TY  - JOUR
TI  - Effects of Bromelain on Oxidative Stress and Lung Tissue Histopathology in an Experimental Rat Sepsis Model
AB  - Sepsis is an inflammatory syndrome that targets the lung tissue. Bromelain (BRO) is an enzyme complex known for its anti-inflammatory properties. In this study, the protective effect of BRO on lung injury due to sepsis induced by cecal ligation and puncture (CLP) in Sprague-Dawley rats was investigated by biochemical and histopathological methods. Forty Sprague dawley rats were randomly divided into five groups as control, CLP, BRO, CLP+BRO 50 and CLP+BRO 100. In the study, after oral administration of 50 and 100 mg/kg BRO (total of 7 applications for 7 days) to rats, laparotomy and CLP were performed. The data showed that due to its antioxidant properties, BRO decreased CLP-induced myeloperoxidase (MPO) and lipid peroxidation (MDA) (p
AU  - akaras, nurhan
AU  - Simsek, Hasan
AU  - AYDEMİR CELEP, NEVRA
AU  - Yüce, Neslihan
AU  - TOKTAY, Erdem
DO  - 10.30607/kvj.1302701
PY  - 2023
JO  - Kocatepe Veterinary Journal
VL  - 16
IS  - 3
SN  - 1308-1594
SP  - 252
EP  - 259
DB  - TRDizin
UR  - http://search/yayin/detay/1204590
ER  -