TY  - JOUR
TI  - Genetic factors and anterior cruciate ligament injury risk in professional football players: COL3A1 (rs1800255) and COL5A1 (rs12722) polymorphisms
AB  - This study was conducted to investigate the genotype and allele distributions of COL3A1 (rs1800255) and COL5A1 (rs12722) polymorphisms of professional footballers who have suffered at least 2 anterior cruciate ligament (ACL) injuries non-contact and professional footballers who have never had a ligament injury. The research group consists of 108 professional men's football players ACL group (n=45), Control group (n=63) with at least 10 years of football background. The results ACL and control groups were compared by Chi-square or Fischer’s exact test.  There were no significant differences noted neither in terms of genotype distribution of COL3A1 (rs1800255) nor A-allele frequency distribution between control (CON) and ACL group. A highly significant difference in the allele distribution was noted for COL5A1 (rs12722) with the T-allele significantly less frequent in CON than ACL. The TT genotype compared to the C alleles (TC + CC) showed significant relationship between the TT genotype and ACL injury potential in the dominant model. However, it was not showing significance in the recessive (TT + TC vs. CC). In conclusion, it can be said that professional football players who have the COL5A1 rs12722 C allele have about 2 times lower risk of anterior cruciate ligament injury. In the COL3A1 rs1800255 polymorphism, there is no relationship between the groups in terms of genotypes and allele distribution.
AU  - bülbül, alpay
AU  - Şavkın, Sadegul
AU  - APAYDIN, NECDET
AU  - ipekoğlu, Gökhan
AU  - Çakır, Halil İbrahim
AU  - Bozkurt, Nihan
DO  - 10.31459/turkjkin.1329105
PY  - 2023
JO  - Turkish Journal of Kinesiology
VL  - 9
IS  - 3
SN  - 2459-0134
SP  - 195
EP  - 203
DB  - TRDizin
UR  - http://search/yayin/detay/1200647
ER  -