Ameliorating effects of low-dose ketamine administrations on opioid-induced memory impairments and neurodegeneration in mice

Seker, Ugur; Ozhan, Onural; AÇIKGÜL, Muhammet Burak; İZCİ, Sevde Feyza; Uyar, Emre; ÇOLAK, Mehmet; Parlakpinar, Hakan

doi:10.5455/annalsmedres.2023.09.241

Ameliorating effects of low-dose ketamine administrations on opioid-induced memory impairments and neurodegeneration in mice

Emre UYAR, (İnönü Üniversitesi, Eczacılık Fakültesi, Farmakoloji Anabilim Dalı, Malatya, Türkiye)

Ugur SEKER, (Artuklu Üniversitesi, Tıp Fakültesi, Histoloji ve Embriyoloji Anabilim Dalı, Mardin, Türkiye)

Onural OZHAN, (İnönü Üniversitesi, Tıp Fakültesi, Farmakoloji Anabilim Dalı, Malatya, Türkiye)

Muhammet Burak ACIKGUL, (İnönü Üniversitesi, Eczacılık Fakültesi, Farmakoloji Anabilim Dalı, Malatya, Türkiye)

Mehmet COLAK, (İnönü Üniversitesi, Tıp Fakültesi, Farmakoloji Anabilim Dalı, Malatya, Türkiye)

Sevde Feyza IZCI, (İnönü Üniversitesi, Eczacılık Fakültesi, Farmakoloji Anabilim Dalı, Malatya, Türkiye)

Hakan PARLAKPINAR (İnönü Üniversitesi, Tıp Fakültesi, Farmakoloji Anabilim Dalı, Malatya, Türkiye)

Annals of Medical Research

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Yıl: 2023 Cilt: 30 Sayı: 11 Sayfa Aralığı: 1437 - 1441 Metin Dili: İngilizce DOI: 10.5455/annalsmedres.2023.09.241 İndeks Tarihi: 01-12-2023

Ameliorating effects of low-dose ketamine administrations on opioid-induced memory impairments and neurodegeneration in mice

Öz:

Aim: Opioids have indispensable roles in pain management. A strong link exists between opioid use and memory impairments, mainly with continuous use. This study investigated the effects of two opioid drugs, meperidine and fentanyl, on emotional memory functions, brain morphology, and the possible protective effects of low-dose ketamine in mice. Materials and Methods: A passive avoidance (PA) test was used to measure emotional memory functions following seven daily drug applications in 48 male Balb/C mice (30-35 g). Meperidine (10 mg/kg), fentanyl (0.3 mg/kg), ketamine (5 mg/kg), and combinations of ketamine with the opioids were intraperitoneally injected daily. No drugs were utilized during the testing days. Brain tissues were obtained after sacrification and put into diluted formalin solution for histopathological analysis. Results: Transfer latencies of the meperidine and fentanyl-treated groups in the PA test were lower than in the vehicle-treated group (p<0.01, p<0.05, respectively). Ketamine combined with meperidine had higher latencies than in the meperidine-treated group (p<0.05). The augmenting effects of ketamine were evident against fentanyl and meperidine-induced neurotoxicity as morphologic alterations were reduced. Conclusion: Low-dose ketamine may fend against opioid-induced neurotoxicity and emotional memory impairments, especially against meperidine, which can be a practical alternative to fentanyl in clinical settings.

Anahtar Kelime: Ketamine Opioids Memory impairments Passive avoidance Brain morphology

