TY  - JOUR
TI  - Antimicrobial, antifibrinolytic, enzyme inhibitory and wound healing properties of zinc borate
AB  - Boron containing compounds (BCGs) have recently been used for pharmaceutical applications. Zinc, an essential element, is known to be one of the most promising biodegradable metals. The present study was conducted to determine the wound healing properties of zinc borate with its antimicrobial, antifibrinolytic and enzyme inhibitory characteristics. In vitro scratch wound healing assay revealed that zinc borate at 0.01 µg/mL concentration stimulated the proliferation of 3T3 fibroblast cells after 24 h of scar formation. The highest enzyme inhibition was observed against collagenase at 1 mg/mL (81.5%). Minimum inhibition concentration (MIC) values were determined as 1 mg/mL and 0.5 mg/mL against Candida albicans and Staphylococcus aureus, respectively. Zinc borate did not have any fibrinolytic activity at 1, 0.5 and 0.1 mg/mL concentrations. It can be suggested that zinc borate can be used effectively to improve the wound healing process and to prevent the possible wound infections.
AU  - Ayrıkçil, Semih
AU  - Ugur, Aysel
AU  - Sarac, Nurdan
AU  - Boran, Rukiye
AU  - BAYGAR, TUBA
AU  - Yılmaz, Derviş
DO  - 10.30728/boron.1180847
PY  - 2023
JO  - BOR DERGİSİ
VL  - 8
IS  - 3
SN  - 2149-9020
SP  - 99
EP  - 104
DB  - TRDizin
UR  - http://search/yayin/detay/1199580
ER  -