinde borik asit ve kuersetin kombinasyonunun oksidatif stres/bilişsel fonksiyon üzerine etkisi." BOR DERGİSİ, 8, ss.85 - 91, 2023. 10.30728/boron.1215949
ISNAD Yavuz, Elif vd. "Parkinson modelinde borik asit ve kuersetin kombinasyonunun oksidatif stres/bilişsel fonksiyon üzerine etkisi". BOR DERGİSİ 8/3 (2023), 85-91. https://doi.org/10.30728/boron.1215949
Sayfa Oluşturulma Tarihi
24-04-2024 13:32

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