TY  - JOUR
TI  - Investigation of the Effects of Rutin on Valproic Acid Induced Testicular Damage in Rats
AB  - Valproic acid (VALP) is a drug used for many psychiatric diseases such as epilepsy. However, the use of VALP has potential side effects on various tissues, including the testicles. Rutin (RUT) is a flavonoid with protective effects against oxidative stress-induced diseases and lipid peroxidation. In this study, the protective effects of RUT against testicular damage caused by VALP were investigated. For this purpose, 35 male Spraque-Dawley rats weighing 220-250 g were used in the study. The rats were randomly divided into 5 groups as Control (physiological saline), RUT (100 mg/kg/bw), VALP, (500mg/kg/bw), VALP+RUT 50 (500 mg/kg/bw VALP+50 mg/kg/bw RUT), and VALP +RUT 100 (500 mg/kg/bw VALP+100 mg/kg/bw RUT). At the end of the RUT and VALP administrations, the rats were sacrificed and testicular tissues were taken to be used for biochemical and spermatological analyzes. According to the results of this study, the MDA level in the testicular tissues of the VALP group was found to be statistically higher than the other experimental groups (p
AU  - akarsu, serkan ali
AU  - KANKILIC, NAZIM A
AU  - ERDOĞAN, ENDER
DO  - 10.30607/kvj.1295945
PY  - 2023
JO  - Kocatepe Veterinary Journal
VL  - 16
IS  - 3
SN  - 1308-1594
SP  - 260
EP  - 268
DB  - TRDizin
UR  - http://search/yayin/detay/1204591
ER  -