Effects of pancreatic denervation on secretion of pancreatic hormones in rats

Tanbek, Kevser; Sandal, Suleyman

doi:10.5455/annalsmedres.2023.05.115

Effects of pancreatic denervation on secretion of pancreatic hormones in rats

Kevser TANBEK, (İnönü Üniversitesi, Tıp Fakültesi, Fizyoloji Anabilim Dalı, Malatya, Türkiye)

Suleyman SANDAL (İnönü Üniversitesi, Tıp Fakültesi, Fizyoloji Anabilim Dalı, Malatya, Türkiye)

Annals of Medical Research

4 0

Yıl: 2023 Cilt: 30 Sayı: 10 Sayfa Aralığı: 1353 - 1358 Metin Dili: İngilizce DOI: 10.5455/annalsmedres.2023.05.115 İndeks Tarihi: 31-10-2023

Effects of pancreatic denervation on secretion of pancreatic hormones in rats

Öz:

Aim: The aim of this study was to determine whether expermentaly pancreatic denervation (PD) injury caused effects on pancreatic tissue and endocrine secretions. Materials and Methods: A total of 50 adult male Wistar Albino rats (8 weeks old, 280-300 g) were randomly divided into five groups (n=10) as Control, Sham acute, PD acute, Sham chronic, PD chronic. The PD procedure was performed by cutting the pancreatic vagal and splenic nerves. Sham acute and PD acute groups were sacrificed 120 minutes after the PD procedure, while Control, Sham chronic, and PD chronic groups were sacrificed 7 days after the PD procedure. Pancreatic tissues were collected after the rats were sacrificed. Tissue samples were homogenized, and insulin, glucagon and norepinephrine levels were measured using commercial ELISA kits. Statistical analysis of the data was conducted using the Bonferroni-corrected Mann-Whitney U test in the IBM SPSS Statistics 24.0 Windows program. Results: The decrease in norepinephrine level of pancreas tissue was found to be significant PD groups compared to Control and Sham groups. The decrease of glucagon and insulin level was found to be significant in PD acute and PD cronic compared to Contol and Sham groups. Conclusion: According to our findings, pancreatic denervation short and long term effects were effective in insulin and glucagon secretion in the model which examined in pancreatic denervation groups.

Anahtar Kelime: Brain Pancreatic denervation Pancreas Insulin Glucagon Norepinephrine

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Tanbek K, Sandal S (2023). Effects of pancreatic denervation on secretion of pancreatic hormones in rats. , 1353 - 1358. 10.5455/annalsmedres.2023.05.115
Chicago	Tanbek Kevser,Sandal Suleyman Effects of pancreatic denervation on secretion of pancreatic hormones in rats. (2023): 1353 - 1358. 10.5455/annalsmedres.2023.05.115
MLA	Tanbek Kevser,Sandal Suleyman Effects of pancreatic denervation on secretion of pancreatic hormones in rats. , 2023, ss.1353 - 1358. 10.5455/annalsmedres.2023.05.115
AMA	Tanbek K,Sandal S Effects of pancreatic denervation on secretion of pancreatic hormones in rats. . 2023; 1353 - 1358. 10.5455/annalsmedres.2023.05.115
Vancouver	Tanbek K,Sandal S Effects of pancreatic denervation on secretion of pancreatic hormones in rats. . 2023; 1353 - 1358. 10.5455/annalsmedres.2023.05.115
IEEE	Tanbek K,Sandal S "Effects of pancreatic denervation on secretion of pancreatic hormones in rats." , ss.1353 - 1358, 2023. 10.5455/annalsmedres.2023.05.115
ISNAD	Tanbek, Kevser - Sandal, Suleyman. "Effects of pancreatic denervation on secretion of pancreatic hormones in rats". (2023), 1353-1358. https://doi.org/10.5455/annalsmedres.2023.05.115

APA	Tanbek K, Sandal S (2023). Effects of pancreatic denervation on secretion of pancreatic hormones in rats. Annals of Medical Research, 30(10), 1353 - 1358. 10.5455/annalsmedres.2023.05.115
Chicago	Tanbek Kevser,Sandal Suleyman Effects of pancreatic denervation on secretion of pancreatic hormones in rats. Annals of Medical Research 30, no.10 (2023): 1353 - 1358. 10.5455/annalsmedres.2023.05.115
MLA	Tanbek Kevser,Sandal Suleyman Effects of pancreatic denervation on secretion of pancreatic hormones in rats. Annals of Medical Research, vol.30, no.10, 2023, ss.1353 - 1358. 10.5455/annalsmedres.2023.05.115
AMA	Tanbek K,Sandal S Effects of pancreatic denervation on secretion of pancreatic hormones in rats. Annals of Medical Research. 2023; 30(10): 1353 - 1358. 10.5455/annalsmedres.2023.05.115
Vancouver	Tanbek K,Sandal S Effects of pancreatic denervation on secretion of pancreatic hormones in rats. Annals of Medical Research. 2023; 30(10): 1353 - 1358. 10.5455/annalsmedres.2023.05.115
IEEE	Tanbek K,Sandal S "Effects of pancreatic denervation on secretion of pancreatic hormones in rats." Annals of Medical Research, 30, ss.1353 - 1358, 2023. 10.5455/annalsmedres.2023.05.115
ISNAD	Tanbek, Kevser - Sandal, Suleyman. "Effects of pancreatic denervation on secretion of pancreatic hormones in rats". Annals of Medical Research 30/10 (2023), 1353-1358. https://doi.org/10.5455/annalsmedres.2023.05.115