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Uyar E, Seker U, Ozhan O, AÇIKGÜL M, ÇOLAK M, İZCİ S, Parlakpinar H (2023). Ameliorating effects of low-dose ketamine administrations on opioid-induced memory impairments and neurodegeneration in mice. , 1437 - 1441. 10.5455/annalsmedres.2023.09.241
Chicago	Uyar Emre,Seker Ugur,Ozhan Onural,AÇIKGÜL Muhammet Burak,ÇOLAK Mehmet,İZCİ Sevde Feyza,Parlakpinar Hakan Ameliorating effects of low-dose ketamine administrations on opioid-induced memory impairments and neurodegeneration in mice. (2023): 1437 - 1441. 10.5455/annalsmedres.2023.09.241
MLA	Uyar Emre,Seker Ugur,Ozhan Onural,AÇIKGÜL Muhammet Burak,ÇOLAK Mehmet,İZCİ Sevde Feyza,Parlakpinar Hakan Ameliorating effects of low-dose ketamine administrations on opioid-induced memory impairments and neurodegeneration in mice. , 2023, ss.1437 - 1441. 10.5455/annalsmedres.2023.09.241
AMA	Uyar E,Seker U,Ozhan O,AÇIKGÜL M,ÇOLAK M,İZCİ S,Parlakpinar H Ameliorating effects of low-dose ketamine administrations on opioid-induced memory impairments and neurodegeneration in mice. . 2023; 1437 - 1441. 10.5455/annalsmedres.2023.09.241
Vancouver	Uyar E,Seker U,Ozhan O,AÇIKGÜL M,ÇOLAK M,İZCİ S,Parlakpinar H Ameliorating effects of low-dose ketamine administrations on opioid-induced memory impairments and neurodegeneration in mice. . 2023; 1437 - 1441. 10.5455/annalsmedres.2023.09.241
IEEE	Uyar E,Seker U,Ozhan O,AÇIKGÜL M,ÇOLAK M,İZCİ S,Parlakpinar H "Ameliorating effects of low-dose ketamine administrations on opioid-induced memory impairments and neurodegeneration in mice." , ss.1437 - 1441, 2023. 10.5455/annalsmedres.2023.09.241
ISNAD	Uyar, Emre vd. "Ameliorating effects of low-dose ketamine administrations on opioid-induced memory impairments and neurodegeneration in mice". (2023), 1437-1441. https://doi.org/10.5455/annalsmedres.2023.09.241

APA	Uyar E, Seker U, Ozhan O, AÇIKGÜL M, ÇOLAK M, İZCİ S, Parlakpinar H (2023). Ameliorating effects of low-dose ketamine administrations on opioid-induced memory impairments and neurodegeneration in mice. Annals of Medical Research, 30(11), 1437 - 1441. 10.5455/annalsmedres.2023.09.241
Chicago	Uyar Emre,Seker Ugur,Ozhan Onural,AÇIKGÜL Muhammet Burak,ÇOLAK Mehmet,İZCİ Sevde Feyza,Parlakpinar Hakan Ameliorating effects of low-dose ketamine administrations on opioid-induced memory impairments and neurodegeneration in mice. Annals of Medical Research 30, no.11 (2023): 1437 - 1441. 10.5455/annalsmedres.2023.09.241
MLA	Uyar Emre,Seker Ugur,Ozhan Onural,AÇIKGÜL Muhammet Burak,ÇOLAK Mehmet,İZCİ Sevde Feyza,Parlakpinar Hakan Ameliorating effects of low-dose ketamine administrations on opioid-induced memory impairments and neurodegeneration in mice. Annals of Medical Research, vol.30, no.11, 2023, ss.1437 - 1441. 10.5455/annalsmedres.2023.09.241
AMA	Uyar E,Seker U,Ozhan O,AÇIKGÜL M,ÇOLAK M,İZCİ S,Parlakpinar H Ameliorating effects of low-dose ketamine administrations on opioid-induced memory impairments and neurodegeneration in mice. Annals of Medical Research. 2023; 30(11): 1437 - 1441. 10.5455/annalsmedres.2023.09.241
Vancouver	Uyar E,Seker U,Ozhan O,AÇIKGÜL M,ÇOLAK M,İZCİ S,Parlakpinar H Ameliorating effects of low-dose ketamine administrations on opioid-induced memory impairments and neurodegeneration in mice. Annals of Medical Research. 2023; 30(11): 1437 - 1441. 10.5455/annalsmedres.2023.09.241
IEEE	Uyar E,Seker U,Ozhan O,AÇIKGÜL M,ÇOLAK M,İZCİ S,Parlakpinar H "Ameliorating effects of low-dose ketamine administrations on opioid-induced memory impairments and neurodegeneration in mice." Annals of Medical Research, 30, ss.1437 - 1441, 2023. 10.5455/annalsmedres.2023.09.241
ISNAD	Uyar, Emre vd. "Ameliorating effects of low-dose ketamine administrations on opioid-induced memory impairments and neurodegeneration in mice". Annals of Medical Research 30/11 (2023), 1437-1441. https://doi.org/10.5455/annalsmedres.2023.09.241