TY  - JOUR
TI  - Investigation on the Binding properties of a Coumarin Derivative to Insulin by Spectroscopic and Computational Approaches
AB  - The binding properties of insulin hormone to the potential antidiabetic coumarin derivative umbelliferone  (7hydroxycoumarin, 7HC) was investigated by absorption, fluorescence quenching and molecular docking methods. The negative signs of thermodynamic parameters (H and S) indicated that hydrogen bonds and van der Waals forces were dominant in the binding mode. The effect of common metal ions was investigated on binding parameters. According to the Förster’s theory; binding distance, r was obtained as 4.17 nm. The spectral data further supported by molecular docking calculations which show hydrogen bonds between 7HC and insulin.
AU  - Gökoğlu, Elmas
AU  - Aklar, Buse
AU  - TASKIN-TOK, Tugba
DO  - 10.15671/hjbc.1272350
PY  - 2023
JO  - Hacettepe Journal of Biology and Chemistry
VL  - 51
IS  - 3
SN  - 1303-5002
SP  - 297
EP  - 307
DB  - TRDizin
UR  - http://search/yayin/detay/1200449
ER  -