ABSTRACT Objective: Nursing care is important at every stage of the treatment of ovarian cancer, which has a high mortality rate among gynecological cancers. In this case, it is aimed to describe the post-operative problems of the patient who underwent surgery with the diagnosis of ovarian cancer within the scope of Orem's Self-Care Deficiency Theory and to explain the theory-based nursing care management. Case: The 57-year-old patient E.H. the suspicion of free fluid in the abdomen was directed to the institution upon interview. The patient who was diagnosed with ovarian cancer underwent surgery and was discharged from the hospital on the 8th post op day. During the post-operative care period, “bleeding, infection, impaired respiratory function, acute pain, nausea, constipation, activity intolerance, lack of self-care, fluid volume imbalance, lack of knowledge, risk of thromboembolism and risk of falls” nursing diagnoses were made. Conclusion: As a result of the applied nursing care, it was seen that the self-care power of the patient was positively affected. The applications that the patient can do independently have increased. It is considered that this study can set an example in the care applications of nurses working in the area of gynecological oncology.