TY  - JOUR
TI  - Synthesis of alnustone-like diarylpentanoids via a 4 + 1 strategy and assessment of their potential anticancer activity
AB  - Twelve compounds with a 1,5-diaryl-1-penten-3-one structure were synthesized and their cytotoxic activities were evaluated. The 1,5-diaryl-1-penten-3-one compounds were obtained via in situ enaminations of 4-phenyl-2-butanone and 4-(4-hydroxyphenyl)-2- butanone in the presence of pyrrolidine-AcOH, followed by condensation with six different benzaldehydes. The synthesized compounds were tested for their cytotoxic activity against human glioblastoma (U87-MG), breast (MCF-7), and prostate (PC-3) cancer cell lines. Some of the novel compounds exhibited remarkable cytotoxic action, especially against MCF-7 cancer cells.
AU  - Çelebioğlu, Neslihan
AU  - Özdemir Tozlu, Özlem
AU  - Turkez, Hasan
AU  - Seçen, Hasan
DO  - 10.55730/1300-0527.3609
PY  - 2023
JO  - Turkish Journal of Chemistry
VL  - 47
IS  - 5
SN  - 1300-0527
SP  - 1249
EP  - 1259
DB  - TRDizin
UR  - http://search/yayin/detay/1208494
ER  -