Relationship between Hematological Inflammatory Markers and General Characteristics in Operable Cervical Cancer; State of the HALP index

Bilir, Filiz; Batman, Didem; ÇORAKÇI, AYDIN; yucesoy, izzet

doi:10.31832/smj.1319887

Relationship between Hematological Inflammatory Markers and General Characteristics in Operable Cervical Cancer; State of the HALP index

Filiz BİLİR, (Kocaeli Üniversitesi, Tıp Fakültesi, Kadın Hastalıkları ve Doğum Anabilim Dalı, Kocaeli, Türkiye)

Didem BATMAN, (Kocaeli Üniversitesi, Tıp Fakültesi, Kadın Hastalıkları ve Doğum Anabilim Dalı, Kocaeli, Türkiye)

Aydın ÇORAKÇI, (Kocaeli Üniversitesi, Tıp Fakültesi, Kadın Hastalıkları ve Doğum Anabilim Dalı, Kocaeli, Türkiye)

İzzet YÜCESOY (Kocaeli Üniversitesi, Tıp Fakültesi, Kadın Hastalıkları ve Doğum Anabilim Dalı, Kocaeli, Türkiye)

Sakarya Tıp Dergisi

2 0

Yıl: 2023 Cilt: 13 Sayı: 3 Sayfa Aralığı: 384 - 389 Metin Dili: İngilizce DOI: 10.31832/smj.1319887 İndeks Tarihi: 03-11-2023

Relationship between Hematological Inflammatory Markers and General Characteristics in Operable Cervical Cancer; State of the HALP index

Öz:

Background: Cervical cancer is the most common gynecologic malignancy and the leading cause of cancer-related mortality in women worldwide. Systemic inflammatory reactions in cancer patients impact nutrition, function, and prognosis. Poor nutritional health is linked to a worse prognosis in several malignancies. A new score called the hemoglobin-albumin-lymphocyte-platelet (HALP) index was developed using dietary and inflammatory deficiencies. Method: This retrospective study and CC patients diagnosed from January 2012 to December 2020 who were operated for cervical cancer. Pre-treatment hemoglobin (Hb), albumin (Alb), lymphocyte count (Lc), and platelet (Plt) measurements were made for laboratory research. Results: This retrospective study revealed 74 non-metastatic cervical cancer (median age was 55, ranging from 30 to 86 years). According to the FIGO stage, the percentage of stages 1 and 2 were 78% (58 patients), and 22% (16 patients). Neutrophil lymphocyte ratio (NLR) and platelet lymphocyte ratio (PLR), and HALP index were analyzed with LVSI, parametrial invasion, tumor size, histologic type, and duration of hospital stay; we could not find any significant correlation between the analysis. Conclusion: NLR, PLR, and HALP index have no prognostic value in early operable cervical cancer patients regarding the pathologic features. Prospective multicenter and more patient studies will clarify how the hematologic parameters affect oncologic outcomes.

Anahtar Kelime: HALP İNndex Cervİcal Cancer Hematologİc parameters Prognostİc value

Ameliyat edilebilir Rahim Ağzı Kanserinde Hematolojik İnflamatuar Belirteçler ile Genel Özellikler Arasındaki İlişki; HALP indeksinin yeri

Öz:

