Effect of Barley Grass Juice on Antioxidant Capacity and DNA Damage in Diabetic Rats

BAŞBUĞAN, Yıldıray; COMBA, BAHAT; SARIPINAR AKSU, Devrim; Comba, Arzu; mis, leyla

doi:10.52827/hititmedj.1281145

Effect of Barley Grass Juice on Antioxidant Capacity and DNA Damage in Diabetic Rats

Arzu COMBA, (Hitit Üniversitesi, Teknik Bilimler Meslek Yüksekokulu, Çorum, Türkiye)

Leyla MİS, (Yüzüncü Yıl Üniversitesi, Veteriner Fakültesi, Van, Türkiye)

Devrim SARIPINAR AKSU, (Yüzüncü Yıl Üniversitesi, Veteriner Fakültesi, Van, Türkiye)

Yıldıray BASBUGAN, (Yüzüncü Yıl Üniversitesi, Veteriner Fakültesi, Van, Türkiye)

Bahat COMBA (Hitit Üniversitesi, Teknik Bilimler Meslek Yüksekokulu, Çorum, Türkiye)

Hitit medical journal (Online)

3 0

Yıl: 2023 Cilt: 5 Sayı: 3 Sayfa Aralığı: 149 - 155 Metin Dili: İngilizce DOI: 10.52827/hititmedj.1281145 İndeks Tarihi: 16-10-2023

Effect of Barley Grass Juice on Antioxidant Capacity and DNA Damage in Diabetic Rats

Öz:

Objective: Worldwide, phytotherapy methods acquire great importance, and studies in this field are increasing their importance each day. This study, it was aimed to examine total antioxidant, oxidant status, oxidative DNA damage, glucose and hemoglobin A1c levels and the effects of barley grass juice on these parameters in rats with diabetes mellitus. Material and Method: Four groups were formed for the study and 6 male rats weighing 250-350 g were used in each group. Control Group; physiological saline was injected via intraperitoneal., Diabetic Group; created using streptozotocin, Barley Grass Group; Barley grass juice (3 ml/rat/day) was given orally for 4 weeks, Diabetic and Barley Grass Group; was injected streptozotocin and barley grass juice was given by oral for 4 weeks. Results: It was determined that barley grass juice decreased blood sugar, glucose, hemoglobin A1c, total oxidative status and oxidative stress index values, increased total anti-oxidative status value, and body weights in streptozotocin-induced diabetes. In addition, it was determined that the addition of barley grass juice provided a significant protective effect and improvement in these parameters. Conclusion: Based on these findings, we can say that barley grass juice has an antidiabetic-antioxidant effect and weight gain in diabetes mellitus

Anahtar Kelime: Antioxidant Barley grass juice Diabetes mellitus DNA damage Glucose HbA1c Oxidan

Arpa Çiminin Diyabetli Ratlarda Antioksidan Kapasitesine ve DNA Hasarına Etkisi

Öz:

Amaç: Dünya çapında fitoterapi yöntemleri büyük önem kazanmakta ve bu alandaki çalışmalar her geçen gün önemini artırmaktadır. Bu çalışmada deneysel olarak diyabet oluşturulan ratlarda toplam antioksidan, oksidan durum, oksidatif DNA hasarı, glikoz ve hemoglobin A1c düzeyleri ve arpa çimi suyunun bu parametreler üzerine etkisinin incelenmesi amaçlandı. Gereç ve yöntem: Çalışma için 4 grup oluşturuldu ve her grupta 250-350 gr ağırlığında 6 erkek rat kullanıldı. Kontrol grubu; serum fizyolojik periton içi yol ile enjekte edildi, Diyabet grubu; diyabet, streptozotosin kullanılarak oluşturuldu, Arpa çimi grubu; 4 hafta oral olarak arpa çimi suyu (3 ml/sıçan/gün) verildi, Diyabet+Arpa çimi grubu; streptozotosin ile diyabet oluşturuldu ve 4 hafta boyunca arpa çimi suyu oral olarak verildi. Bulgular: Arpa çimi suyu, streptozotosin kaynaklı diyabette kan şekeri, glikoz, HemoglobinA1c, toplam oksidatif durum ve oksidatif stres gösterge değerlerini düşürdüğü, toplam antioksidan değerini ve canlı ağırlıkları arttırdığı belirlendi. Ayrıca arpa çimi suyu ilavesinin bu parametreler üzerinde belirgin koruyucu etki ve iyileşme sağladığı tespit edildi. Sonuç: Bu bulgulardan yola çıkarak arpa çimi suyunun şeker hastalığında anti-diyabetik, anti-oksidan etki gösterdiği ve kilo kaybını önlediğini söyleyebiliriz.

