Antidiabetic and Antioxidant Effect of Origanum minutiflorum O. Schwarz & P. H. Davis in Streptozotocin-Induced Diabetic Rats
Yıl: 2023 Cilt: 51 Sayı: 3 Sayfa Aralığı: 259 - 270 Metin Dili: İngilizce DOI: 10.15671/hjbc.1239345 İndeks Tarihi: 17-10-2023
Antidiabetic and Antioxidant Effect of Origanum minutiflorum O. Schwarz & P. H. Davis in Streptozotocin-Induced Diabetic Rats
Öz: In this study, the antidiabetic potential of aqueous extract of Origanum minutiflorum was tested using streptozotocin induced diabetic rats. Changes in body weight, blood glucose level, biochemical parameters, antioxidant enzyme activities and histopathological examination of kidney were evaluated. The administration of aqueous extract and carvacrol to diabetic group rats caused significant decrease in blood glucose, biochemical parameters of serum and significantly increased the concentration of high density lipoprotein cholesterol. The administration of aqueous extract and carvacrol significantly increased the antioxidant enzyme activity and reduced the MDA level. The histopathological analysis of kidney showed that aqueous extract and carvacrol had possible ameliorative effect against kidney damage. Aqueous extract is also showed α-amylase and α-glucosidase inhibitor activity with high antioxidant activity. These scientific results confirm the use of O. minutiflorum as adjuvant antidiabetic therapy.
Anahtar Kelime: Streptozotosin ile Indüklenmiş Diyabetik Sıçanlarda Origanum minutiflorum O. Schwarz & P. H. Davis’un Antidiyabetik ve Antioksidan Etkisi
Öz: Bu çalışmada, Origanum minutiflorum sulu ekstresinin streptozotosin ile indüklenmiş sıçanlarda antidiyabetik potansiyeli test edilmiştir. Vücut ağırlığındaki değişim, kan glikoz seviyesi, biyokimyasal parametreler, antioksidan enzim aktiviteleri ve böbreğin histopatolojik incelenmesi değerlendirilmiştir. Sulu ekstre ve karvakrolün diyabetik grup sıçanlarına uygulanma - sı kan glikoz seviyesi, serum biyokimyasal parametrelerde önemli derecede azalma ve yüksek yoğunluklu lipoprotein koles - terol seviyesinde önemli artışa sebep olmuştur. Sulu ekstre ve karvakrol uygulanması antioksidan enzim aktivitelerini önemli derecede artırırken, MDA seviyesini azaltmıştır. Böbreğin histopatolojik analizi, sulu ekstre ve karvakrolün böbrek hasarına karşı iyileştirici etkiye sahip olduğunu göstermektedir. Sulu ekstre aynı zamanda yüksek antioksidan aktivite ile α-amilaz ve α-glukosidaz inhibitor aktivite göstermiştir. Bu bilimsel sonuçlar O. minutiflorum’un antidiyabetik tedaviyi destekleyici olarak kullanımını doğrulamaktadır.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | Güllü İ, Albayrak S, KAYMAK E, Yay A (2023). Antidiabetic and Antioxidant Effect of Origanum minutiflorum O. Schwarz & P. H. Davis in Streptozotocin-Induced Diabetic Rats. , 259 - 270. 10.15671/hjbc.1239345 |
| Chicago | Güllü İsmail Bayram,Albayrak Sevil,KAYMAK EMIN,Yay Arzu Hanım Antidiabetic and Antioxidant Effect of Origanum minutiflorum O. Schwarz & P. H. Davis in Streptozotocin-Induced Diabetic Rats. (2023): 259 - 270. 10.15671/hjbc.1239345 |