Giriş: Rahim ağzı kanseri en yaygın jinekolojik malignitedir ve dünya çapında kadınlarda kansere bağlı ölümlerin önde gelen nedenidir. Kanser hastalarında sistemik inflamatuar reaksiyonlar beslenmeyi, fonksiyonları ve prognozu etkiler. Kötü beslenme sağlığı, birçok kanserde kötü prognozla bağlantılıdır. Hemoglobin-albümin-lenfosit-trombosit (HALP) indeksi adı verilen yeni bir skor, diyet ve enflamatuar belirteçleri kullanılarak geliştirilen bir indekstir. Yöntem: Bu retrospektif çalışma Ocak 2012-Aralık 2020 tarihleri arasında serviks kanseri nedeniyle opere edilen SK hastalarını retrospektif incelemiştir. Laboratuvar araştırması için tedavi öncesi hemoglobin (Hb), albümin (Alb), lenfosit sayısı (Lc) ve trombosit (Plt) ölçümleri yapıldı. Bulgular: Bu retrospektif çalışma, 74 metastatik olmayan serviks kanserinden oluşmaktaydı (medyan yaş 55, 30 ila 86 arasındaydı). FIGO evresine göre evre 1 ve 2'nin yüzdesi %78 (58 hasta), %22 (16 hasta) idi. Nötrofil lenfosit oranı (NLR) ve trombosit lenfosit oranı (PLR) ve HALP indeksi, LVSI, parametriyal invazyon, tümör boyutu, histolojik tip ve hastanede kalış süresi ile analiz edildi; sonuç olarak analizler arasında anlamlı bir ilişki bulamadık. Sonuç: NLR, PLR ve HALP indeksinin erken opere edilebilir serviks kanseri hastalarında patolojik özellikler açısından prognostik değeri yoktu. Prospektif çok merkezli ve daha fazla hasta sayısından oluşan çalışmalar, hematolojik parametrelerin onkolojik sonuçları nasıl etkilediğini netleştirecektir.

Anahtar Kelime: HALP indeksi serviks kanseri hematolojik belirteçler prognostik değer

