Possible effects of N-acetylcysteine in autism spectrum disorders: major clinical aspects, eating behaviors, and sleeping habits

nalbant, kevser; ERDEN, SEMİH

doi:10.24953/turkjped.2022.573

Possible effects of N-acetylcysteine in autism spectrum disorders: major clinical aspects, eating behaviors, and sleeping habits

Kevser NALBANT, (Hacettepe Üniversitesi, Tıp Fakültesi, Çocuk ve Ergen Psikiyatrisi Anabilim Dalı, Ankara, Türkiye)

Semih ERDEN (Necmettin Erbakan Üniversitesi, Meram Tıp Fakültesi, Çocuk ve Çocuk Hastalıkları Anabilim Dalı, Ergen Psikiyatrisi, Konya, Türkiye)

Turkish Journal of Pediatrics

3 0

Yıl: 2023 Cilt: 65 Sayı: 5 Sayfa Aralığı: 832 - 844 Metin Dili: İngilizce DOI: 10.24953/turkjped.2022.573 İndeks Tarihi: 15-11-2023

Possible effects of N-acetylcysteine in autism spectrum disorders: major clinical aspects, eating behaviors, and sleeping habits

Öz:

Background. N-acetylcysteine (NAC) is a promising agent for reducing irritability and hyperactivity and enhancing social responsiveness in children with autism spectrum disorders (ASD). This study aims to examine the effects of NAC on cardinal symptoms, eating, and sleeping habits in preschool children with autism. Methods. The medical records of ASD patients were investigated retrospectively. 37 children with ASD who regularly received oral NAC in two divided doses per day (400-600 mg/day) for 8 weeks were included as the study group. The control group consisted of 21 children with ASD who were recommended NAC but never used it. The initial and second assessment scores after 8 weeks of regular use of the NAC group and control group on the Childhood Autism Rating Scale (CARS), Aberrant Behavior Checklist (ABC), Children Eating Behavior Questionnaire (CEBQ), and the Sleep Habits Questionnaire (CSHQ) were compared. Results. Our findings suggested that oral NAC alleviated the intensity of cardinal autistic symptoms in areas of social withdrawal, interpersonal relationships, body use, listening response, and verbal communication. Corresponding problem behaviors such as irritability, stereotypic behavior, and hyperactivity were reduced. It was determined that there was no difference between the two groups in terms of eating behaviors and sleeping habits. Conclusions. According to the results, NAC alleviated the severity of cardinal symptoms and reduced problem behaviors in autism. Additional trials with more systematic planning, controlling for confounding effects, and long-term follow-up should be provided in future studies.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	nalbant k, ERDEN S (2023). Possible effects of N-acetylcysteine in autism spectrum disorders: major clinical aspects, eating behaviors, and sleeping habits. , 832 - 844. 10.24953/turkjped.2022.573
Chicago	nalbant kevser,ERDEN SEMİH Possible effects of N-acetylcysteine in autism spectrum disorders: major clinical aspects, eating behaviors, and sleeping habits. (2023): 832 - 844. 10.24953/turkjped.2022.573
MLA	nalbant kevser,ERDEN SEMİH Possible effects of N-acetylcysteine in autism spectrum disorders: major clinical aspects, eating behaviors, and sleeping habits. , 2023, ss.832 - 844. 10.24953/turkjped.2022.573
AMA	nalbant k,ERDEN S Possible effects of N-acetylcysteine in autism spectrum disorders: major clinical aspects, eating behaviors, and sleeping habits. . 2023; 832 - 844. 10.24953/turkjped.2022.573
Vancouver	nalbant k,ERDEN S Possible effects of N-acetylcysteine in autism spectrum disorders: major clinical aspects, eating behaviors, and sleeping habits. . 2023; 832 - 844. 10.24953/turkjped.2022.573
IEEE	nalbant k,ERDEN S "Possible effects of N-acetylcysteine in autism spectrum disorders: major clinical aspects, eating behaviors, and sleeping habits." , ss.832 - 844, 2023. 10.24953/turkjped.2022.573
ISNAD	nalbant, kevser - ERDEN, SEMİH. "Possible effects of N-acetylcysteine in autism spectrum disorders: major clinical aspects, eating behaviors, and sleeping habits". (2023), 832-844. https://doi.org/10.24953/turkjped.2022.573

APA	nalbant k, ERDEN S (2023). Possible effects of N-acetylcysteine in autism spectrum disorders: major clinical aspects, eating behaviors, and sleeping habits. Turkish Journal of Pediatrics, 65(5), 832 - 844. 10.24953/turkjped.2022.573
Chicago	nalbant kevser,ERDEN SEMİH Possible effects of N-acetylcysteine in autism spectrum disorders: major clinical aspects, eating behaviors, and sleeping habits. Turkish Journal of Pediatrics 65, no.5 (2023): 832 - 844. 10.24953/turkjped.2022.573
MLA	nalbant kevser,ERDEN SEMİH Possible effects of N-acetylcysteine in autism spectrum disorders: major clinical aspects, eating behaviors, and sleeping habits. Turkish Journal of Pediatrics, vol.65, no.5, 2023, ss.832 - 844. 10.24953/turkjped.2022.573
AMA	nalbant k,ERDEN S Possible effects of N-acetylcysteine in autism spectrum disorders: major clinical aspects, eating behaviors, and sleeping habits. Turkish Journal of Pediatrics. 2023; 65(5): 832 - 844. 10.24953/turkjped.2022.573
Vancouver	nalbant k,ERDEN S Possible effects of N-acetylcysteine in autism spectrum disorders: major clinical aspects, eating behaviors, and sleeping habits. Turkish Journal of Pediatrics. 2023; 65(5): 832 - 844. 10.24953/turkjped.2022.573
IEEE	nalbant k,ERDEN S "Possible effects of N-acetylcysteine in autism spectrum disorders: major clinical aspects, eating behaviors, and sleeping habits." Turkish Journal of Pediatrics, 65, ss.832 - 844, 2023. 10.24953/turkjped.2022.573
ISNAD	nalbant, kevser - ERDEN, SEMİH. "Possible effects of N-acetylcysteine in autism spectrum disorders: major clinical aspects, eating behaviors, and sleeping habits". Turkish Journal of Pediatrics 65/5 (2023), 832-844. https://doi.org/10.24953/turkjped.2022.573