Migraine chronification is associated with higher body mass index and elevated serum interleukin-6 levels

Vurallı, Doğa; Bolay, Hayrunnisa

doi:10.5455/annalsmedres.2023.08.226

Migraine chronification is associated with higher body mass index and elevated serum interleukin-6 levels

Doga VURALLİ, (Gazi Üniversitesi, Tıp Fakültesi, Nöroloji ve Algoloji Anabilim Dalı, Nöropsikiyatri Merkezi Sinirbilim ve Nöroteknoloji Mükemmeliyet Merkezi (NÖROM), Ankara, Türkiye)

Hayrunnisa BOLAY (Gazi Üniversitesi, Tıp Fakültesi, Nöroloji ve Algoloji Anabilim Dalı, Nöropsikiyatri Merkezi Sinirbilim ve Nöroteknoloji Mükemmeliyet Merkezi (NÖROM), Ankara, Türkiye)

Annals of Medical Research

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Yıl: 2023 Cilt: 30 Sayı: 9 Sayfa Aralığı: 1149 - 1152 Metin Dili: İngilizce DOI: 10.5455/annalsmedres.2023.08.226 İndeks Tarihi: 01-11-2023

Migraine chronification is associated with higher body mass index and elevated serum interleukin-6 levels

Öz:

Aim: Chronification of migraine is a serious health problem with difficulties in management and is related to increased disability. Inflammation is suggested to have a role in migraine and its chronification. We aimed to determine whether systemic inflammatory response tested by serum interleukin-6 (IL-6) levels and obesity were related to migraine attack frequency. Materials and Methods: A total of 40 female participants (20 chronic migraine patients, 10 episodic migraine patients, 10 healthy controls without headache) were included in the study. None of the migraine patients were on migraine prophylaxis. Episodic migraine patients were evaluated interictally with a 72 hour headache free period before and after blood collection. Migraine headache frequency, body mass index (BMI) and age of the patients were recorded. Serum IL-6 levels were measured by ELISA method. Results: Serum IL-6 levels were significantly elevated in chronic migraine patients compared to episodic migraine patients and healthy controls. Chronic migraine patients were overweight with a BMI greater than 25 kg/m2 . BMI was higher in chronic migraine patients compared to episodic migraine patients and healthy subjects even though it did not reach statistical significance. Serum IL-6 levels and BMI were positively correlated with migraine headache frequency. Conclusion: Elevated systemic circulating IL-6 levels and BMI were related to an increase in migraine headache frequency. BMI and serum IL-6 levels seem to be risk factors for chronic migraine in women. Strategies to reduce inflammation and obesity must be integrated to the treatment of chronic migraine. Identification of modifiable risk factors for chronification of migraine is crucial for sustainable treatment of migraine.

Anahtar Kelime: Chronic migraine Interleukin-6 Body mass index Inflammation

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Vurallı D, Bolay H (2023). Migraine chronification is associated with higher body mass index and elevated serum interleukin-6 levels. , 1149 - 1152. 10.5455/annalsmedres.2023.08.226
Chicago	Vurallı Doğa,Bolay Hayrunnisa Migraine chronification is associated with higher body mass index and elevated serum interleukin-6 levels. (2023): 1149 - 1152. 10.5455/annalsmedres.2023.08.226
MLA	Vurallı Doğa,Bolay Hayrunnisa Migraine chronification is associated with higher body mass index and elevated serum interleukin-6 levels. , 2023, ss.1149 - 1152. 10.5455/annalsmedres.2023.08.226
AMA	Vurallı D,Bolay H Migraine chronification is associated with higher body mass index and elevated serum interleukin-6 levels. . 2023; 1149 - 1152. 10.5455/annalsmedres.2023.08.226
Vancouver	Vurallı D,Bolay H Migraine chronification is associated with higher body mass index and elevated serum interleukin-6 levels. . 2023; 1149 - 1152. 10.5455/annalsmedres.2023.08.226
IEEE	Vurallı D,Bolay H "Migraine chronification is associated with higher body mass index and elevated serum interleukin-6 levels." , ss.1149 - 1152, 2023. 10.5455/annalsmedres.2023.08.226
ISNAD	Vurallı, Doğa - Bolay, Hayrunnisa. "Migraine chronification is associated with higher body mass index and elevated serum interleukin-6 levels". (2023), 1149-1152. https://doi.org/10.5455/annalsmedres.2023.08.226

APA	Vurallı D, Bolay H (2023). Migraine chronification is associated with higher body mass index and elevated serum interleukin-6 levels. Annals of Medical Research, 30(9), 1149 - 1152. 10.5455/annalsmedres.2023.08.226
Chicago	Vurallı Doğa,Bolay Hayrunnisa Migraine chronification is associated with higher body mass index and elevated serum interleukin-6 levels. Annals of Medical Research 30, no.9 (2023): 1149 - 1152. 10.5455/annalsmedres.2023.08.226
MLA	Vurallı Doğa,Bolay Hayrunnisa Migraine chronification is associated with higher body mass index and elevated serum interleukin-6 levels. Annals of Medical Research, vol.30, no.9, 2023, ss.1149 - 1152. 10.5455/annalsmedres.2023.08.226
AMA	Vurallı D,Bolay H Migraine chronification is associated with higher body mass index and elevated serum interleukin-6 levels. Annals of Medical Research. 2023; 30(9): 1149 - 1152. 10.5455/annalsmedres.2023.08.226
Vancouver	Vurallı D,Bolay H Migraine chronification is associated with higher body mass index and elevated serum interleukin-6 levels. Annals of Medical Research. 2023; 30(9): 1149 - 1152. 10.5455/annalsmedres.2023.08.226
IEEE	Vurallı D,Bolay H "Migraine chronification is associated with higher body mass index and elevated serum interleukin-6 levels." Annals of Medical Research, 30, ss.1149 - 1152, 2023. 10.5455/annalsmedres.2023.08.226
ISNAD	Vurallı, Doğa - Bolay, Hayrunnisa. "Migraine chronification is associated with higher body mass index and elevated serum interleukin-6 levels". Annals of Medical Research 30/9 (2023), 1149-1152. https://doi.org/10.5455/annalsmedres.2023.08.226