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

1. Urbán N, Guillemot F. Neurogenesis in the embryonic and adult brain: same regulators, diff erent roles. Front Cell Neurosci. 2014;8(NOV). doi:10.3389/FNCEL.2014.00396
2. Eriksson PS, Perfilieva E, Björk-Eriksson T, et al. Neurogenesis in the adult human hippo- campus. Nat Med 1998 411. 1998;4(11):1313-1317. doi:10.1038/3305
3. Moreno-Jiménez EP, Flor-García M, Terreros-Roncal J, et al. Adult hippocampal neuroge- nesis is abundant in neurologically healthy subjects and drops sharply in patients with Alz- heimer’s disease. Nat Med 2019 254. 2019;25(4):554-560. doi:10.1038/s41591-019-0375-9
4. Lipp HP, Bonfanti L. Adult Neurogenesis in Mammals: Variations and Confusions. Brain Behav Evol. 2016;87(3):205-221. doi:10.1159/000446905
5. Kempermann G. Environmental enrichment, new neurons and the neurobiology of indivi- duality. Nat Rev Neurosci 2019 204. 2019;20(4):235-245. doi:10.1038/s41583-019-0120-x
6. Lim DA, Alvarez-Buylla A. Th e Adult Ventricular–Subventricular Zone (V-SVZ) and Olfactory Bulb (OB) Neurogenesis. Cold Spring Harb Perspect Biol. 2016;8(5):a018820. doi:10.1101/CSHPERSPECT.A018820
7. Aimone JB, Li Y, Lee SW, Clemenson GD, Deng W, Gage FH. Regulation and function of adult neurogenesis: from genes to cognition. Physiol Rev. 2014;94(4):991-1026. doi:10.1152/ PHYSREV.00004.2014/ASSET/IMAGES/LARGE/Z9J0041427010007.JPEG
8. Welberg L. Adult neurogenesis is altered in neurodegenerative disease. Nat Neurosci 2021 2412. 2021;24(12):1640-1640. doi:10.1038/s41593-021-00978-3
9. Gordon J, Amini S. General Overview of Neuronal Cell Culture. Methods Mol Biol. 2021;2311:1-8. doi:10.1007/978-1-0716-1437-2_1/COVER
10. Darbinian N. Cultured Cell Line Models of Neuronal Diff erentiation: NT2, PC12, and SK- N-MC. Methods Mol Biol. 2021;2311:25-38. doi:10.1007/978-1-0716-1437-2_3/COVER
11. Wang C, Cai X, Hu W, et al. Investigation of the neuroprotective eff ects of crocin via an- tioxidant activities in HT22 cells and in mice with Alzheimer’s disease. Int J Mol Med. 2019;43(2):956-966. doi:10.3892/IJMM.2018.4032/HTML
12. Park JS, Park JH, Kim KY. Neuroprotective eff ects of myristargenol A against glutama- te-induced apoptotic HT22 cell death. RSC Adv. 2019;9(54):31247-31254. doi:10.1039/ C9RA05408A
13. Davis JB, Maher P. Protein kinase C activation inhibits glutamate-induced cytotoxicity in a neuronal cell line. Brain Res. 1994;652(1):169-173. doi:10.1016/0006-8993(94)90334-4
14. Ishikawa M, Aoyama T, Shibata S, et al. miRNA-Based Rapid Diff erentiation of Purified Neurons from hPSCs Advancestowards Quick Screening for Neuronal Disease Phenotypes In Vitro. Cells. 2020;9(3). doi:10.3390/CELLS9030532
15. Bratton DL, Fadok VA, Richter DA, Kailey JM, Guthrie LA, Henson PM. Appearan- ce of Phosphatidylserine on Apoptotic Cells Requires Calcium-mediated Nonspecific Flip-Flop and Is Enhanced by Loss of the Aminophospholipid Translocase. J Biol Chem. 1997;272(42):26159-26165. doi:10.1074/JBC.272.42.26159
16. Zhang G, Gurtu V, Kain SR, Yan G. Early Detection of Apoptosis Using a Fluorescent Conjugate of Annexin V. https://doi.org/102144/97233pf01. 2018;23(3):525-531. do- i:10.2144/97233PF01
17. Elmore S. Apoptosis: A Review of Programmed Cell Death. Toxicol Pathol. 2007;35(4):495. doi:10.1080/01926230701320337
18. Brauchle E, Th ude S, Brucker SY, Schenke-Layland K. Cell death stages in single apoptotic and necrotic cells monitored by Raman microspectroscopy. Sci Rep. 2014;4. doi:10.1038/ SREP04698
19. Malatesta P, Hartfuss E, Götz M. Isolation of radial glial cells by fl uorescent-activated cell sorting reveals a neuronal lineage. Development. 2000;127(24):5253-5263. doi:10.1242/ DEV.127.24.5253
20. Miyata T, Kawaguchi A, Okano H, Ogawa M. Asymmetric Inheritance of Radial Glial Fi- bers by Cortical Neurons. Neuron. 2001;31(5):727-741. doi:10.1016/S0896-6273(01)00420- 2
21. Hsieh J. Orchestrating transcriptional control of adult neurogenesis. Genes Dev. 2012;26(10):1010-1021. doi:10.1101/GAD.187336.112
22. Sierra A, Encinas JM, Deudero JJP, et al. Microglia Shape Adult Hippocampal Neurogenesis through Apoptosis-Coupled Phagocytosis. Cell Stem Cell. 2010;7(4):483-495. doi:10.1016/J. STEM.2010.08.014
23. Liu J, Li L, Suo WZ. HT22 hippocampal neuronal cell line possesses functional cholinergic properties. Life Sci. 2009;84(9-10):267-271. doi:10.1016/j.lfs.2008.12.008
24. He M, Liu J, Cheng S, Xing Y, Suo WZ. Diff erentiation renders susceptibility to excito- toxicity in HT22 neurons. Neural Regen Res. 2013;8(14):1297. doi:10.3969/J.ISSN.1673- 5374.2013.14.006
25. Lim J, Bang Y, Kim KM, Choi HJ. Diff erentiated HT22 cells as a novel model for in vitro screening of serotonin reuptake inhibitors. Front Pharmacol. 2023;13:5432. doi:10.3389/ FPHAR.2022.1062650/BIBTEX
26. Zhao Z, Lu R, Zhang B, et al. Diff erentiation of HT22 neurons induces expressi- on of NMDA receptor that mediates homocysteine cytotoxicity. http://dx.doi.or- g/101179/1743132811Y0000000057. 2013;34(1):38-43. doi:10.1179/174313281 1Y.0000000057