Anahtar Kelime: Antioksidan Arpa çimi suyu Diyabet DNA hasarı Glikoz HbA1c Oksidan

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Comba A, mis l, SARIPINAR AKSU D, BAŞBUĞAN Y, COMBA B (2023). Effect of Barley Grass Juice on Antioxidant Capacity and DNA Damage in Diabetic Rats. , 149 - 155. 10.52827/hititmedj.1281145
Chicago	Comba Arzu,mis leyla,SARIPINAR AKSU Devrim,BAŞBUĞAN Yıldıray,COMBA BAHAT Effect of Barley Grass Juice on Antioxidant Capacity and DNA Damage in Diabetic Rats. (2023): 149 - 155. 10.52827/hititmedj.1281145
MLA	Comba Arzu,mis leyla,SARIPINAR AKSU Devrim,BAŞBUĞAN Yıldıray,COMBA BAHAT Effect of Barley Grass Juice on Antioxidant Capacity and DNA Damage in Diabetic Rats. , 2023, ss.149 - 155. 10.52827/hititmedj.1281145
AMA	Comba A,mis l,SARIPINAR AKSU D,BAŞBUĞAN Y,COMBA B Effect of Barley Grass Juice on Antioxidant Capacity and DNA Damage in Diabetic Rats. . 2023; 149 - 155. 10.52827/hititmedj.1281145
Vancouver	Comba A,mis l,SARIPINAR AKSU D,BAŞBUĞAN Y,COMBA B Effect of Barley Grass Juice on Antioxidant Capacity and DNA Damage in Diabetic Rats. . 2023; 149 - 155. 10.52827/hititmedj.1281145
IEEE	Comba A,mis l,SARIPINAR AKSU D,BAŞBUĞAN Y,COMBA B "Effect of Barley Grass Juice on Antioxidant Capacity and DNA Damage in Diabetic Rats." , ss.149 - 155, 2023. 10.52827/hititmedj.1281145
ISNAD	Comba, Arzu vd. "Effect of Barley Grass Juice on Antioxidant Capacity and DNA Damage in Diabetic Rats". (2023), 149-155. https://doi.org/10.52827/hititmedj.1281145

APA	Comba A, mis l, SARIPINAR AKSU D, BAŞBUĞAN Y, COMBA B (2023). Effect of Barley Grass Juice on Antioxidant Capacity and DNA Damage in Diabetic Rats. Hitit medical journal (Online), 5(3), 149 - 155. 10.52827/hititmedj.1281145
Chicago	Comba Arzu,mis leyla,SARIPINAR AKSU Devrim,BAŞBUĞAN Yıldıray,COMBA BAHAT Effect of Barley Grass Juice on Antioxidant Capacity and DNA Damage in Diabetic Rats. Hitit medical journal (Online) 5, no.3 (2023): 149 - 155. 10.52827/hititmedj.1281145
MLA	Comba Arzu,mis leyla,SARIPINAR AKSU Devrim,BAŞBUĞAN Yıldıray,COMBA BAHAT Effect of Barley Grass Juice on Antioxidant Capacity and DNA Damage in Diabetic Rats. Hitit medical journal (Online), vol.5, no.3, 2023, ss.149 - 155. 10.52827/hititmedj.1281145
AMA	Comba A,mis l,SARIPINAR AKSU D,BAŞBUĞAN Y,COMBA B Effect of Barley Grass Juice on Antioxidant Capacity and DNA Damage in Diabetic Rats. Hitit medical journal (Online). 2023; 5(3): 149 - 155. 10.52827/hititmedj.1281145
Vancouver	Comba A,mis l,SARIPINAR AKSU D,BAŞBUĞAN Y,COMBA B Effect of Barley Grass Juice on Antioxidant Capacity and DNA Damage in Diabetic Rats. Hitit medical journal (Online). 2023; 5(3): 149 - 155. 10.52827/hititmedj.1281145
IEEE	Comba A,mis l,SARIPINAR AKSU D,BAŞBUĞAN Y,COMBA B "Effect of Barley Grass Juice on Antioxidant Capacity and DNA Damage in Diabetic Rats." Hitit medical journal (Online), 5, ss.149 - 155, 2023. 10.52827/hititmedj.1281145
ISNAD	Comba, Arzu vd. "Effect of Barley Grass Juice on Antioxidant Capacity and DNA Damage in Diabetic Rats". Hitit medical journal (Online) 5/3 (2023), 149-155. https://doi.org/10.52827/hititmedj.1281145