| MLA | Güllü İsmail Bayram,Albayrak Sevil,KAYMAK EMIN,Yay Arzu Hanım Antidiabetic and Antioxidant Effect of Origanum minutiflorum O. Schwarz & P. H. Davis in Streptozotocin-Induced Diabetic Rats. , 2023, ss.259 - 270. 10.15671/hjbc.1239345 |
| AMA | Güllü İ,Albayrak S,KAYMAK E,Yay A Antidiabetic and Antioxidant Effect of Origanum minutiflorum O. Schwarz & P. H. Davis in Streptozotocin-Induced Diabetic Rats. . 2023; 259 - 270. 10.15671/hjbc.1239345 |
| Vancouver | Güllü İ,Albayrak S,KAYMAK E,Yay A Antidiabetic and Antioxidant Effect of Origanum minutiflorum O. Schwarz & P. H. Davis in Streptozotocin-Induced Diabetic Rats. . 2023; 259 - 270. 10.15671/hjbc.1239345 |
| IEEE | Güllü İ,Albayrak S,KAYMAK E,Yay A "Antidiabetic and Antioxidant Effect of Origanum minutiflorum O. Schwarz & P. H. Davis in Streptozotocin-Induced Diabetic Rats." , ss.259 - 270, 2023. 10.15671/hjbc.1239345 |
| ISNAD | Güllü, İsmail Bayram vd. "Antidiabetic and Antioxidant Effect of Origanum minutiflorum O. Schwarz & P. H. Davis in Streptozotocin-Induced Diabetic Rats". (2023), 259-270. https://doi.org/10.15671/hjbc.1239345 |
| APA | Güllü İ, Albayrak S, KAYMAK E, Yay A (2023). Antidiabetic and Antioxidant Effect of Origanum minutiflorum O. Schwarz & P. H. Davis in Streptozotocin-Induced Diabetic Rats. Hacettepe Journal of Biology and Chemistry, 51(3), 259 - 270. 10.15671/hjbc.1239345 |
| Chicago | Güllü İsmail Bayram,Albayrak Sevil,KAYMAK EMIN,Yay Arzu Hanım Antidiabetic and Antioxidant Effect of Origanum minutiflorum O. Schwarz & P. H. Davis in Streptozotocin-Induced Diabetic Rats. Hacettepe Journal of Biology and Chemistry 51, no.3 (2023): 259 - 270. 10.15671/hjbc.1239345 |
| MLA | Güllü İsmail Bayram,Albayrak Sevil,KAYMAK EMIN,Yay Arzu Hanım Antidiabetic and Antioxidant Effect of Origanum minutiflorum O. Schwarz & P. H. Davis in Streptozotocin-Induced Diabetic Rats. Hacettepe Journal of Biology and Chemistry, vol.51, no.3, 2023, ss.259 - 270. 10.15671/hjbc.1239345 |
| AMA | Güllü İ,Albayrak S,KAYMAK E,Yay A Antidiabetic and Antioxidant Effect of Origanum minutiflorum O. Schwarz & P. H. Davis in Streptozotocin-Induced Diabetic Rats. Hacettepe Journal of Biology and Chemistry. 2023; 51(3): 259 - 270. 10.15671/hjbc.1239345 |
| Vancouver | Güllü İ,Albayrak S,KAYMAK E,Yay A Antidiabetic and Antioxidant Effect of Origanum minutiflorum O. Schwarz & P. H. Davis in Streptozotocin-Induced Diabetic Rats. Hacettepe Journal of Biology and Chemistry. 2023; 51(3): 259 - 270. 10.15671/hjbc.1239345 |
| IEEE | Güllü İ,Albayrak S,KAYMAK E,Yay A "Antidiabetic and Antioxidant Effect of Origanum minutiflorum O. Schwarz & P. H. Davis in Streptozotocin-Induced Diabetic Rats." Hacettepe Journal of Biology and Chemistry, 51, ss.259 - 270, 2023. 10.15671/hjbc.1239345 |
| ISNAD | Güllü, İsmail Bayram vd. "Antidiabetic and Antioxidant Effect of Origanum minutiflorum O. Schwarz & P. H. Davis in Streptozotocin-Induced Diabetic Rats". Hacettepe Journal of Biology and Chemistry 51/3 (2023), 259-270. https://doi.org/10.15671/hjbc.1239345 |