APA	Bilir F, Batman D, ÇORAKÇI A, yucesoy i (2023). Relationship between Hematological Inflammatory Markers and General Characteristics in Operable Cervical Cancer; State of the HALP index. , 384 - 389. 10.31832/smj.1319887
Chicago	Bilir Filiz,Batman Didem,ÇORAKÇI AYDIN,yucesoy izzet Relationship between Hematological Inflammatory Markers and General Characteristics in Operable Cervical Cancer; State of the HALP index. (2023): 384 - 389. 10.31832/smj.1319887
MLA	Bilir Filiz,Batman Didem,ÇORAKÇI AYDIN,yucesoy izzet Relationship between Hematological Inflammatory Markers and General Characteristics in Operable Cervical Cancer; State of the HALP index. , 2023, ss.384 - 389. 10.31832/smj.1319887
AMA	Bilir F,Batman D,ÇORAKÇI A,yucesoy i Relationship between Hematological Inflammatory Markers and General Characteristics in Operable Cervical Cancer; State of the HALP index. . 2023; 384 - 389. 10.31832/smj.1319887
Vancouver	Bilir F,Batman D,ÇORAKÇI A,yucesoy i Relationship between Hematological Inflammatory Markers and General Characteristics in Operable Cervical Cancer; State of the HALP index. . 2023; 384 - 389. 10.31832/smj.1319887
IEEE	Bilir F,Batman D,ÇORAKÇI A,yucesoy i "Relationship between Hematological Inflammatory Markers and General Characteristics in Operable Cervical Cancer; State of the HALP index." , ss.384 - 389, 2023. 10.31832/smj.1319887
ISNAD	Bilir, Filiz vd. "Relationship between Hematological Inflammatory Markers and General Characteristics in Operable Cervical Cancer; State of the HALP index". (2023), 384-389. https://doi.org/10.31832/smj.1319887

APA	Bilir F, Batman D, ÇORAKÇI A, yucesoy i (2023). Relationship between Hematological Inflammatory Markers and General Characteristics in Operable Cervical Cancer; State of the HALP index. Sakarya Tıp Dergisi, 13(3), 384 - 389. 10.31832/smj.1319887
Chicago	Bilir Filiz,Batman Didem,ÇORAKÇI AYDIN,yucesoy izzet Relationship between Hematological Inflammatory Markers and General Characteristics in Operable Cervical Cancer; State of the HALP index. Sakarya Tıp Dergisi 13, no.3 (2023): 384 - 389. 10.31832/smj.1319887
MLA	Bilir Filiz,Batman Didem,ÇORAKÇI AYDIN,yucesoy izzet Relationship between Hematological Inflammatory Markers and General Characteristics in Operable Cervical Cancer; State of the HALP index. Sakarya Tıp Dergisi, vol.13, no.3, 2023, ss.384 - 389. 10.31832/smj.1319887
AMA	Bilir F,Batman D,ÇORAKÇI A,yucesoy i Relationship between Hematological Inflammatory Markers and General Characteristics in Operable Cervical Cancer; State of the HALP index. Sakarya Tıp Dergisi. 2023; 13(3): 384 - 389. 10.31832/smj.1319887
Vancouver	Bilir F,Batman D,ÇORAKÇI A,yucesoy i Relationship between Hematological Inflammatory Markers and General Characteristics in Operable Cervical Cancer; State of the HALP index. Sakarya Tıp Dergisi. 2023; 13(3): 384 - 389. 10.31832/smj.1319887
IEEE	Bilir F,Batman D,ÇORAKÇI A,yucesoy i "Relationship between Hematological Inflammatory Markers and General Characteristics in Operable Cervical Cancer; State of the HALP index." Sakarya Tıp Dergisi, 13, ss.384 - 389, 2023. 10.31832/smj.1319887
ISNAD	Bilir, Filiz vd. "Relationship between Hematological Inflammatory Markers and General Characteristics in Operable Cervical Cancer; State of the HALP index". Sakarya Tıp Dergisi 13/3 (2023), 384-389. https://doi.org/10.31832/smj.1319887